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Feeding strategies for E-coli fermentations demanding an enriched environment

de Maré, Lena LU ; Cimander, C.; Elfwing, A. and Hagander, Per LU (2007) In Bioprocess and Biosystems Engineering 30(1). p.13-25
Abstract
The addition of a carbon nutrient feed to a fed-batch cultivation is often not enough to obtain satisfactory growth and/or production. In some cases, an additional feed with for example supplementary amino acids or complex media is required. This work presents the development of feeding strategies where more than one feed is required and the knowledge of the growth requirements is low. Simulations and cultivations with E. coli are shown using the proposed feed controllers which are based on a probing control concept. The strategies work well and they can be used to shorten the process development phase considerably.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Escherichia coli, complex medium, amino acid, fed-batch cultivation, fermentation process, feeding strategy
in
Bioprocess and Biosystems Engineering
volume
30
issue
1
pages
13 - 25
publisher
Springer
external identifiers
  • wos:000243031400002
  • scopus:33845898187
ISSN
1615-7605
DOI
10.1007/s00449-006-0090-z
language
English
LU publication?
yes
id
cb2f83f6-dbb6-40dc-9748-da05ec7833a8 (old id 681968)
date added to LUP
2007-12-06 15:47:40
date last changed
2017-02-12 04:05:25
@article{cb2f83f6-dbb6-40dc-9748-da05ec7833a8,
  abstract     = {The addition of a carbon nutrient feed to a fed-batch cultivation is often not enough to obtain satisfactory growth and/or production. In some cases, an additional feed with for example supplementary amino acids or complex media is required. This work presents the development of feeding strategies where more than one feed is required and the knowledge of the growth requirements is low. Simulations and cultivations with E. coli are shown using the proposed feed controllers which are based on a probing control concept. The strategies work well and they can be used to shorten the process development phase considerably.},
  author       = {de Maré, Lena and Cimander, C. and Elfwing, A. and Hagander, Per},
  issn         = {1615-7605},
  keyword      = {Escherichia coli,complex medium,amino acid,fed-batch cultivation,fermentation process,feeding strategy},
  language     = {eng},
  number       = {1},
  pages        = {13--25},
  publisher    = {Springer},
  series       = {Bioprocess and Biosystems Engineering},
  title        = {Feeding strategies for E-coli fermentations demanding an enriched environment},
  url          = {http://dx.doi.org/10.1007/s00449-006-0090-z},
  volume       = {30},
  year         = {2007},
}