Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Deficient Fas expression by CD4+CCR5+T cells in multiple sclerosis

Julia, Eva ; Montalban, Xavier ; Al-zayat, Hanimad ; Issazadeh, Shohreh LU ; Goertsches, Robert ; Martin, Roland and Comabella, Manuel (2006) In Journal of Neuroimmunology 180(1-2). p.147-158
Abstract
Objective: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. Methods: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. Results: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. Interpretation: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
multiple sclerosis, T cells, apoptosis
in
Journal of Neuroimmunology
volume
180
issue
1-2
pages
147 - 158
publisher
Elsevier
external identifiers
  • wos:000242694500016
  • scopus:33750618350
ISSN
1872-8421
DOI
10.1016/j.jneuroim.2006.07.001
language
English
LU publication?
yes
id
3ca6914e-4148-439a-a83d-17e17acc6a5d (old id 682454)
date added to LUP
2016-04-01 11:52:18
date last changed
2022-01-26 19:31:33
@article{3ca6914e-4148-439a-a83d-17e17acc6a5d,
  abstract     = {{Objective: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. Methods: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. Results: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. Interpretation: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.}},
  author       = {{Julia, Eva and Montalban, Xavier and Al-zayat, Hanimad and Issazadeh, Shohreh and Goertsches, Robert and Martin, Roland and Comabella, Manuel}},
  issn         = {{1872-8421}},
  keywords     = {{multiple sclerosis; T cells; apoptosis}},
  language     = {{eng}},
  number       = {{1-2}},
  pages        = {{147--158}},
  publisher    = {{Elsevier}},
  series       = {{Journal of Neuroimmunology}},
  title        = {{Deficient Fas expression by CD4+CCR5+T cells in multiple sclerosis}},
  url          = {{http://dx.doi.org/10.1016/j.jneuroim.2006.07.001}},
  doi          = {{10.1016/j.jneuroim.2006.07.001}},
  volume       = {{180}},
  year         = {{2006}},
}