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Multiple factors affect the loss of measurable C-peptide over 6 years in newly diagnosed 15- to 35-year-old diabetic subjects

Jensen, Richard A.; Gilliam, Lisa K.; Törn, Carina LU ; Landin-Olsson, Mona LU ; Karlsson, F. Anders; Palmer, Jerry P.; Kockum, Ingrid; Akesson, Karin; Lernmark, Barbro LU and Lynch, Kristian LU , et al. (2007) In Journal of Diabetes and its Complications 21(4). p.205-213
Abstract
Objective: The aim of this study is to identify risk factors for the loss of measurable plasma C-peptide in newly diagnosed 15- to 35-year-old diabetic subjects. Methods: This Swedish study included 778 subjects. C-peptide levels were obtained each year for 6 years after diagnosis. Loss of measurable C-peptide was defined as a level at or below the lower detection limit of the local assay (0.13 nmol/1). In addition to C-peptide, other baseline covariates included gender, age, body mass index, HLA genotype, and autoantibody levels. Results: Compared with autoantibody-negative subjects, autoantibody-positive subjects had lower median baseline C-peptide (0.27 vs. 0.50, P<.001), their levels declined over the study period, and the risk of... (More)
Objective: The aim of this study is to identify risk factors for the loss of measurable plasma C-peptide in newly diagnosed 15- to 35-year-old diabetic subjects. Methods: This Swedish study included 778 subjects. C-peptide levels were obtained each year for 6 years after diagnosis. Loss of measurable C-peptide was defined as a level at or below the lower detection limit of the local assay (0.13 nmol/1). In addition to C-peptide, other baseline covariates included gender, age, body mass index, HLA genotype, and autoantibody levels. Results: Compared with autoantibody-negative subjects, autoantibody-positive subjects had lower median baseline C-peptide (0.27 vs. 0.50, P<.001), their levels declined over the study period, and the risk of losing measurable C-peptide was significantly higher when more than one autoantibody was present [odds ratio (OR), 4.0; 95% confidence interval (CI), 2.13-7.54]. Among autoantibody-positive individuals, the presence of GAD65Ab (OR, 1.8; 95% CI, 1.24-2.51) and islet cell antibodies (OR, 1.6; 95% CI, 1.19-2.18) conferred a higher risk for loss of measurable C-peptide.as did female gender (OR, 1.6; 95% CI, 1.17-2.11) and time after diagnosis (OR, 1.5 for each additional year postdiagnosis; 95% CI, 1.41-1.57). Higher baseline C-peptide levels were protective (OR, 0.5 for each additional log, nanomoles per liter; 95% CI, 0.36-0.58). Conclusions: This study identified autoantibody status, gender, and baseline C-peptide levels as factors that will be useful for predicting the disease course of 15- to 35-year-old diabetic individuals. (C) 2007 Elsevier Inc. All rights reserved. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
autoantibodies, c-peptide, type 1 diabetes mellitus, type 2 diabetes mellitus
in
Journal of Diabetes and its Complications
volume
21
issue
4
pages
205 - 213
publisher
Elsevier
external identifiers
  • wos:000248166100001
  • scopus:34347272254
ISSN
1873-460X
DOI
10.1016/j.jdiacomp.2006.01.004
language
English
LU publication?
yes
id
ab8cacea-93e5-4aef-a1d5-57b7e69b923c (old id 691740)
date added to LUP
2007-12-13 10:46:08
date last changed
2017-01-01 07:16:12
@article{ab8cacea-93e5-4aef-a1d5-57b7e69b923c,
  abstract     = {Objective: The aim of this study is to identify risk factors for the loss of measurable plasma C-peptide in newly diagnosed 15- to 35-year-old diabetic subjects. Methods: This Swedish study included 778 subjects. C-peptide levels were obtained each year for 6 years after diagnosis. Loss of measurable C-peptide was defined as a level at or below the lower detection limit of the local assay (0.13 nmol/1). In addition to C-peptide, other baseline covariates included gender, age, body mass index, HLA genotype, and autoantibody levels. Results: Compared with autoantibody-negative subjects, autoantibody-positive subjects had lower median baseline C-peptide (0.27 vs. 0.50, P&lt;.001), their levels declined over the study period, and the risk of losing measurable C-peptide was significantly higher when more than one autoantibody was present [odds ratio (OR), 4.0; 95% confidence interval (CI), 2.13-7.54]. Among autoantibody-positive individuals, the presence of GAD65Ab (OR, 1.8; 95% CI, 1.24-2.51) and islet cell antibodies (OR, 1.6; 95% CI, 1.19-2.18) conferred a higher risk for loss of measurable C-peptide.as did female gender (OR, 1.6; 95% CI, 1.17-2.11) and time after diagnosis (OR, 1.5 for each additional year postdiagnosis; 95% CI, 1.41-1.57). Higher baseline C-peptide levels were protective (OR, 0.5 for each additional log, nanomoles per liter; 95% CI, 0.36-0.58). Conclusions: This study identified autoantibody status, gender, and baseline C-peptide levels as factors that will be useful for predicting the disease course of 15- to 35-year-old diabetic individuals. (C) 2007 Elsevier Inc. All rights reserved.},
  author       = {Jensen, Richard A. and Gilliam, Lisa K. and Törn, Carina and Landin-Olsson, Mona and Karlsson, F. Anders and Palmer, Jerry P. and Kockum, Ingrid and Akesson, Karin and Lernmark, Barbro and Lynch, Kristian and Breslow, Norman and Lernmark, Åke},
  issn         = {1873-460X},
  keyword      = {autoantibodies,c-peptide,type 1 diabetes mellitus,type 2 diabetes mellitus},
  language     = {eng},
  number       = {4},
  pages        = {205--213},
  publisher    = {Elsevier},
  series       = {Journal of Diabetes and its Complications},
  title        = {Multiple factors affect the loss of measurable C-peptide over 6 years in newly diagnosed 15- to 35-year-old diabetic subjects},
  url          = {http://dx.doi.org/10.1016/j.jdiacomp.2006.01.004},
  volume       = {21},
  year         = {2007},
}