Synovial fluid expression of autoantibodies specific for RAGE relates to less erosive course of rheumatoid arthritis
(2007) In Rheumatology 46(8). p.1367-1371- Abstract
- Objectives. The receptor for advanced glycation end products (RAGE) is expressed by many cells in joints of rheumatoid arthritis (RA) patients and interacts with a variety of pro-inflammatory ligands that are enriched in inflamed joint. The RAGE-ligand interaction leads to a sustained inflammatory response. Also, secreted form of the receptor, called soluble RAGE (sRAGE), the levels of which are decreased in RA patients, modulates inflammatory responses. We sought to determine whether RA patients display increased occurrence of autoantibodies against RAGE and whether such an autoantibody production is related to disease characteristics. Methods. Matching samples of blood and synovial fluid were collected from 50 patients with RA with acute... (More)
- Objectives. The receptor for advanced glycation end products (RAGE) is expressed by many cells in joints of rheumatoid arthritis (RA) patients and interacts with a variety of pro-inflammatory ligands that are enriched in inflamed joint. The RAGE-ligand interaction leads to a sustained inflammatory response. Also, secreted form of the receptor, called soluble RAGE (sRAGE), the levels of which are decreased in RA patients, modulates inflammatory responses. We sought to determine whether RA patients display increased occurrence of autoantibodies against RAGE and whether such an autoantibody production is related to disease characteristics. Methods. Matching samples of blood and synovial fluid were collected from 50 patients with RA with acute joint effusion. Blood from 43 healthy individuals and synovial fluid samples from 32 patients with non-inflammatory joint diseases were used for comparison. Anti-RAGE antibody levels were analysed using an ELISA. Results. RA patients displayed significantly higher blood and synovial fluid levels of anti-RAGE antibodies, both of IgG as well as of IgM class as compared with healthy controls and with patients with non-inflammatory joint diseases. Patients with seropositive RA had significantly less IgG antibodies in their synovial fluid as compared to seronegative patients. Furthermore, the presence of IgG class of anti-RAGE antibodies locally in the joint was found to be related to less aggressive, i.e. non-erosive disease. Conclusion. These results suggest that RAGE-specific B cell response protect patients with RA from destructive course of the disease. (Less)
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https://lup.lub.lu.se/record/688653
- author
- Pullerits, R. ; Bokarewa, M. ; Dahlberg, Leif LU and Tarkowski, A.
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- autoantibodies, rheumatoid arthritis, RAGE, HMGB1
- in
- Rheumatology
- volume
- 46
- issue
- 8
- pages
- 1367 - 1371
- publisher
- Oxford University Press
- external identifiers
-
- wos:000248686800028
- scopus:34547839815
- ISSN
- 1462-0332
- DOI
- 10.1093/rheumatology/kem141
- language
- English
- LU publication?
- yes
- id
- 4b3d8fc7-da52-4ce3-b734-0d0535e0e5ae (old id 688653)
- date added to LUP
- 2016-04-01 17:05:05
- date last changed
- 2022-01-29 00:12:04
@article{4b3d8fc7-da52-4ce3-b734-0d0535e0e5ae,
abstract = {{Objectives. The receptor for advanced glycation end products (RAGE) is expressed by many cells in joints of rheumatoid arthritis (RA) patients and interacts with a variety of pro-inflammatory ligands that are enriched in inflamed joint. The RAGE-ligand interaction leads to a sustained inflammatory response. Also, secreted form of the receptor, called soluble RAGE (sRAGE), the levels of which are decreased in RA patients, modulates inflammatory responses. We sought to determine whether RA patients display increased occurrence of autoantibodies against RAGE and whether such an autoantibody production is related to disease characteristics. Methods. Matching samples of blood and synovial fluid were collected from 50 patients with RA with acute joint effusion. Blood from 43 healthy individuals and synovial fluid samples from 32 patients with non-inflammatory joint diseases were used for comparison. Anti-RAGE antibody levels were analysed using an ELISA. Results. RA patients displayed significantly higher blood and synovial fluid levels of anti-RAGE antibodies, both of IgG as well as of IgM class as compared with healthy controls and with patients with non-inflammatory joint diseases. Patients with seropositive RA had significantly less IgG antibodies in their synovial fluid as compared to seronegative patients. Furthermore, the presence of IgG class of anti-RAGE antibodies locally in the joint was found to be related to less aggressive, i.e. non-erosive disease. Conclusion. These results suggest that RAGE-specific B cell response protect patients with RA from destructive course of the disease.}},
author = {{Pullerits, R. and Bokarewa, M. and Dahlberg, Leif and Tarkowski, A.}},
issn = {{1462-0332}},
keywords = {{autoantibodies; rheumatoid arthritis; RAGE; HMGB1}},
language = {{eng}},
number = {{8}},
pages = {{1367--1371}},
publisher = {{Oxford University Press}},
series = {{Rheumatology}},
title = {{Synovial fluid expression of autoantibodies specific for RAGE relates to less erosive course of rheumatoid arthritis}},
url = {{http://dx.doi.org/10.1093/rheumatology/kem141}},
doi = {{10.1093/rheumatology/kem141}},
volume = {{46}},
year = {{2007}},
}