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Anti-trypanosomal alkaloids from Xymalos monospora

Ngarnga, Dieudonne ; Tane, Pierre ; Rattendi, Donna ; Bacchi, Cyrus ; Okunji, Christopher C. ; Iwu, Maurice M. ; Schuster, Brian M. and Sterner, Olov LU (2006) In Natural Product Communications 1(8). p.619-622
Abstract
From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid (1), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N-methyllaurotetanine) were isolated. These compounds were tested for growth inhibitory activity against bloodstream forms of three strains of African trypanosomes. In vitro IC50 values starting from 1.8 mu g/mL were obtained.
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
trypanosomiasis, antitrypanosomal, alkaloids, Xymalos monospora, monimiaceae, sleeping sickness
in
Natural Product Communications
volume
1
issue
8
pages
619 - 622
publisher
Natural Products Inc
external identifiers
  • wos:000249006500004
  • scopus:84900446334
ISSN
1934-578X
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
f9c4228b-e4ed-4e8b-8729-d867db18fa17 (old id 688874)
date added to LUP
2016-04-01 12:05:59
date last changed
2020-03-11 02:45:40
@article{f9c4228b-e4ed-4e8b-8729-d867db18fa17,
  abstract     = {From an extract of the stem bark of Xymalos monospora, a bis-benzylisoquinoline alkaloid (1), three benzylisoquinoline alkaloids (mollinedine, 1-(p-methoxybenzyl)-6,7-methylenedioxyisoquino-line, doryafranine), and an aporphine alkaloid (N-methyllaurotetanine) were isolated. These compounds were tested for growth inhibitory activity against bloodstream forms of three strains of African trypanosomes. In vitro IC50 values starting from 1.8 mu g/mL were obtained.},
  author       = {Ngarnga, Dieudonne and Tane, Pierre and Rattendi, Donna and Bacchi, Cyrus and Okunji, Christopher C. and Iwu, Maurice M. and Schuster, Brian M. and Sterner, Olov},
  issn         = {1934-578X},
  language     = {eng},
  number       = {8},
  pages        = {619--622},
  publisher    = {Natural Products Inc},
  series       = {Natural Product Communications},
  title        = {Anti-trypanosomal alkaloids from Xymalos monospora},
  volume       = {1},
  year         = {2006},
}