Update on non-typeable Haemophilus influenzae-mediated disease and vaccine development
Jalalvand, Farshid LU and Riesbeck, Kristian LU
(2018)
In Expert Review of Vaccines
17(6).
p.503-512
- Abstract
Introduction: Non-typeable Haemophilus influenzae (NTHi) has attracted more interest in recent years due to an increased prevalence of infections caused by the pathogen. This upsurge is at least partly ascribed to the introduction of the pneumococcal conjugated vaccines that has resulted in an aetiological shift in NTHi’s favor with respect to upper respiratory tract infections. Moreover, an increased antimicrobial resistance has been associated with the pathogen, a fact that further strengthens the case for novel vaccine development. Areas covered: A background to NTHi-mediated diseases and pathogenesis is outlined. The literature in the field of NTHi vaccine antigens and clinical trials is reviewed with focus on data added to... (More)
Introduction: Non-typeable Haemophilus influenzae (NTHi) has attracted more interest in recent years due to an increased prevalence of infections caused by the pathogen. This upsurge is at least partly ascribed to the introduction of the pneumococcal conjugated vaccines that has resulted in an aetiological shift in NTHi’s favor with respect to upper respiratory tract infections. Moreover, an increased antimicrobial resistance has been associated with the pathogen, a fact that further strengthens the case for novel vaccine development. Areas covered: A background to NTHi-mediated diseases and pathogenesis is outlined. The literature in the field of NTHi vaccine antigens and clinical trials is reviewed with focus on data added to scientific databases in the last two years. Various vaccine development strategies are conceptually discussed. Expert commentary: Several promising vaccine antigens have been defined in recent years. A multicomponent protein-based vaccine, potentially boosted with extracellular vesicles, would constitute a suitable path going forward. Of note, however, a clinical trial investigating the efficacy of a combined NTHi/Moraxella catarrhalis vaccine to prevent infections in chronic obstructive pulmonary disease (COPD) patients has been initiated. But, as this clinical trial has not yet concluded, and its results are thus unknown, investigations of NTHi pathogenesis must determinedly continue.
(Less)
- author
- Jalalvand, Farshid
LU
and Riesbeck, Kristian
LU
- organization
- publishing date
- 2018-06-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Acute otitis media, AOM, chronic obstructive pulmonary disease, COPD, Moraxella catarrhalis, non-typeable Haemophilus influenzae, protein-based vaccine, Streptococcus pneumoniae
- in
- Expert Review of Vaccines
- volume
- 17
- issue
- 6
- pages
- 10 pages
- publisher
- Future Drugs Ltd
- external identifiers
-
- pmid:29863956
- scopus:85049589788
- ISSN
- 1476-0584
- DOI
- 10.1080/14760584.2018.1484286
- language
- English
- LU publication?
- yes
- id
- 680a43bc-ad33-4377-bdb2-5a0a961b95e4
- date added to LUP
- 2018-07-25 10:53:46
- date last changed
- 2024-04-01 08:34:09
@article{680a43bc-ad33-4377-bdb2-5a0a961b95e4,
abstract = {{<p>Introduction: Non-typeable Haemophilus influenzae (NTHi) has attracted more interest in recent years due to an increased prevalence of infections caused by the pathogen. This upsurge is at least partly ascribed to the introduction of the pneumococcal conjugated vaccines that has resulted in an aetiological shift in NTHi’s favor with respect to upper respiratory tract infections. Moreover, an increased antimicrobial resistance has been associated with the pathogen, a fact that further strengthens the case for novel vaccine development. Areas covered: A background to NTHi-mediated diseases and pathogenesis is outlined. The literature in the field of NTHi vaccine antigens and clinical trials is reviewed with focus on data added to scientific databases in the last two years. Various vaccine development strategies are conceptually discussed. Expert commentary: Several promising vaccine antigens have been defined in recent years. A multicomponent protein-based vaccine, potentially boosted with extracellular vesicles, would constitute a suitable path going forward. Of note, however, a clinical trial investigating the efficacy of a combined NTHi/Moraxella catarrhalis vaccine to prevent infections in chronic obstructive pulmonary disease (COPD) patients has been initiated. But, as this clinical trial has not yet concluded, and its results are thus unknown, investigations of NTHi pathogenesis must determinedly continue.</p>}},
author = {{Jalalvand, Farshid and Riesbeck, Kristian}},
issn = {{1476-0584}},
keywords = {{Acute otitis media; AOM; chronic obstructive pulmonary disease; COPD; Moraxella catarrhalis; non-typeable Haemophilus influenzae; protein-based vaccine; Streptococcus pneumoniae}},
language = {{eng}},
month = {{06}},
number = {{6}},
pages = {{503--512}},
publisher = {{Future Drugs Ltd}},
series = {{Expert Review of Vaccines}},
title = {{Update on non-typeable Haemophilus influenzae-mediated disease and vaccine development}},
url = {{http://dx.doi.org/10.1080/14760584.2018.1484286}},
doi = {{10.1080/14760584.2018.1484286}},
volume = {{17}},
year = {{2018}},
}