M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes
Påhlman, Lisa LU ; Malmström, Erik LU ; Mörgelin, Matthias LU and Herwald, Heiko LU
(2007)
In Microbiology
153.
p.2458-2464
- Abstract
- Invasive infections caused by the important pathogen Streptococcus pyogenes are often associated with disturbed blood coagulation in the human host, and may in severe cases develop into the life-threatening condition disseminated intravascular coagulation. In this study, the addition of M1 protein to human blood or purified peripheral blood mononuclear cells led to a dose-dependent increase of pro-coagulant activity, which was mediated by an upregulation of tissue factor on monocytes. Analysis of the resulting clots by transmission electron microscopy revealed that the cells were covered with a fibrin network that seemed to originate from the cell surface. Taken together, the results imply an important role for M proteins in the induction... (More)
- Invasive infections caused by the important pathogen Streptococcus pyogenes are often associated with disturbed blood coagulation in the human host, and may in severe cases develop into the life-threatening condition disseminated intravascular coagulation. In this study, the addition of M1 protein to human blood or purified peripheral blood mononuclear cells led to a dose-dependent increase of pro-coagulant activity, which was mediated by an upregulation of tissue factor on monocytes. Analysis of the resulting clots by transmission electron microscopy revealed that the cells were covered with a fibrin network that seemed to originate from the cell surface. Taken together, the results imply an important role for M proteins in the induction of haemostatic disorders in invasive streptococcal infectious diseases. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/688894
- author
- Påhlman, Lisa
LU
; Malmström, Erik
LU
; Mörgelin, Matthias
LU
and Herwald, Heiko
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Microbiology
- volume
- 153
- pages
- 2458 - 2464
- publisher
- MAIK Nauka/Interperiodica
- external identifiers
-
- wos:000249044900009
- scopus:34547888407
- ISSN
- 1465-2080
- DOI
- 10.1099/mic.0.2006/003285-0
- language
- English
- LU publication?
- yes
- id
- b0dd7255-f3d9-40f7-bffa-c8deb3b2efc2 (old id 688894)
- date added to LUP
- 2016-04-01 11:58:25
- date last changed
- 2022-03-28 18:23:06
@article{b0dd7255-f3d9-40f7-bffa-c8deb3b2efc2,
abstract = {{Invasive infections caused by the important pathogen Streptococcus pyogenes are often associated with disturbed blood coagulation in the human host, and may in severe cases develop into the life-threatening condition disseminated intravascular coagulation. In this study, the addition of M1 protein to human blood or purified peripheral blood mononuclear cells led to a dose-dependent increase of pro-coagulant activity, which was mediated by an upregulation of tissue factor on monocytes. Analysis of the resulting clots by transmission electron microscopy revealed that the cells were covered with a fibrin network that seemed to originate from the cell surface. Taken together, the results imply an important role for M proteins in the induction of haemostatic disorders in invasive streptococcal infectious diseases.}},
author = {{Påhlman, Lisa and Malmström, Erik and Mörgelin, Matthias and Herwald, Heiko}},
issn = {{1465-2080}},
language = {{eng}},
pages = {{2458--2464}},
publisher = {{MAIK Nauka/Interperiodica}},
series = {{Microbiology}},
title = {{M protein from Streptococcus pyogenes induces tissue factor expression and pro-coagulant activity in human monocytes}},
url = {{http://dx.doi.org/10.1099/mic.0.2006/003285-0}},
doi = {{10.1099/mic.0.2006/003285-0}},
volume = {{153}},
year = {{2007}},
}