Neuropathological postmortem evaluation of BNCT for GBM
(2007) In Acta Neurologica Scandinavica 116(3). p.169-176- Abstract
- Background - Thirty patients with glioblastoma multiforme (GBM) were treated by boron neutron capture therapy (BNCT) at the Studsvik facility in Sweden, in a clinical trial exploring a procedure in which 900 mg p-boronophenylalanine (BPA) per kilo body weight was infused in 6 h. Objective - The present study was designed to assess tumor efficacy and radiation damage to the brain for the seven patients in the Studsvik trial that were available for postmortem neuropathological examination. Method - Whole brain slices containing the initial tumor site and other regions showing pathological changes were chosen for microscopy and selected areas were studied by immunological methods. Results - Local control of GBM was observed in all cases.... (More)
- Background - Thirty patients with glioblastoma multiforme (GBM) were treated by boron neutron capture therapy (BNCT) at the Studsvik facility in Sweden, in a clinical trial exploring a procedure in which 900 mg p-boronophenylalanine (BPA) per kilo body weight was infused in 6 h. Objective - The present study was designed to assess tumor efficacy and radiation damage to the brain for the seven patients in the Studsvik trial that were available for postmortem neuropathological examination. Method - Whole brain slices containing the initial tumor site and other regions showing pathological changes were chosen for microscopy and selected areas were studied by immunological methods. Results - Local control of GBM was observed in all cases. Conclusive evidence for radiation induced brain damage was not found. Conclusion - Using a novel procedure for BPA infusion, BNCT achieves local control of GBM for minimum tumor doses as low as 15 wGy, allowing treatment with very low concomitant doses to surrounding healthy tissues. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/692991
- author
- H-Stenstam, B. ; Pellettieri, L. ; Skold, K. ; Rezaei, A. and Brun, Arne LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- boron neutron capture therapy, glioblastoma multiforme, postmortem, evaluation
- in
- Acta Neurologica Scandinavica
- volume
- 116
- issue
- 3
- pages
- 169 - 176
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000248760900006
- scopus:34547876840
- pmid:17714330
- ISSN
- 1600-0404
- DOI
- 10.1111/j.1600-0404.2007.00837.x
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000)
- id
- e59b3955-c5e6-46a7-b39b-ad1936329a6f (old id 692991)
- date added to LUP
- 2016-04-01 17:09:00
- date last changed
- 2022-01-29 00:44:34
@article{e59b3955-c5e6-46a7-b39b-ad1936329a6f, abstract = {{Background - Thirty patients with glioblastoma multiforme (GBM) were treated by boron neutron capture therapy (BNCT) at the Studsvik facility in Sweden, in a clinical trial exploring a procedure in which 900 mg p-boronophenylalanine (BPA) per kilo body weight was infused in 6 h. Objective - The present study was designed to assess tumor efficacy and radiation damage to the brain for the seven patients in the Studsvik trial that were available for postmortem neuropathological examination. Method - Whole brain slices containing the initial tumor site and other regions showing pathological changes were chosen for microscopy and selected areas were studied by immunological methods. Results - Local control of GBM was observed in all cases. Conclusive evidence for radiation induced brain damage was not found. Conclusion - Using a novel procedure for BPA infusion, BNCT achieves local control of GBM for minimum tumor doses as low as 15 wGy, allowing treatment with very low concomitant doses to surrounding healthy tissues.}}, author = {{H-Stenstam, B. and Pellettieri, L. and Skold, K. and Rezaei, A. and Brun, Arne}}, issn = {{1600-0404}}, keywords = {{boron neutron capture therapy; glioblastoma multiforme; postmortem; evaluation}}, language = {{eng}}, number = {{3}}, pages = {{169--176}}, publisher = {{Wiley-Blackwell}}, series = {{Acta Neurologica Scandinavica}}, title = {{Neuropathological postmortem evaluation of BNCT for GBM}}, url = {{http://dx.doi.org/10.1111/j.1600-0404.2007.00837.x}}, doi = {{10.1111/j.1600-0404.2007.00837.x}}, volume = {{116}}, year = {{2007}}, }