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A locus on chromosome 20 encompassing genes that are highly expressed in the epididymis

Lundwall, Åke LU (2007) In Asian Journal of Andrology 9(4). p.540-544
Abstract
During liquefaction of the ejaculate, the semen coagulum proteins semenogelin I (SEMG1) and semenogelin II (SEMG2) are degraded to low molecular mass fragments by kallikrein-related peptidase 3 (KLK3), also known as prostate-specific antigen. Semenogelin molecules initiate their own destruction by chelating Zn2+ that normally would completely inhibit the proteolytic activity of KLK3. In a similar way, semenogelins might regulate the activity of kallikrein-related peptidases in the epididymis, something that might be of importance for the maturation of spermatozoa or generation of anti-bacterial peptides. Studies on the evolution of semen coagulum proteins have revealed that most of them carry an exon that displays a rapid and unusual... (More)
During liquefaction of the ejaculate, the semen coagulum proteins semenogelin I (SEMG1) and semenogelin II (SEMG2) are degraded to low molecular mass fragments by kallikrein-related peptidase 3 (KLK3), also known as prostate-specific antigen. Semenogelin molecules initiate their own destruction by chelating Zn2+ that normally would completely inhibit the proteolytic activity of KLK3. In a similar way, semenogelins might regulate the activity of kallikrein-related peptidases in the epididymis, something that might be of importance for the maturation of spermatozoa or generation of anti-bacterial peptides. Studies on the evolution of semen coagulum proteins have revealed that most of them carry an exon that displays a rapid and unusual evolution. As a consequence, homologous proteins in rodents and primates show almost no conservation in primary structure. Further studies on their evolution suggest that the progenitor of the semen coagulum proteins probably was a protease inhibitor that might have displayed antimicrobial activity. The semenogelin locus on chromosome 20 contains at least 17 homologous genes encoding probable protease inhibitors with homology to semen coagulum proteins. All of these are highly expressed in the epididymis where they, similar to the semenogelins, could affect the maturation of spermatozoa or display antibacterial properties. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
proteolysis, kunitz, antimicrobial, semenogelin, inhibitor, semen, whey acidic protein four disulphide core, zinc
in
Asian Journal of Andrology
volume
9
issue
4
pages
540 - 544
publisher
Nature Publishing Group
external identifiers
  • wos:000247752800015
  • scopus:34447265232
ISSN
1008-682X
DOI
10.1111/j.1745-7262.2007.00303.x
language
English
LU publication?
yes
id
2fe8e28b-4054-4c76-90fd-780b055c5cca (old id 692906)
date added to LUP
2007-12-13 11:20:29
date last changed
2017-01-01 04:42:18
@article{2fe8e28b-4054-4c76-90fd-780b055c5cca,
  abstract     = {During liquefaction of the ejaculate, the semen coagulum proteins semenogelin I (SEMG1) and semenogelin II (SEMG2) are degraded to low molecular mass fragments by kallikrein-related peptidase 3 (KLK3), also known as prostate-specific antigen. Semenogelin molecules initiate their own destruction by chelating Zn2+ that normally would completely inhibit the proteolytic activity of KLK3. In a similar way, semenogelins might regulate the activity of kallikrein-related peptidases in the epididymis, something that might be of importance for the maturation of spermatozoa or generation of anti-bacterial peptides. Studies on the evolution of semen coagulum proteins have revealed that most of them carry an exon that displays a rapid and unusual evolution. As a consequence, homologous proteins in rodents and primates show almost no conservation in primary structure. Further studies on their evolution suggest that the progenitor of the semen coagulum proteins probably was a protease inhibitor that might have displayed antimicrobial activity. The semenogelin locus on chromosome 20 contains at least 17 homologous genes encoding probable protease inhibitors with homology to semen coagulum proteins. All of these are highly expressed in the epididymis where they, similar to the semenogelins, could affect the maturation of spermatozoa or display antibacterial properties.},
  author       = {Lundwall, Åke},
  issn         = {1008-682X},
  keyword      = {proteolysis,kunitz,antimicrobial,semenogelin,inhibitor,semen,whey acidic protein four disulphide core,zinc},
  language     = {eng},
  number       = {4},
  pages        = {540--544},
  publisher    = {Nature Publishing Group},
  series       = {Asian Journal of Andrology},
  title        = {A locus on chromosome 20 encompassing genes that are highly expressed in the epididymis},
  url          = {http://dx.doi.org/10.1111/j.1745-7262.2007.00303.x},
  volume       = {9},
  year         = {2007},
}