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Renal angioplasty causes a rapid transient increase in inflammatory biornarkers, but reduced levels of interleukin-6 and endothelin-1 1 month after intervention

Alhadad, Alaa LU ; Guronb, Gregor; Fortuna-Nowakowska, Ella; Saeedb, Aso; Mattiasson, Ingrid LU ; Jensen, Gert; Lindblad, Bengt LU ; Gottsäter, Anders LU and Herlitz, Hans (2007) In Journal of Hypertension 25(9). p.1907-1914
Abstract
Objective To examine prospectively whether inflammatory biomarkers and endothelin (ET)-1 are increased in patients with renal artery stenosis (RAS), and to investigate how treatment with percutaneous transluminal renal angioplasty (PTRA) affects these variables during the first month after intervention. Methods One hundred patients with suspected RAS undergoing renal angiography were included. PTRA was performed if the trans-stenotic mean arterial pressure gradient was >= 10 mmHg. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF alpha), neopterin, CD40 ligand (CD40L) and endothelin-1 (ET-1) were measured before, and 1 day and 1 month after PTRA (n = 61) or diagnostic angiography only... (More)
Objective To examine prospectively whether inflammatory biomarkers and endothelin (ET)-1 are increased in patients with renal artery stenosis (RAS), and to investigate how treatment with percutaneous transluminal renal angioplasty (PTRA) affects these variables during the first month after intervention. Methods One hundred patients with suspected RAS undergoing renal angiography were included. PTRA was performed if the trans-stenotic mean arterial pressure gradient was >= 10 mmHg. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF alpha), neopterin, CD40 ligand (CD40L) and endothelin-1 (ET-1) were measured before, and 1 day and 1 month after PTRA (n = 61) or diagnostic angiography only (n = 39). Results At baseline there were no significant differences in inflammatory biomarkers or ET-1 levels between patients subsequently undergoing PTRA or angiography only. After angiography, IL-6 and hs-CRP had increased in both groups compared to baseline (P< 0.001). At this time point hs-CRP (10.90 +/- 1.48 versus 6.37 +/- 1.61 mg/l; P<0.05) and IL-6 (13.70 +/- 0.94 versus 13.00 +/- 0.17 pg/ml; P<0.01) were higher in the PTRA group than in patients subjected to angiography only. One month after PTRA, systolic blood pressure and levels of IL-6 and ET-1 were lower than before intervention (P<0.05), whereas CD40L had increased compared to baseline (P<0.01). Conclusion In patients with RAS, PTRA triggers rapid transient increases in hs-CRP and IL-6; however, 1 month after PTRA, both IL-6 and ET-1 had decreased compared to before intervention, indicating beneficial effects of PTRA on inflammation and the endothelin system. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
renovascular hypertension, renal artery stenosis, tumor necrosis, factor-alpha, percutaneous transluminal renal angioplasty, neopterin, interleukin-6, inflammation, endothelin-1, cD40 ligand, C-reactive protein
in
Journal of Hypertension
volume
25
issue
9
pages
1907 - 1914
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000249054300022
ISSN
1473-5598
language
English
LU publication?
yes
id
059c35fc-0002-4ad6-9f99-fa527917dd45 (old id 688924)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17762656&dopt=Abstract
date added to LUP
2007-12-04 17:57:45
date last changed
2016-04-16 05:01:40
@article{059c35fc-0002-4ad6-9f99-fa527917dd45,
  abstract     = {Objective To examine prospectively whether inflammatory biomarkers and endothelin (ET)-1 are increased in patients with renal artery stenosis (RAS), and to investigate how treatment with percutaneous transluminal renal angioplasty (PTRA) affects these variables during the first month after intervention. Methods One hundred patients with suspected RAS undergoing renal angiography were included. PTRA was performed if the trans-stenotic mean arterial pressure gradient was &gt;= 10 mmHg. High-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF alpha), neopterin, CD40 ligand (CD40L) and endothelin-1 (ET-1) were measured before, and 1 day and 1 month after PTRA (n = 61) or diagnostic angiography only (n = 39). Results At baseline there were no significant differences in inflammatory biomarkers or ET-1 levels between patients subsequently undergoing PTRA or angiography only. After angiography, IL-6 and hs-CRP had increased in both groups compared to baseline (P&lt; 0.001). At this time point hs-CRP (10.90 +/- 1.48 versus 6.37 +/- 1.61 mg/l; P&lt;0.05) and IL-6 (13.70 +/- 0.94 versus 13.00 +/- 0.17 pg/ml; P&lt;0.01) were higher in the PTRA group than in patients subjected to angiography only. One month after PTRA, systolic blood pressure and levels of IL-6 and ET-1 were lower than before intervention (P&lt;0.05), whereas CD40L had increased compared to baseline (P&lt;0.01). Conclusion In patients with RAS, PTRA triggers rapid transient increases in hs-CRP and IL-6; however, 1 month after PTRA, both IL-6 and ET-1 had decreased compared to before intervention, indicating beneficial effects of PTRA on inflammation and the endothelin system.},
  author       = {Alhadad, Alaa and Guronb, Gregor and Fortuna-Nowakowska, Ella and Saeedb, Aso and Mattiasson, Ingrid and Jensen, Gert and Lindblad, Bengt and Gottsäter, Anders and Herlitz, Hans},
  issn         = {1473-5598},
  keyword      = {renovascular hypertension,renal artery stenosis,tumor necrosis,factor-alpha,percutaneous transluminal renal angioplasty,neopterin,interleukin-6,inflammation,endothelin-1,cD40 ligand,C-reactive protein},
  language     = {eng},
  number       = {9},
  pages        = {1907--1914},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Journal of Hypertension},
  title        = {Renal angioplasty causes a rapid transient increase in inflammatory biornarkers, but reduced levels of interleukin-6 and endothelin-1 1 month after intervention},
  volume       = {25},
  year         = {2007},
}