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Proenkephalin-A mRNA is widely expressed in tissues of the human gastrointestinal tract

Monstein, Hans-Jurg ; Grahn, Niclas and Ohlsson, Bodil LU (2006) In European Surgical Research 38(5). p.464-468
Abstract
Background: It has been shown that the non-opioid effects of Met-enkephalin, which is derived from proenkephalin-A, are mediated through a specific opioid growth factor (OGF) receptor which is assumed to be involved in the control of cell growth. The expression and tissue location of proenkephalin-A mRNA in the gastrointestinal tract remains largely unknown. Methods: In this study we have analyzed the expression of proenkephalin-A mRNA in the human esophagus, gastrointestinal tract and surrounding organs by means of reverse-transcriptase PCR (RT-PCR). Results: The present study demonstrates proenkephalin-A mRNA expression in the human esophagus, gastrointestinal tract, pancreas, and gallbladder. Conclusion: The present study demonstrates... (More)
Background: It has been shown that the non-opioid effects of Met-enkephalin, which is derived from proenkephalin-A, are mediated through a specific opioid growth factor (OGF) receptor which is assumed to be involved in the control of cell growth. The expression and tissue location of proenkephalin-A mRNA in the gastrointestinal tract remains largely unknown. Methods: In this study we have analyzed the expression of proenkephalin-A mRNA in the human esophagus, gastrointestinal tract and surrounding organs by means of reverse-transcriptase PCR (RT-PCR). Results: The present study demonstrates proenkephalin-A mRNA expression in the human esophagus, gastrointestinal tract, pancreas, and gallbladder. Conclusion: The present study demonstrates proenkephalin-A mRNA expression in regions of the human esophagus, gastrointestinal tract, pancreas, and gallbladder tissues which provides information for the future mapping of proenkephalin-A mRNA and protein expression/co-expression at the cellular level. Copyright (c) 2006 S. Karger AG, Basel. (Less)
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author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
control of, cell growth, proenkephalin-A mRNA, opioid growth factor, gastrointestinal tract
in
European Surgical Research
volume
38
issue
5
pages
464 - 468
publisher
Karger
external identifiers
  • wos:000241617000006
  • scopus:33750201473
ISSN
0014-312X
DOI
10.1159/000095414
language
English
LU publication?
yes
id
bed33b99-f583-4340-afb3-bd3fb3f407f5 (old id 685861)
date added to LUP
2016-04-01 11:34:46
date last changed
2022-01-26 07:15:06
@article{bed33b99-f583-4340-afb3-bd3fb3f407f5,
  abstract     = {{Background: It has been shown that the non-opioid effects of Met-enkephalin, which is derived from proenkephalin-A, are mediated through a specific opioid growth factor (OGF) receptor which is assumed to be involved in the control of cell growth. The expression and tissue location of proenkephalin-A mRNA in the gastrointestinal tract remains largely unknown. Methods: In this study we have analyzed the expression of proenkephalin-A mRNA in the human esophagus, gastrointestinal tract and surrounding organs by means of reverse-transcriptase PCR (RT-PCR). Results: The present study demonstrates proenkephalin-A mRNA expression in the human esophagus, gastrointestinal tract, pancreas, and gallbladder. Conclusion: The present study demonstrates proenkephalin-A mRNA expression in regions of the human esophagus, gastrointestinal tract, pancreas, and gallbladder tissues which provides information for the future mapping of proenkephalin-A mRNA and protein expression/co-expression at the cellular level. Copyright (c) 2006 S. Karger AG, Basel.}},
  author       = {{Monstein, Hans-Jurg and Grahn, Niclas and Ohlsson, Bodil}},
  issn         = {{0014-312X}},
  keywords     = {{control of; cell growth; proenkephalin-A mRNA; opioid growth factor; gastrointestinal tract}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{464--468}},
  publisher    = {{Karger}},
  series       = {{European Surgical Research}},
  title        = {{Proenkephalin-A mRNA is widely expressed in tissues of the human gastrointestinal tract}},
  url          = {{http://dx.doi.org/10.1159/000095414}},
  doi          = {{10.1159/000095414}},
  volume       = {{38}},
  year         = {{2006}},
}