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Synovial fluid expression of autoantibodies specific for RAGE relates to less erosive course of rheumatoid arthritis

Pullerits, R.; Bokarewa, M.; Dahlberg, Leif LU and Tarkowski, A. (2007) In Rheumatology 46(8). p.1367-1371
Abstract
Objectives. The receptor for advanced glycation end products (RAGE) is expressed by many cells in joints of rheumatoid arthritis (RA) patients and interacts with a variety of pro-inflammatory ligands that are enriched in inflamed joint. The RAGE-ligand interaction leads to a sustained inflammatory response. Also, secreted form of the receptor, called soluble RAGE (sRAGE), the levels of which are decreased in RA patients, modulates inflammatory responses. We sought to determine whether RA patients display increased occurrence of autoantibodies against RAGE and whether such an autoantibody production is related to disease characteristics. Methods. Matching samples of blood and synovial fluid were collected from 50 patients with RA with acute... (More)
Objectives. The receptor for advanced glycation end products (RAGE) is expressed by many cells in joints of rheumatoid arthritis (RA) patients and interacts with a variety of pro-inflammatory ligands that are enriched in inflamed joint. The RAGE-ligand interaction leads to a sustained inflammatory response. Also, secreted form of the receptor, called soluble RAGE (sRAGE), the levels of which are decreased in RA patients, modulates inflammatory responses. We sought to determine whether RA patients display increased occurrence of autoantibodies against RAGE and whether such an autoantibody production is related to disease characteristics. Methods. Matching samples of blood and synovial fluid were collected from 50 patients with RA with acute joint effusion. Blood from 43 healthy individuals and synovial fluid samples from 32 patients with non-inflammatory joint diseases were used for comparison. Anti-RAGE antibody levels were analysed using an ELISA. Results. RA patients displayed significantly higher blood and synovial fluid levels of anti-RAGE antibodies, both of IgG as well as of IgM class as compared with healthy controls and with patients with non-inflammatory joint diseases. Patients with seropositive RA had significantly less IgG antibodies in their synovial fluid as compared to seronegative patients. Furthermore, the presence of IgG class of anti-RAGE antibodies locally in the joint was found to be related to less aggressive, i.e. non-erosive disease. Conclusion. These results suggest that RAGE-specific B cell response protect patients with RA from destructive course of the disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
autoantibodies, rheumatoid arthritis, RAGE, HMGB1
in
Rheumatology
volume
46
issue
8
pages
1367 - 1371
publisher
Oxford University Press
external identifiers
  • wos:000248686800028
  • scopus:34547839815
ISSN
1462-0332
DOI
10.1093/rheumatology/kem141
language
English
LU publication?
yes
id
4b3d8fc7-da52-4ce3-b734-0d0535e0e5ae (old id 688653)
date added to LUP
2007-12-14 09:39:11
date last changed
2017-01-01 07:23:45
@article{4b3d8fc7-da52-4ce3-b734-0d0535e0e5ae,
  abstract     = {Objectives. The receptor for advanced glycation end products (RAGE) is expressed by many cells in joints of rheumatoid arthritis (RA) patients and interacts with a variety of pro-inflammatory ligands that are enriched in inflamed joint. The RAGE-ligand interaction leads to a sustained inflammatory response. Also, secreted form of the receptor, called soluble RAGE (sRAGE), the levels of which are decreased in RA patients, modulates inflammatory responses. We sought to determine whether RA patients display increased occurrence of autoantibodies against RAGE and whether such an autoantibody production is related to disease characteristics. Methods. Matching samples of blood and synovial fluid were collected from 50 patients with RA with acute joint effusion. Blood from 43 healthy individuals and synovial fluid samples from 32 patients with non-inflammatory joint diseases were used for comparison. Anti-RAGE antibody levels were analysed using an ELISA. Results. RA patients displayed significantly higher blood and synovial fluid levels of anti-RAGE antibodies, both of IgG as well as of IgM class as compared with healthy controls and with patients with non-inflammatory joint diseases. Patients with seropositive RA had significantly less IgG antibodies in their synovial fluid as compared to seronegative patients. Furthermore, the presence of IgG class of anti-RAGE antibodies locally in the joint was found to be related to less aggressive, i.e. non-erosive disease. Conclusion. These results suggest that RAGE-specific B cell response protect patients with RA from destructive course of the disease.},
  author       = {Pullerits, R. and Bokarewa, M. and Dahlberg, Leif and Tarkowski, A.},
  issn         = {1462-0332},
  keyword      = {autoantibodies,rheumatoid arthritis,RAGE,HMGB1},
  language     = {eng},
  number       = {8},
  pages        = {1367--1371},
  publisher    = {Oxford University Press},
  series       = {Rheumatology},
  title        = {Synovial fluid expression of autoantibodies specific for RAGE relates to less erosive course of rheumatoid arthritis},
  url          = {http://dx.doi.org/10.1093/rheumatology/kem141},
  volume       = {46},
  year         = {2007},
}