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A whole genome scan for differences in recombination rates among three Bos taurus breeds

Thomsen, Hauke LU orcid ; Reinsch, Norbert ; Xu, Ningying ; Bennewitz, Jörn ; Looft, Christian ; Grupe, Sven ; Kühn, Christa ; Brockmann, Gudrun A. ; Schwerin, Manfred and Leyhe-Horn, Birgit , et al. (2001) In Mammalian Genome 12(9). p.724-728
Abstract

Twenty paternal half-sib families of a granddaughter design were genotyped for 265 genetic markers, most of them microsatellites. These were 16 Holstein families, 3 Simmental families, and 1 Brown Swiss family. The number of sires per breed was 872, 170, and 32, respectively. Two-point recombination rates were estimated both jointly for all breeds and each single breed separately. Of 1168 marker intervals, 865 provided estimates for at least two breeds. Differences between breeds were tested by likelihood ratio tests. Four marker intervals, representing three genomic regions on BTA19, BTA24, and BTA27, show a significant impact of the breed at a false discovery rate of 0.23 and indicate a genetic component of observed heterogeneity of... (More)

Twenty paternal half-sib families of a granddaughter design were genotyped for 265 genetic markers, most of them microsatellites. These were 16 Holstein families, 3 Simmental families, and 1 Brown Swiss family. The number of sires per breed was 872, 170, and 32, respectively. Two-point recombination rates were estimated both jointly for all breeds and each single breed separately. Of 1168 marker intervals, 865 provided estimates for at least two breeds. Differences between breeds were tested by likelihood ratio tests. Four marker intervals, representing three genomic regions on BTA19, BTA24, and BTA27, show a significant impact of the breed at a false discovery rate of 0.23 and indicate a genetic component of observed heterogeneity of recombination. The variability of recombination rates between cattle breeds might not be a common feature of the whole genome, but rather might be restricted to certain chromosomal segments. Thus, attention should be paid to heterogeneities when pooling data of such regions from different breeds.

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publishing date
type
Contribution to journal
publication status
published
in
Mammalian Genome
volume
12
issue
9
pages
5 pages
publisher
Springer
external identifiers
  • pmid:11641721
  • scopus:17944377506
ISSN
0938-8990
DOI
10.1007/s00335-001-2068-0
language
English
LU publication?
no
id
67d01a78-ed51-4d7c-9372-f72eb128deeb
date added to LUP
2018-10-10 13:44:26
date last changed
2025-01-08 16:59:17
@article{67d01a78-ed51-4d7c-9372-f72eb128deeb,
  abstract     = {{<p>Twenty paternal half-sib families of a granddaughter design were genotyped for 265 genetic markers, most of them microsatellites. These were 16 Holstein families, 3 Simmental families, and 1 Brown Swiss family. The number of sires per breed was 872, 170, and 32, respectively. Two-point recombination rates were estimated both jointly for all breeds and each single breed separately. Of 1168 marker intervals, 865 provided estimates for at least two breeds. Differences between breeds were tested by likelihood ratio tests. Four marker intervals, representing three genomic regions on BTA19, BTA24, and BTA27, show a significant impact of the breed at a false discovery rate of 0.23 and indicate a genetic component of observed heterogeneity of recombination. The variability of recombination rates between cattle breeds might not be a common feature of the whole genome, but rather might be restricted to certain chromosomal segments. Thus, attention should be paid to heterogeneities when pooling data of such regions from different breeds.</p>}},
  author       = {{Thomsen, Hauke and Reinsch, Norbert and Xu, Ningying and Bennewitz, Jörn and Looft, Christian and Grupe, Sven and Kühn, Christa and Brockmann, Gudrun A. and Schwerin, Manfred and Leyhe-Horn, Birgit and Hiendleder, Stefan and Erhardt, Georg and Medjugorac, Ivica and Russ, Ingolp and Förster, Martin and Brenig, Bertram and Reinhardt, Fritz and Reents, Reinhard and Blümel, Jürgen and Averdunk, Gottfried and Kalm, Ernst}},
  issn         = {{0938-8990}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{9}},
  pages        = {{724--728}},
  publisher    = {{Springer}},
  series       = {{Mammalian Genome}},
  title        = {{A whole genome scan for differences in recombination rates among three Bos taurus breeds}},
  url          = {{http://dx.doi.org/10.1007/s00335-001-2068-0}},
  doi          = {{10.1007/s00335-001-2068-0}},
  volume       = {{12}},
  year         = {{2001}},
}