Renal angioplasty causes a rapid transient increase in inflammatory biornarkers, but reduced levels of interleukin-6 and endothelin-1 1 month after intervention
(2007) In Journal of Hypertension 25(9). p.1907-1914- Abstract
- Objective To examine prospectively whether inflammatory biomarkers and endothelin (ET)-1 are increased in patients with renal artery stenosis (RAS), and to investigate how treatment with percutaneous transluminal renal angioplasty (PTRA) affects these variables during the first month after intervention. Methods One hundred patients with suspected RAS undergoing renal angiography were included. PTRA was performed if the trans-stenotic mean arterial pressure gradient was >= 10 mmHg. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF alpha), neopterin, CD40 ligand (CD40L) and endothelin-1 (ET-1) were measured before, and 1 day and 1 month after PTRA (n = 61) or diagnostic angiography only... (More)
- Objective To examine prospectively whether inflammatory biomarkers and endothelin (ET)-1 are increased in patients with renal artery stenosis (RAS), and to investigate how treatment with percutaneous transluminal renal angioplasty (PTRA) affects these variables during the first month after intervention. Methods One hundred patients with suspected RAS undergoing renal angiography were included. PTRA was performed if the trans-stenotic mean arterial pressure gradient was >= 10 mmHg. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF alpha), neopterin, CD40 ligand (CD40L) and endothelin-1 (ET-1) were measured before, and 1 day and 1 month after PTRA (n = 61) or diagnostic angiography only (n = 39). Results At baseline there were no significant differences in inflammatory biomarkers or ET-1 levels between patients subsequently undergoing PTRA or angiography only. After angiography, IL-6 and hs-CRP had increased in both groups compared to baseline (P< 0.001). At this time point hs-CRP (10.90 +/- 1.48 versus 6.37 +/- 1.61 mg/l; P<0.05) and IL-6 (13.70 +/- 0.94 versus 13.00 +/- 0.17 pg/ml; P<0.01) were higher in the PTRA group than in patients subjected to angiography only. One month after PTRA, systolic blood pressure and levels of IL-6 and ET-1 were lower than before intervention (P<0.05), whereas CD40L had increased compared to baseline (P<0.01). Conclusion In patients with RAS, PTRA triggers rapid transient increases in hs-CRP and IL-6; however, 1 month after PTRA, both IL-6 and ET-1 had decreased compared to before intervention, indicating beneficial effects of PTRA on inflammation and the endothelin system. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/688924
- author
- Alhadad, Alaa LU ; Guronb, Gregor ; Fortuna-Nowakowska, Ella ; Saeedb, Aso ; Mattiasson, Ingrid LU ; Jensen, Gert ; Lindblad, Bengt LU ; Gottsäter, Anders LU and Herlitz, Hans
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- renovascular hypertension, renal artery stenosis, tumor necrosis, factor-alpha, percutaneous transluminal renal angioplasty, neopterin, interleukin-6, inflammation, endothelin-1, cD40 ligand, C-reactive protein
- in
- Journal of Hypertension
- volume
- 25
- issue
- 9
- pages
- 1907 - 1914
- publisher
- Lippincott Williams & Wilkins
- external identifiers
-
- wos:000249054300022
- ISSN
- 1473-5598
- language
- English
- LU publication?
- yes
- id
- 059c35fc-0002-4ad6-9f99-fa527917dd45 (old id 688924)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17762656&dopt=Abstract
- date added to LUP
- 2016-04-01 16:53:02
- date last changed
- 2018-11-21 20:44:57
@article{059c35fc-0002-4ad6-9f99-fa527917dd45, abstract = {{Objective To examine prospectively whether inflammatory biomarkers and endothelin (ET)-1 are increased in patients with renal artery stenosis (RAS), and to investigate how treatment with percutaneous transluminal renal angioplasty (PTRA) affects these variables during the first month after intervention. Methods One hundred patients with suspected RAS undergoing renal angiography were included. PTRA was performed if the trans-stenotic mean arterial pressure gradient was >= 10 mmHg. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF alpha), neopterin, CD40 ligand (CD40L) and endothelin-1 (ET-1) were measured before, and 1 day and 1 month after PTRA (n = 61) or diagnostic angiography only (n = 39). Results At baseline there were no significant differences in inflammatory biomarkers or ET-1 levels between patients subsequently undergoing PTRA or angiography only. After angiography, IL-6 and hs-CRP had increased in both groups compared to baseline (P< 0.001). At this time point hs-CRP (10.90 +/- 1.48 versus 6.37 +/- 1.61 mg/l; P<0.05) and IL-6 (13.70 +/- 0.94 versus 13.00 +/- 0.17 pg/ml; P<0.01) were higher in the PTRA group than in patients subjected to angiography only. One month after PTRA, systolic blood pressure and levels of IL-6 and ET-1 were lower than before intervention (P<0.05), whereas CD40L had increased compared to baseline (P<0.01). Conclusion In patients with RAS, PTRA triggers rapid transient increases in hs-CRP and IL-6; however, 1 month after PTRA, both IL-6 and ET-1 had decreased compared to before intervention, indicating beneficial effects of PTRA on inflammation and the endothelin system.}}, author = {{Alhadad, Alaa and Guronb, Gregor and Fortuna-Nowakowska, Ella and Saeedb, Aso and Mattiasson, Ingrid and Jensen, Gert and Lindblad, Bengt and Gottsäter, Anders and Herlitz, Hans}}, issn = {{1473-5598}}, keywords = {{renovascular hypertension; renal artery stenosis; tumor necrosis; factor-alpha; percutaneous transluminal renal angioplasty; neopterin; interleukin-6; inflammation; endothelin-1; cD40 ligand; C-reactive protein}}, language = {{eng}}, number = {{9}}, pages = {{1907--1914}}, publisher = {{Lippincott Williams & Wilkins}}, series = {{Journal of Hypertension}}, title = {{Renal angioplasty causes a rapid transient increase in inflammatory biornarkers, but reduced levels of interleukin-6 and endothelin-1 1 month after intervention}}, url = {{http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17762656&dopt=Abstract}}, volume = {{25}}, year = {{2007}}, }