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Cardiovascular Disease, Diabetes Mellitus, and Hypertension in Lewy Body Disease: A Comparison with Other Dementia Disorders

Javanshiri, Keivan LU orcid ; Haglund, Mattias LU and Englund, Elisabet LU orcid (2019) In Journal of Alzheimer's disease : JAD 71(3). p.851-859
Abstract
Background:
Research concerning the potential roles of cardiovascular disease (CaVD) and diabetes mellitus (DM) as risk factors for Lewy body disease (LBD) is limited. These disorders are, however, established risk factors for vascular dementia (VaD) and have been proposed as risk factors for Alzheimer’s disease (AD).
Objective:
The aim of this study was to investigate the prevalence of CaVD and DM in LBD and compare the results with previous findings in cases with AD, VaD, and mixed AD-VaD (MD).
Methods:
Autopsy reports at the Clinical Department of Pathology in Lund from 2001–2018 were analyzed. All cases with a complete neuropathological diagnosis of LBD were selected, not distinguishing between subjects with... (More)
Background:
Research concerning the potential roles of cardiovascular disease (CaVD) and diabetes mellitus (DM) as risk factors for Lewy body disease (LBD) is limited. These disorders are, however, established risk factors for vascular dementia (VaD) and have been proposed as risk factors for Alzheimer’s disease (AD).
Objective:
The aim of this study was to investigate the prevalence of CaVD and DM in LBD and compare the results with previous findings in cases with AD, VaD, and mixed AD-VaD (MD).
Methods:
Autopsy reports at the Clinical Department of Pathology in Lund from 2001–2018 were analyzed. All cases with a complete neuropathological diagnosis of LBD were selected, not distinguishing between subjects with clinical Parkinson disease dementia and dementia with Lewy bodies, on the condition of a clinical diagnosis of dementia. Clinical data were retrieved through the patients’ medical records and the Swedish National Diabetes Register (NDR) and compared with those of the AD, VaD, and MD cases.
Results:
In LBD, there was less CaVD, significantly less DM (p = 0.002) and likewise significantly less hypertension (p < 0.001) than in VaD. The results of the LBD group were consistent with the results of the AD group.
Conclusion
Our findings of a low prevalence of CaVD and CaVD risk factors in LBD and in AD argue against the association between these risk factors and their contribution to the development of neurodegenerative diseases. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Alzheimer’s disease, autopsy, cardiovascular disease, dementia, diabetes mellitus, hypertension, Lewy body disease, risk factors, vascular
in
Journal of Alzheimer's disease : JAD
volume
71
issue
3
pages
851 - 859
publisher
IOS Press
external identifiers
  • scopus:85073090623
  • pmid:31450500
ISSN
1387-2877
DOI
10.3233/JAD-190485
project
Cardiac and vascular pathology in Lewy body disease and Alzheimer's disease: exploring neurocognitive disorder beyond the brain
language
English
LU publication?
yes
id
67d430ab-51ea-4355-b0d6-455bfcd960b3
date added to LUP
2019-08-23 10:44:38
date last changed
2024-01-31 05:15:47
@article{67d430ab-51ea-4355-b0d6-455bfcd960b3,
  abstract     = {{Background:<br>
Research concerning the potential roles of cardiovascular disease (CaVD) and diabetes mellitus (DM) as risk factors for Lewy body disease (LBD) is limited. These disorders are, however, established risk factors for vascular dementia (VaD) and have been proposed as risk factors for Alzheimer’s disease (AD).<br>
Objective:<br>
The aim of this study was to investigate the prevalence of CaVD and DM in LBD and compare the results with previous findings in cases with AD, VaD, and mixed AD-VaD (MD).<br>
Methods:<br>
Autopsy reports at the Clinical Department of Pathology in Lund from 2001–2018 were analyzed. All cases with a complete neuropathological diagnosis of LBD were selected, not distinguishing between subjects with clinical Parkinson disease dementia and dementia with Lewy bodies, on the condition of a clinical diagnosis of dementia. Clinical data were retrieved through the patients’ medical records and the Swedish National Diabetes Register (NDR) and compared with those of the AD, VaD, and MD cases.<br>
Results:<br>
In LBD, there was less CaVD, significantly less DM (p = 0.002) and likewise significantly less hypertension (p &lt; 0.001) than in VaD. The results of the LBD group were consistent with the results of the AD group.<br>
Conclusion<br>
Our findings of a low prevalence of CaVD and CaVD risk factors in LBD and in AD argue against the association between these risk factors and their contribution to the development of neurodegenerative diseases.}},
  author       = {{Javanshiri, Keivan and Haglund, Mattias and Englund, Elisabet}},
  issn         = {{1387-2877}},
  keywords     = {{Alzheimer’s disease, autopsy, cardiovascular disease, dementia, diabetes mellitus, hypertension, Lewy body disease, risk factors, vascular}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{3}},
  pages        = {{851--859}},
  publisher    = {{IOS Press}},
  series       = {{Journal of Alzheimer's disease : JAD}},
  title        = {{Cardiovascular Disease, Diabetes Mellitus, and Hypertension in Lewy Body Disease: A Comparison with Other Dementia Disorders}},
  url          = {{http://dx.doi.org/10.3233/JAD-190485}},
  doi          = {{10.3233/JAD-190485}},
  volume       = {{71}},
  year         = {{2019}},
}