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The clinical features of alcohol use disorders in biological and step-fathers that predict risk for alcohol use disorders in offspring

Kendler, Kenneth S. LU ; Ohlsson, Henrik LU ; Edwards, Alexis LU ; Sundquist, Jan LU and Sundquist, Kristina LU (2017) In American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics 174(8). p.779-785
Abstract

Given that Alcohol Use Disorder (AUD) is clinically heterogeneous, can we, in a large epidemiological sample using public registries, identify clinical features of AUD cases in biological and step-fathers that index, respectively, genetic and familial-environmental risk for AUD in their offspring? From all father-offspring pairs where the father had AUD and the offspring was born 1960–1990, we identified not-lived-with (NLW) biological fathers (n = 38,376) and step-father pairs (n = 9,711). The relationship between clinical and historical features of the father's AUD and risk for AUD in offspring was assessed by linear hazard regression. Age at first registration for AUD and recurrence of AUD registration were significantly stronger... (More)

Given that Alcohol Use Disorder (AUD) is clinically heterogeneous, can we, in a large epidemiological sample using public registries, identify clinical features of AUD cases in biological and step-fathers that index, respectively, genetic and familial-environmental risk for AUD in their offspring? From all father-offspring pairs where the father had AUD and the offspring was born 1960–1990, we identified not-lived-with (NLW) biological fathers (n = 38,376) and step-father pairs (n = 9,711). The relationship between clinical and historical features of the father's AUD and risk for AUD in offspring was assessed by linear hazard regression. Age at first registration for AUD and recurrence of AUD registration were significantly stronger predictors of risk for AUD in the offspring of NLW fathers than in step-fathers. By contrast, number of AUD registrations in NLW fathers and step-fathers were equally predictive of risk for AUD in offspring. However, while the number of step-father AUD registrations that occurred when he was living them with significantly predicted risk for AUD in his step-children, the number of registrations that occurred when not residing with his step-children was unassociated with their AUD risk. In an epidemiological sample, we could meaningfully differentiate between features of AUD in fathers that indexed genetic risk which was transmitted to biological offspring (early age at onset and recurrence) versus indexed environmental risk (registrations while rearing) which increased risk in step-children.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
alcohol use disorder, genetic risk, number of registrations, rearing effects, step-fathers
in
American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
volume
174
issue
8
pages
7 pages
publisher
International Society of Psychiatric Genetics
external identifiers
  • scopus:85028547378
  • wos:000415128100003
ISSN
1552-4841
DOI
10.1002/ajmg.b.32583
language
English
LU publication?
yes
id
67c098c4-3f4e-4691-a3d6-5ca744ec2b5e
date added to LUP
2017-12-12 07:53:35
date last changed
2018-01-16 13:27:35
@article{67c098c4-3f4e-4691-a3d6-5ca744ec2b5e,
  abstract     = {<p>Given that Alcohol Use Disorder (AUD) is clinically heterogeneous, can we, in a large epidemiological sample using public registries, identify clinical features of AUD cases in biological and step-fathers that index, respectively, genetic and familial-environmental risk for AUD in their offspring? From all father-offspring pairs where the father had AUD and the offspring was born 1960–1990, we identified not-lived-with (NLW) biological fathers (n = 38,376) and step-father pairs (n = 9,711). The relationship between clinical and historical features of the father's AUD and risk for AUD in offspring was assessed by linear hazard regression. Age at first registration for AUD and recurrence of AUD registration were significantly stronger predictors of risk for AUD in the offspring of NLW fathers than in step-fathers. By contrast, number of AUD registrations in NLW fathers and step-fathers were equally predictive of risk for AUD in offspring. However, while the number of step-father AUD registrations that occurred when he was living them with significantly predicted risk for AUD in his step-children, the number of registrations that occurred when not residing with his step-children was unassociated with their AUD risk. In an epidemiological sample, we could meaningfully differentiate between features of AUD in fathers that indexed genetic risk which was transmitted to biological offspring (early age at onset and recurrence) versus indexed environmental risk (registrations while rearing) which increased risk in step-children.</p>},
  author       = {Kendler, Kenneth S. and Ohlsson, Henrik and Edwards, Alexis and Sundquist, Jan and Sundquist, Kristina},
  issn         = {1552-4841},
  keyword      = {alcohol use disorder,genetic risk,number of registrations,rearing effects,step-fathers},
  language     = {eng},
  month        = {12},
  number       = {8},
  pages        = {779--785},
  publisher    = {International Society of Psychiatric Genetics},
  series       = {American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics},
  title        = {The clinical features of alcohol use disorders in biological and step-fathers that predict risk for alcohol use disorders in offspring},
  url          = {http://dx.doi.org/10.1002/ajmg.b.32583},
  volume       = {174},
  year         = {2017},
}