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A novel hollow-fibre microporous membrane liquid-liquid extraction for determination of free 4-isobutylacetophenone concentration at ultra trace level in environmental aqueous samples

Zorita, Saioa LU ; Barri, Thaer LU and Mathiasson, Lennart LU (2007) In Journal of Chromatography A 1157(1-2). p.30-37
Abstract
In this study, a method was developed for determination of the free concentration of 4-isobutylacetophenone, a toxic degradation product of ibuprofen, in river and sewage water samples from Sweden. Sample preparation and analysis were performed by a hollow-fibre microporous membrane liquid-liquid extraction (HF-MMLLE) set-up and gas chromatography-mass spectrometry (GC-MS), respectively. In this novel approach, only the liquid in the membrane pores is utilised for non-depleting extraction. Several parameters were studied, including: type of organic solvent, sample pH, and salt and humic acid content. The optimised method allowed the determination of the analyte at the ng L-1 level in river and sewage water. A linear plot gave a correlation... (More)
In this study, a method was developed for determination of the free concentration of 4-isobutylacetophenone, a toxic degradation product of ibuprofen, in river and sewage water samples from Sweden. Sample preparation and analysis were performed by a hollow-fibre microporous membrane liquid-liquid extraction (HF-MMLLE) set-up and gas chromatography-mass spectrometry (GC-MS), respectively. In this novel approach, only the liquid in the membrane pores is utilised for non-depleting extraction. Several parameters were studied, including: type of organic solvent, sample pH, and salt and humic acid content. The optimised method allowed the determination of the analyte at the ng L-1 level in river and sewage water. A linear plot gave a correlation coefficient better than 0.992 and resulted in a limit of detection of 7 and 14 ng L-1 for river and sewage water, respectively. The enrichment factor was over 2000 in the fibre and over 300 after dilution. The repeatability and reproducibility were better than 5% and 10%, respectively. For the first time, 4-isobutylacetophenone was found at free concentrations of 40 ng L-1 or below in sewage waters, while it could not be quantified in a river downstream from a municipal sewage treatment plant. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
4-isobutylacetophenone, free dissolved concentration, hollow-fibre microporous membrane liquid-liquid extraction, sewage water
in
Journal of Chromatography A
volume
1157
issue
1-2
pages
30 - 37
publisher
Elsevier
external identifiers
  • wos:000248107200005
  • scopus:34250752874
ISSN
0021-9673
DOI
10.1016/j.chroma.2007.05.039
language
English
LU publication?
yes
id
d01cce52-4d3d-4d39-bde3-bc9c62765685 (old id 691798)
date added to LUP
2007-12-19 11:36:34
date last changed
2017-07-30 04:47:03
@article{d01cce52-4d3d-4d39-bde3-bc9c62765685,
  abstract     = {In this study, a method was developed for determination of the free concentration of 4-isobutylacetophenone, a toxic degradation product of ibuprofen, in river and sewage water samples from Sweden. Sample preparation and analysis were performed by a hollow-fibre microporous membrane liquid-liquid extraction (HF-MMLLE) set-up and gas chromatography-mass spectrometry (GC-MS), respectively. In this novel approach, only the liquid in the membrane pores is utilised for non-depleting extraction. Several parameters were studied, including: type of organic solvent, sample pH, and salt and humic acid content. The optimised method allowed the determination of the analyte at the ng L-1 level in river and sewage water. A linear plot gave a correlation coefficient better than 0.992 and resulted in a limit of detection of 7 and 14 ng L-1 for river and sewage water, respectively. The enrichment factor was over 2000 in the fibre and over 300 after dilution. The repeatability and reproducibility were better than 5% and 10%, respectively. For the first time, 4-isobutylacetophenone was found at free concentrations of 40 ng L-1 or below in sewage waters, while it could not be quantified in a river downstream from a municipal sewage treatment plant.},
  author       = {Zorita, Saioa and Barri, Thaer and Mathiasson, Lennart},
  issn         = {0021-9673},
  keyword      = {4-isobutylacetophenone,free dissolved concentration,hollow-fibre microporous membrane liquid-liquid extraction,sewage water},
  language     = {eng},
  number       = {1-2},
  pages        = {30--37},
  publisher    = {Elsevier},
  series       = {Journal of Chromatography A},
  title        = {A novel hollow-fibre microporous membrane liquid-liquid extraction for determination of free 4-isobutylacetophenone concentration at ultra trace level in environmental aqueous samples},
  url          = {http://dx.doi.org/10.1016/j.chroma.2007.05.039},
  volume       = {1157},
  year         = {2007},
}