Deficient Fas expression by CD4+CCR5+T cells in multiple sclerosis
(2006) In Journal of Neuroimmunology 180(1-2). p.147-158- Abstract
- Objective: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. Methods: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. Results: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. Interpretation: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/682454
- author
- Julia, Eva ; Montalban, Xavier ; Al-zayat, Hanimad ; Issazadeh, Shohreh LU ; Goertsches, Robert ; Martin, Roland and Comabella, Manuel
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- multiple sclerosis, T cells, apoptosis
- in
- Journal of Neuroimmunology
- volume
- 180
- issue
- 1-2
- pages
- 147 - 158
- publisher
- Elsevier
- external identifiers
-
- wos:000242694500016
- scopus:33750618350
- ISSN
- 1872-8421
- DOI
- 10.1016/j.jneuroim.2006.07.001
- language
- English
- LU publication?
- yes
- id
- 3ca6914e-4148-439a-a83d-17e17acc6a5d (old id 682454)
- date added to LUP
- 2016-04-01 11:52:18
- date last changed
- 2022-01-26 19:31:33
@article{3ca6914e-4148-439a-a83d-17e17acc6a5d, abstract = {{Objective: To evaluate whether T cells expressing CCR5 and CXCR3 from multiple sclerosis (MS) patients are more resistant to apoptosis. Methods: Expression of CD69, TNF-R1, Fas, FasL, bcl-2, and bax was investigated in 41 MS patients and 12 healthy controls by flow cytometry in CD4+ and CD8+ T cells expressing CCR5 and CXCR3. Results: In MS patients, the percentage of CD69 was increased and Fas expression decreased in CD4+ CCR5+ T cells. Interpretation: The lower Fas expression in activated CD4+ CCR5+ T cells might contribute to disease pathogenesis by prolonging cell survival and favoring their migration into the CNS.}}, author = {{Julia, Eva and Montalban, Xavier and Al-zayat, Hanimad and Issazadeh, Shohreh and Goertsches, Robert and Martin, Roland and Comabella, Manuel}}, issn = {{1872-8421}}, keywords = {{multiple sclerosis; T cells; apoptosis}}, language = {{eng}}, number = {{1-2}}, pages = {{147--158}}, publisher = {{Elsevier}}, series = {{Journal of Neuroimmunology}}, title = {{Deficient Fas expression by CD4+CCR5+T cells in multiple sclerosis}}, url = {{http://dx.doi.org/10.1016/j.jneuroim.2006.07.001}}, doi = {{10.1016/j.jneuroim.2006.07.001}}, volume = {{180}}, year = {{2006}}, }