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Attempt to establish a chronic model to study the influence of bile and pancreatic juice diversion on pancreas feedback regulation in conscious pigs

Piedra, J. L. Valverde and Pierzynowski, Stefan LU (2007) In Livestock Science2005-01-01+01:00 109(1-3). p.46-49
Abstract
The diversion of pancreatic juice and bile stimulates pancreatic exocrine secretion but the mechanism behind this process is still not clear. The present study investigates the influence of long lasting (10 h) bile diversion or pancreatic juice and bile diversion on the pancreatic secretion in conscious pigs. The experiments were performed on 4 weaned piglets, which had a catheter inserted to the accessory pancreatic duct and bile duct and two cannulas to the duodenum. The depletion of bile alone or both bile and pancreatic juice (PJ) resulted in an increased preprandial pancreatic juice outflow, as compared to controls. Bile diversion increased the pancreatic response to feeding. PJ volume, protein outflow, and trypsin activity values... (More)
The diversion of pancreatic juice and bile stimulates pancreatic exocrine secretion but the mechanism behind this process is still not clear. The present study investigates the influence of long lasting (10 h) bile diversion or pancreatic juice and bile diversion on the pancreatic secretion in conscious pigs. The experiments were performed on 4 weaned piglets, which had a catheter inserted to the accessory pancreatic duct and bile duct and two cannulas to the duodenum. The depletion of bile alone or both bile and pancreatic juice (PJ) resulted in an increased preprandial pancreatic juice outflow, as compared to controls. Bile diversion increased the pancreatic response to feeding. PJ volume, protein outflow, and trypsin activity values were significantly higher in bile diverted pigs than in control pigs during the prandial and postprandial periods. While in pancreatic juice and bile diverted piglets the PJ protein outflow and trypsin activity slightly increased in response to feeding, their values were lower than those of the control piglets. In conclusion, both pancreatic juice and bile present in the small intestine play an important role in the regulation of the pancreatic juice secretion. (c) 2007 Elsevier B.V. All fights reserved. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
bile acids, pig model, pancreatic juice feedback, bicarbonates
in
Livestock Science2005-01-01+01:00
volume
109
issue
1-3
pages
46 - 49
publisher
Elsevier
external identifiers
  • wos:000247954000011
  • scopus:34247519734
ISSN
1871-1413
DOI
10.1016/j.livsci.2007.01.056
language
English
LU publication?
yes
id
c62df637-d5cb-4cd3-8702-ea6d369c05fd (old id 691569)
date added to LUP
2007-12-19 13:59:26
date last changed
2018-05-29 09:22:19
@article{c62df637-d5cb-4cd3-8702-ea6d369c05fd,
  abstract     = {The diversion of pancreatic juice and bile stimulates pancreatic exocrine secretion but the mechanism behind this process is still not clear. The present study investigates the influence of long lasting (10 h) bile diversion or pancreatic juice and bile diversion on the pancreatic secretion in conscious pigs. The experiments were performed on 4 weaned piglets, which had a catheter inserted to the accessory pancreatic duct and bile duct and two cannulas to the duodenum. The depletion of bile alone or both bile and pancreatic juice (PJ) resulted in an increased preprandial pancreatic juice outflow, as compared to controls. Bile diversion increased the pancreatic response to feeding. PJ volume, protein outflow, and trypsin activity values were significantly higher in bile diverted pigs than in control pigs during the prandial and postprandial periods. While in pancreatic juice and bile diverted piglets the PJ protein outflow and trypsin activity slightly increased in response to feeding, their values were lower than those of the control piglets. In conclusion, both pancreatic juice and bile present in the small intestine play an important role in the regulation of the pancreatic juice secretion. (c) 2007 Elsevier B.V. All fights reserved.},
  author       = {Piedra, J. L. Valverde and Pierzynowski, Stefan},
  issn         = {1871-1413},
  keyword      = {bile acids,pig model,pancreatic juice feedback,bicarbonates},
  language     = {eng},
  number       = {1-3},
  pages        = {46--49},
  publisher    = {Elsevier},
  series       = {Livestock Science2005-01-01+01:00},
  title        = {Attempt to establish a chronic model to study the influence of bile and pancreatic juice diversion on pancreas feedback regulation in conscious pigs},
  url          = {http://dx.doi.org/10.1016/j.livsci.2007.01.056},
  volume       = {109},
  year         = {2007},
}