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M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes

Påhlman, Lisa LU ; Malmström, Erik LU ; Mörgelin, Matthias LU and Herwald, Heiko LU (2007) In Microbiology 153. p.2458-2464
Abstract
Invasive infections caused by the important pathogen Streptococcus pyogenes are often associated with disturbed blood coagulation in the human host, and may in severe cases develop into the life-threatening condition disseminated intravascular coagulation. In this study, the addition of M1 protein to human blood or purified peripheral blood mononuclear cells led to a dose-dependent increase of pro-coagulant activity, which was mediated by an upregulation of tissue factor on monocytes. Analysis of the resulting clots by transmission electron microscopy revealed that the cells were covered with a fibrin network that seemed to originate from the cell surface. Taken together, the results imply an important role for M proteins in the induction... (More)
Invasive infections caused by the important pathogen Streptococcus pyogenes are often associated with disturbed blood coagulation in the human host, and may in severe cases develop into the life-threatening condition disseminated intravascular coagulation. In this study, the addition of M1 protein to human blood or purified peripheral blood mononuclear cells led to a dose-dependent increase of pro-coagulant activity, which was mediated by an upregulation of tissue factor on monocytes. Analysis of the resulting clots by transmission electron microscopy revealed that the cells were covered with a fibrin network that seemed to originate from the cell surface. Taken together, the results imply an important role for M proteins in the induction of haemostatic disorders in invasive streptococcal infectious diseases. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Microbiology
volume
153
pages
2458 - 2464
publisher
MAIK Nauka/Interperiodica
external identifiers
  • wos:000249044900009
  • scopus:34547888407
ISSN
1465-2080
DOI
10.1099/mic.0.2006/003285-0
language
English
LU publication?
yes
id
b0dd7255-f3d9-40f7-bffa-c8deb3b2efc2 (old id 688894)
date added to LUP
2007-12-17 09:38:32
date last changed
2017-01-01 04:43:03
@article{b0dd7255-f3d9-40f7-bffa-c8deb3b2efc2,
  abstract     = {Invasive infections caused by the important pathogen Streptococcus pyogenes are often associated with disturbed blood coagulation in the human host, and may in severe cases develop into the life-threatening condition disseminated intravascular coagulation. In this study, the addition of M1 protein to human blood or purified peripheral blood mononuclear cells led to a dose-dependent increase of pro-coagulant activity, which was mediated by an upregulation of tissue factor on monocytes. Analysis of the resulting clots by transmission electron microscopy revealed that the cells were covered with a fibrin network that seemed to originate from the cell surface. Taken together, the results imply an important role for M proteins in the induction of haemostatic disorders in invasive streptococcal infectious diseases.},
  author       = {Påhlman, Lisa and Malmström, Erik and Mörgelin, Matthias and Herwald, Heiko},
  issn         = {1465-2080},
  language     = {eng},
  pages        = {2458--2464},
  publisher    = {MAIK Nauka/Interperiodica},
  series       = {Microbiology},
  title        = {M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes},
  url          = {http://dx.doi.org/10.1099/mic.0.2006/003285-0},
  volume       = {153},
  year         = {2007},
}