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Intraductal papillary mucinous neoplasms of the pancreas – a cost-effectiveness analysis of management strategies for the branch-duct subtype

Aronsson, Linus LU ; Ansari, Daniel LU ; Andersson, Bodil LU orcid ; Persson, Ulf LU ; Fridhammar, Adam and Andersson, Roland LU (2018) In HPB 20(12). p.1206-1214
Abstract

Background: Branch-duct intraductal papillary mucinous neoplasm (BD-IPMN) presents a clinical conundrum. Rigorous long-term surveillance or surgical resection is recommended. The economic consequences of the management have not been fully investigated. Methods: A Markov decision model compared 4 strategies for low-risk BD-IPMN: I = upfront total pancreatectomy, II = upfront partial pancreatectomy, III = initial surveillance, IV = watchful waiting. Surveillance was based on the Swedish Guidelines for Pancreatic Cancer. Probabilities and costs were obtained from the participating unit and from the scientific literature. The incremental cost-effectiveness ratios (ICERs) were calculated and sensitivity analyses were performed by varying... (More)

Background: Branch-duct intraductal papillary mucinous neoplasm (BD-IPMN) presents a clinical conundrum. Rigorous long-term surveillance or surgical resection is recommended. The economic consequences of the management have not been fully investigated. Methods: A Markov decision model compared 4 strategies for low-risk BD-IPMN: I = upfront total pancreatectomy, II = upfront partial pancreatectomy, III = initial surveillance, IV = watchful waiting. Surveillance was based on the Swedish Guidelines for Pancreatic Cancer. Probabilities and costs were obtained from the participating unit and from the scientific literature. The incremental cost-effectiveness ratios (ICERs) were calculated and sensitivity analyses were performed by varying relevant parameters. Survival was reported in quality-adjusted life-years (QALYs). Results: Strategy III was the most cost-effective strategy with an ICER of €31 682 compared to strategy IV. Strategy I was the most expensive but yielded the best QALY (9.32). Total number of years, annual risk of pancreatic cancer and annual risk of a low-risk BD-IPMN turning into a high-risk lesion had the greatest impact in the model. Conclusions: Initial surveillance seems to be the most cost-effective strategy in the management of low-risk asymptomatic BD-IPMN. However, the possibility of personalized approaches remains to be investigated.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
HPB
volume
20
issue
12
pages
1206 - 1214
publisher
Elsevier
external identifiers
  • pmid:30064727
  • scopus:85050620776
ISSN
1365-182X
DOI
10.1016/j.hpb.2018.06.1801
language
English
LU publication?
yes
id
68914f99-a0e3-4c98-b86b-8b4aa16158b8
date added to LUP
2018-09-24 14:46:34
date last changed
2025-10-16 02:09:25
@article{68914f99-a0e3-4c98-b86b-8b4aa16158b8,
  abstract     = {{<p>Background: Branch-duct intraductal papillary mucinous neoplasm (BD-IPMN) presents a clinical conundrum. Rigorous long-term surveillance or surgical resection is recommended. The economic consequences of the management have not been fully investigated. Methods: A Markov decision model compared 4 strategies for low-risk BD-IPMN: I = upfront total pancreatectomy, II = upfront partial pancreatectomy, III = initial surveillance, IV = watchful waiting. Surveillance was based on the Swedish Guidelines for Pancreatic Cancer. Probabilities and costs were obtained from the participating unit and from the scientific literature. The incremental cost-effectiveness ratios (ICERs) were calculated and sensitivity analyses were performed by varying relevant parameters. Survival was reported in quality-adjusted life-years (QALYs). Results: Strategy III was the most cost-effective strategy with an ICER of €31 682 compared to strategy IV. Strategy I was the most expensive but yielded the best QALY (9.32). Total number of years, annual risk of pancreatic cancer and annual risk of a low-risk BD-IPMN turning into a high-risk lesion had the greatest impact in the model. Conclusions: Initial surveillance seems to be the most cost-effective strategy in the management of low-risk asymptomatic BD-IPMN. However, the possibility of personalized approaches remains to be investigated.</p>}},
  author       = {{Aronsson, Linus and Ansari, Daniel and Andersson, Bodil and Persson, Ulf and Fridhammar, Adam and Andersson, Roland}},
  issn         = {{1365-182X}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{1206--1214}},
  publisher    = {{Elsevier}},
  series       = {{HPB}},
  title        = {{Intraductal papillary mucinous neoplasms of the pancreas – a cost-effectiveness analysis of management strategies for the branch-duct subtype}},
  url          = {{http://dx.doi.org/10.1016/j.hpb.2018.06.1801}},
  doi          = {{10.1016/j.hpb.2018.06.1801}},
  volume       = {{20}},
  year         = {{2018}},
}