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The relationships between the plasma metabolome and orthostatic blood pressure responses

Zambach, Christian LU orcid ; Pan, Jingxue LU ; Gerward, Sofia LU ; Fedorowski, Artur LU orcid ; Smith, J Gustav LU ; Engström, Gunnar LU and Hamrefors, Viktor LU orcid (2023) In Scientific Reports 13(1).
Abstract

Whereas autonomic dysfunction and the metabolic syndrome are clinically associated, the relationships with the plasma metabolome is unknown. We explored the association between orthostatic blood pressure responses and 818 plasma metabolites in middle-aged subjects from the general population. We included 3803 out of 6251 subjects (mean age, 57 years; 52% women) from the Malmö sub-cohort of The Swedish CardioPulmonary bioImage Study with information on smoking habits, diabetes, antihypertensive drug treatment, anthropometrics, hemodynamic measurements and 818 plasma metabolites (mass-spectrometry). The associations between each metabolite and orthostatic systolic blood pressure responses were determined using multivariable linear... (More)

Whereas autonomic dysfunction and the metabolic syndrome are clinically associated, the relationships with the plasma metabolome is unknown. We explored the association between orthostatic blood pressure responses and 818 plasma metabolites in middle-aged subjects from the general population. We included 3803 out of 6251 subjects (mean age, 57 years; 52% women) from the Malmö sub-cohort of The Swedish CardioPulmonary bioImage Study with information on smoking habits, diabetes, antihypertensive drug treatment, anthropometrics, hemodynamic measurements and 818 plasma metabolites (mass-spectrometry). The associations between each metabolite and orthostatic systolic blood pressure responses were determined using multivariable linear regression analysis and p values were corrected using the Bonferroni method. Six amino acids, five vitamins, co-factors and carbohydrates, nine lipids and two xenobiotics were associated with orthostatic blood pressure after adjusting for age, gender and systolic blood pressure. After additional adjustments for BMI, diabetes, smoking and antihypertensive treatment, the association remained significant for six lipids, four amino acids and one xenobiotic. Twenty-two out of 818 plasma metabolites were associated with orthostatic blood pressure responses. Eleven metabolites, including lipids in the dihydrosphingomyelin and sphingosine pathways, were independently associated with orthostatic systolic blood pressure responses after additional adjustment for markers of cardio-metabolic disease.

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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Middle Aged, Humans, Female, Male, Blood Pressure/physiology, Hypotension, Orthostatic, Antihypertensive Agents/pharmacology, Diabetes Mellitus, Metabolome, Amino Acids/pharmacology, Lipids/pharmacology
in
Scientific Reports
volume
13
issue
1
article number
18244
pages
10 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85174707491
  • pmid:37880314
ISSN
2045-2322
DOI
10.1038/s41598-023-44226-z
language
English
LU publication?
yes
additional info
© 2023. Springer Nature Limited.
id
685d29a8-83ce-4528-b0aa-0116e0fefc51
date added to LUP
2023-10-30 08:28:39
date last changed
2024-04-19 02:59:09
@article{685d29a8-83ce-4528-b0aa-0116e0fefc51,
  abstract     = {{<p>Whereas autonomic dysfunction and the metabolic syndrome are clinically associated, the relationships with the plasma metabolome is unknown. We explored the association between orthostatic blood pressure responses and 818 plasma metabolites in middle-aged subjects from the general population. We included 3803 out of 6251 subjects (mean age, 57 years; 52% women) from the Malmö sub-cohort of The Swedish CardioPulmonary bioImage Study with information on smoking habits, diabetes, antihypertensive drug treatment, anthropometrics, hemodynamic measurements and 818 plasma metabolites (mass-spectrometry). The associations between each metabolite and orthostatic systolic blood pressure responses were determined using multivariable linear regression analysis and p values were corrected using the Bonferroni method. Six amino acids, five vitamins, co-factors and carbohydrates, nine lipids and two xenobiotics were associated with orthostatic blood pressure after adjusting for age, gender and systolic blood pressure. After additional adjustments for BMI, diabetes, smoking and antihypertensive treatment, the association remained significant for six lipids, four amino acids and one xenobiotic. Twenty-two out of 818 plasma metabolites were associated with orthostatic blood pressure responses. Eleven metabolites, including lipids in the dihydrosphingomyelin and sphingosine pathways, were independently associated with orthostatic systolic blood pressure responses after additional adjustment for markers of cardio-metabolic disease.</p>}},
  author       = {{Zambach, Christian and Pan, Jingxue and Gerward, Sofia and Fedorowski, Artur and Smith, J Gustav and Engström, Gunnar and Hamrefors, Viktor}},
  issn         = {{2045-2322}},
  keywords     = {{Middle Aged; Humans; Female; Male; Blood Pressure/physiology; Hypotension, Orthostatic; Antihypertensive Agents/pharmacology; Diabetes Mellitus; Metabolome; Amino Acids/pharmacology; Lipids/pharmacology}},
  language     = {{eng}},
  month        = {{10}},
  number       = {{1}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{The relationships between the plasma metabolome and orthostatic blood pressure responses}},
  url          = {{http://dx.doi.org/10.1038/s41598-023-44226-z}},
  doi          = {{10.1038/s41598-023-44226-z}},
  volume       = {{13}},
  year         = {{2023}},
}