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Remarkably long survival of a patient with Ph1-positive chronic myeloid leukemia and 5' bcr rearrangement

Johansson, Bertil LU ; Mertens, Fredrik LU ; Fioretos, Thoas LU ; Heim, Sverre LU ; Kristoffersson, Ulf LU ; Mandahl, Nils LU ; Bartram, C R and Mitelman, Felix LU orcid (1990) In Leukemia 4(6). p.448-449
Abstract
Chronic myeloid leukemia (CML) was diagnosed in a 19-year-old man in 1961, and the disease remained in chronic phase, with occasional exacerbations, for 27 years. In 1976, when the first cytogenetic analysis was performed, t(9;22)(q34;q11) was found as the sole abnormality in all mitoses. During accelerated phase in 1988, a second cytogenetic investigation showed the karyotype 45,XY,t(9;22)(q34;q11),-15,-17,+der(15) t(15;17)(p13;q11). Molecular analysis revealed a rearrangement in the 5' end of the major breakpoint cluster region (M-bcr). With the case presented here, sublocalization of the bcr breakpoint has now been undertaken in altogether five CML patients with extremely long survival. It is noteworthy that in all these cases the... (More)
Chronic myeloid leukemia (CML) was diagnosed in a 19-year-old man in 1961, and the disease remained in chronic phase, with occasional exacerbations, for 27 years. In 1976, when the first cytogenetic analysis was performed, t(9;22)(q34;q11) was found as the sole abnormality in all mitoses. During accelerated phase in 1988, a second cytogenetic investigation showed the karyotype 45,XY,t(9;22)(q34;q11),-15,-17,+der(15) t(15;17)(p13;q11). Molecular analysis revealed a rearrangement in the 5' end of the major breakpoint cluster region (M-bcr). With the case presented here, sublocalization of the bcr breakpoint has now been undertaken in altogether five CML patients with extremely long survival. It is noteworthy that in all these cases the chromosome 22 breakpoint was located in the 5' region of the M-bcr. (Less)
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Leukemia
volume
4
issue
6
pages
448 - 449
publisher
Nature Publishing Group
external identifiers
  • pmid:2359344
  • scopus:0025323525
ISSN
1476-5551
language
English
LU publication?
yes
id
689853f7-e11d-47c9-a2b7-7de4e4a46f75 (old id 1105588)
date added to LUP
2016-04-01 17:06:46
date last changed
2025-04-04 15:26:27
@article{689853f7-e11d-47c9-a2b7-7de4e4a46f75,
  abstract     = {{Chronic myeloid leukemia (CML) was diagnosed in a 19-year-old man in 1961, and the disease remained in chronic phase, with occasional exacerbations, for 27 years. In 1976, when the first cytogenetic analysis was performed, t(9;22)(q34;q11) was found as the sole abnormality in all mitoses. During accelerated phase in 1988, a second cytogenetic investigation showed the karyotype 45,XY,t(9;22)(q34;q11),-15,-17,+der(15) t(15;17)(p13;q11). Molecular analysis revealed a rearrangement in the 5' end of the major breakpoint cluster region (M-bcr). With the case presented here, sublocalization of the bcr breakpoint has now been undertaken in altogether five CML patients with extremely long survival. It is noteworthy that in all these cases the chromosome 22 breakpoint was located in the 5' region of the M-bcr.}},
  author       = {{Johansson, Bertil and Mertens, Fredrik and Fioretos, Thoas and Heim, Sverre and Kristoffersson, Ulf and Mandahl, Nils and Bartram, C R and Mitelman, Felix}},
  issn         = {{1476-5551}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{448--449}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Leukemia}},
  title        = {{Remarkably long survival of a patient with Ph1-positive chronic myeloid leukemia and 5' bcr rearrangement}},
  volume       = {{4}},
  year         = {{1990}},
}