Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Skin autofluorescence, a measure of tissue accumulation of advanced glycation end products, is associated with subclinical atherosclerosis in coronary and carotid arteries

Pan, Jingxue LU ; Bao, Xue LU ; Gonçalves, Isabel LU orcid ; Jujić, Amra LU and Engström, Gunnar LU (2022) In Atherosclerosis 345. p.26-32
Abstract
Background and aims: Skin autofluorescence (AF), a measure of tissue accumulation of advanced glycation end
products (AGEs), has been associated with diabetes and cardiovascular disease. However, the association of skin
AF with subclinical coronary atherosclerosis in the general population is largely unknown. Our study aimed to
examine the associations between skin AF and subclinical atherosclerosis in coronary and carotid arteries in a
middle-aged population.
Methods: Skin AF and subclinical atherosclerosis were measured in 4416 subjects (aged 50–64 years) from the
Swedish CArdioPulmonary bioImage Study (SCAPIS). Skin AF was measured non-invasively using an auto-
fluorescence reader. Subclinical atherosclerosis... (More)
Background and aims: Skin autofluorescence (AF), a measure of tissue accumulation of advanced glycation end
products (AGEs), has been associated with diabetes and cardiovascular disease. However, the association of skin
AF with subclinical coronary atherosclerosis in the general population is largely unknown. Our study aimed to
examine the associations between skin AF and subclinical atherosclerosis in coronary and carotid arteries in a
middle-aged population.
Methods: Skin AF and subclinical atherosclerosis were measured in 4416 subjects (aged 50–64 years) from the
Swedish CArdioPulmonary bioImage Study (SCAPIS). Skin AF was measured non-invasively using an auto-
fluorescence reader. Subclinical atherosclerosis was assessed by ultrasonography of carotid arteries for evalua-
tion of carotid plaques and computed tomography for the evaluation of the coronary artery calcium score
(CACS).
Results: A total of 615 (13.9%) individuals had CACS >100 and 1340 (30.3%) subjects had bilateral carotid
plaques (median total plaque area: 8 mm2). After controlling for confounding factors, there were significant
associations between skin AF (per 1 standard deviation (SD) increase) and CACS >100: odds ratio (OR) = 1.17,
95% confidence interval (CI): 1.06–1.29, p = 0.001. Total carotid plaque area and occurrence of bilateral carotid
plaques (OR per 1 SD increase: 1.10, 95%CI: 1.01–1.19, p = 0.02) were similarly associated with skin AF after
multivariable adjustments.
Conclusions: Elevated skin AF was significantly associated with subclinical atherosclerosis in coronary and carotid
arteries independently of conventional risk factors. Skin AF, a measure of accumulation of AGEs, could be a
marker for the identification of middle-aged subjects with elevated atherosclerotic risk. (Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Atherosclerosis
volume
345
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:85124827442
  • pmid:35196628
ISSN
1879-1484
DOI
10.1016/j.atherosclerosis.2022.02.014
language
English
LU publication?
yes
id
68f25e3d-3307-4700-bcf6-fd8ffb39f126
date added to LUP
2022-02-21 09:54:08
date last changed
2023-05-11 11:04:15
@article{68f25e3d-3307-4700-bcf6-fd8ffb39f126,
  abstract     = {{Background and aims: Skin autofluorescence (AF), a measure of tissue accumulation of advanced glycation end<br/>products (AGEs), has been associated with diabetes and cardiovascular disease. However, the association of skin<br/>AF with subclinical coronary atherosclerosis in the general population is largely unknown. Our study aimed to<br/>examine the associations between skin AF and subclinical atherosclerosis in coronary and carotid arteries in a<br/>middle-aged population.<br/>Methods: Skin AF and subclinical atherosclerosis were measured in 4416 subjects (aged 50–64 years) from the<br/>Swedish CArdioPulmonary bioImage Study (SCAPIS). Skin AF was measured non-invasively using an auto-<br/>fluorescence reader. Subclinical atherosclerosis was assessed by ultrasonography of carotid arteries for evalua-<br/>tion of carotid plaques and computed tomography for the evaluation of the coronary artery calcium score<br/>(CACS).<br/>Results: A total of 615 (13.9%) individuals had CACS &gt;100 and 1340 (30.3%) subjects had bilateral carotid<br/>plaques (median total plaque area: 8 mm2). After controlling for confounding factors, there were significant<br/>associations between skin AF (per 1 standard deviation (SD) increase) and CACS &gt;100: odds ratio (OR) = 1.17,<br/>95% confidence interval (CI): 1.06–1.29, p = 0.001. Total carotid plaque area and occurrence of bilateral carotid<br/>plaques (OR per 1 SD increase: 1.10, 95%CI: 1.01–1.19, p = 0.02) were similarly associated with skin AF after<br/>multivariable adjustments.<br/>Conclusions: Elevated skin AF was significantly associated with subclinical atherosclerosis in coronary and carotid<br/>arteries independently of conventional risk factors. Skin AF, a measure of accumulation of AGEs, could be a<br/>marker for the identification of middle-aged subjects with elevated atherosclerotic risk.}},
  author       = {{Pan, Jingxue and Bao, Xue and Gonçalves, Isabel and Jujić, Amra and Engström, Gunnar}},
  issn         = {{1879-1484}},
  language     = {{eng}},
  month        = {{02}},
  pages        = {{26--32}},
  publisher    = {{Elsevier}},
  series       = {{Atherosclerosis}},
  title        = {{Skin autofluorescence, a measure of tissue accumulation of advanced glycation end products, is associated with subclinical atherosclerosis in coronary and carotid arteries}},
  url          = {{http://dx.doi.org/10.1016/j.atherosclerosis.2022.02.014}},
  doi          = {{10.1016/j.atherosclerosis.2022.02.014}},
  volume       = {{345}},
  year         = {{2022}},
}