Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Proenkephalin-A mRNA is widely expressed in tissues of the human gastrointestinal tract

Monstein, Hans-Jurg ; Grahn, Niclas and Ohlsson, Bodil LU (2006) In European Surgical Research 38(5). p.464-468
Abstract
Background: It has been shown that the non-opioid effects of Met-enkephalin, which is derived from proenkephalin-A, are mediated through a specific opioid growth factor (OGF) receptor which is assumed to be involved in the control of cell growth. The expression and tissue location of proenkephalin-A mRNA in the gastrointestinal tract remains largely unknown. Methods: In this study we have analyzed the expression of proenkephalin-A mRNA in the human esophagus, gastrointestinal tract and surrounding organs by means of reverse-transcriptase PCR (RT-PCR). Results: The present study demonstrates proenkephalin-A mRNA expression in the human esophagus, gastrointestinal tract, pancreas, and gallbladder. Conclusion: The present study demonstrates... (More)
Background: It has been shown that the non-opioid effects of Met-enkephalin, which is derived from proenkephalin-A, are mediated through a specific opioid growth factor (OGF) receptor which is assumed to be involved in the control of cell growth. The expression and tissue location of proenkephalin-A mRNA in the gastrointestinal tract remains largely unknown. Methods: In this study we have analyzed the expression of proenkephalin-A mRNA in the human esophagus, gastrointestinal tract and surrounding organs by means of reverse-transcriptase PCR (RT-PCR). Results: The present study demonstrates proenkephalin-A mRNA expression in the human esophagus, gastrointestinal tract, pancreas, and gallbladder. Conclusion: The present study demonstrates proenkephalin-A mRNA expression in regions of the human esophagus, gastrointestinal tract, pancreas, and gallbladder tissues which provides information for the future mapping of proenkephalin-A mRNA and protein expression/co-expression at the cellular level. Copyright (c) 2006 S. Karger AG, Basel. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
control of, cell growth, proenkephalin-A mRNA, opioid growth factor, gastrointestinal tract
in
European Surgical Research
volume
38
issue
5
pages
464 - 468
publisher
Karger
external identifiers
  • wos:000241617000006
  • scopus:33750201473
ISSN
0014-312X
DOI
10.1159/000095414
language
English
LU publication?
yes
id
bed33b99-f583-4340-afb3-bd3fb3f407f5 (old id 685861)
date added to LUP
2016-04-01 11:34:46
date last changed
2021-09-22 04:39:18
@article{bed33b99-f583-4340-afb3-bd3fb3f407f5,
  abstract     = {Background: It has been shown that the non-opioid effects of Met-enkephalin, which is derived from proenkephalin-A, are mediated through a specific opioid growth factor (OGF) receptor which is assumed to be involved in the control of cell growth. The expression and tissue location of proenkephalin-A mRNA in the gastrointestinal tract remains largely unknown. Methods: In this study we have analyzed the expression of proenkephalin-A mRNA in the human esophagus, gastrointestinal tract and surrounding organs by means of reverse-transcriptase PCR (RT-PCR). Results: The present study demonstrates proenkephalin-A mRNA expression in the human esophagus, gastrointestinal tract, pancreas, and gallbladder. Conclusion: The present study demonstrates proenkephalin-A mRNA expression in regions of the human esophagus, gastrointestinal tract, pancreas, and gallbladder tissues which provides information for the future mapping of proenkephalin-A mRNA and protein expression/co-expression at the cellular level. Copyright (c) 2006 S. Karger AG, Basel.},
  author       = {Monstein, Hans-Jurg and Grahn, Niclas and Ohlsson, Bodil},
  issn         = {0014-312X},
  language     = {eng},
  number       = {5},
  pages        = {464--468},
  publisher    = {Karger},
  series       = {European Surgical Research},
  title        = {Proenkephalin-A mRNA is widely expressed in tissues of the human gastrointestinal tract},
  url          = {http://dx.doi.org/10.1159/000095414},
  doi          = {10.1159/000095414},
  volume       = {38},
  year         = {2006},
}