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Biphenotypic bigenotypic lymphoma with simultaneous expression of PAX5/BSAP and B- and T-cell markers

Hansson, Markus LU ; Jerkeman, Mats LU and Dictor, Michael LU (2007) In European Journal of Haematology 79(2). p.159-165
Abstract
Lymphomas are currently categorized according to their origin from a B or T lymphocyte. Immature and less commonly mature (peripheral) lymphomas may harbor rearrangements of both the B- and T-cell antigen receptor genes (dual genotype or bigenotype). Rarely, cells in lymphoma with a single genotype simultaneously express both B- and T-cell markers (biphenotypic lymphomas). We discuss the diagnostic and clinical implications in the case of a 42-yr-old female with a peripheral CD30(+) lymphoma that displayed both characteristic B- and T-cell surface antigens and clonal rearrangement of B- and T-cell antigen receptor gene loci. Simultaneous nuclear expression of the transcription factor gene PAX5 suggested that this major driver of B-cell... (More)
Lymphomas are currently categorized according to their origin from a B or T lymphocyte. Immature and less commonly mature (peripheral) lymphomas may harbor rearrangements of both the B- and T-cell antigen receptor genes (dual genotype or bigenotype). Rarely, cells in lymphoma with a single genotype simultaneously express both B- and T-cell markers (biphenotypic lymphomas). We discuss the diagnostic and clinical implications in the case of a 42-yr-old female with a peripheral CD30(+) lymphoma that displayed both characteristic B- and T-cell surface antigens and clonal rearrangement of B- and T-cell antigen receptor gene loci. Simultaneous nuclear expression of the transcription factor gene PAX5 suggested that this major driver of B-cell differentiation did not preclude expression of CD3 epsilon, generally assumed to be a T-cell associated antigen. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
PAX5, biphenotypic, lymphoma, bigenotypic
in
European Journal of Haematology
volume
79
issue
2
pages
159 - 165
publisher
Wiley-Blackwell
external identifiers
  • wos:000248450800011
  • scopus:34447514182
ISSN
1600-0609
DOI
10.1111/j.1600-0609.2007.00882.x
language
English
LU publication?
yes
id
c1df6f6a-65ad-4b99-9b3c-6b34f9b68619 (old id 686664)
date added to LUP
2007-12-07 15:39:25
date last changed
2017-01-01 04:25:12
@article{c1df6f6a-65ad-4b99-9b3c-6b34f9b68619,
  abstract     = {Lymphomas are currently categorized according to their origin from a B or T lymphocyte. Immature and less commonly mature (peripheral) lymphomas may harbor rearrangements of both the B- and T-cell antigen receptor genes (dual genotype or bigenotype). Rarely, cells in lymphoma with a single genotype simultaneously express both B- and T-cell markers (biphenotypic lymphomas). We discuss the diagnostic and clinical implications in the case of a 42-yr-old female with a peripheral CD30(+) lymphoma that displayed both characteristic B- and T-cell surface antigens and clonal rearrangement of B- and T-cell antigen receptor gene loci. Simultaneous nuclear expression of the transcription factor gene PAX5 suggested that this major driver of B-cell differentiation did not preclude expression of CD3 epsilon, generally assumed to be a T-cell associated antigen.},
  author       = {Hansson, Markus and Jerkeman, Mats and Dictor, Michael},
  issn         = {1600-0609},
  keyword      = {PAX5,biphenotypic,lymphoma,bigenotypic},
  language     = {eng},
  number       = {2},
  pages        = {159--165},
  publisher    = {Wiley-Blackwell},
  series       = {European Journal of Haematology},
  title        = {Biphenotypic bigenotypic lymphoma with simultaneous expression of PAX5/BSAP and B- and T-cell markers},
  url          = {http://dx.doi.org/10.1111/j.1600-0609.2007.00882.x},
  volume       = {79},
  year         = {2007},
}