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Neuropathological postmortem evaluation of BNCT for GBM

H-Stenstam, B.; Pellettieri, L.; Skold, K.; Rezaei, A. and Brun, Arne LU (2007) In Acta Neurologica Scandinavica 116(3). p.169-176
Abstract
Background - Thirty patients with glioblastoma multiforme (GBM) were treated by boron neutron capture therapy (BNCT) at the Studsvik facility in Sweden, in a clinical trial exploring a procedure in which 900 mg p-boronophenylalanine (BPA) per kilo body weight was infused in 6 h. Objective - The present study was designed to assess tumor efficacy and radiation damage to the brain for the seven patients in the Studsvik trial that were available for postmortem neuropathological examination. Method - Whole brain slices containing the initial tumor site and other regions showing pathological changes were chosen for microscopy and selected areas were studied by immunological methods. Results - Local control of GBM was observed in all cases.... (More)
Background - Thirty patients with glioblastoma multiforme (GBM) were treated by boron neutron capture therapy (BNCT) at the Studsvik facility in Sweden, in a clinical trial exploring a procedure in which 900 mg p-boronophenylalanine (BPA) per kilo body weight was infused in 6 h. Objective - The present study was designed to assess tumor efficacy and radiation damage to the brain for the seven patients in the Studsvik trial that were available for postmortem neuropathological examination. Method - Whole brain slices containing the initial tumor site and other regions showing pathological changes were chosen for microscopy and selected areas were studied by immunological methods. Results - Local control of GBM was observed in all cases. Conclusive evidence for radiation induced brain damage was not found. Conclusion - Using a novel procedure for BPA infusion, BNCT achieves local control of GBM for minimum tumor doses as low as 15 wGy, allowing treatment with very low concomitant doses to surrounding healthy tissues. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
boron neutron capture therapy, glioblastoma multiforme, postmortem, evaluation
in
Acta Neurologica Scandinavica
volume
116
issue
3
pages
169 - 176
publisher
Wiley-Blackwell
external identifiers
  • wos:000248760900006
  • scopus:34547876840
ISSN
1600-0404
DOI
10.1111/j.1600-0404.2007.00837.x
language
English
LU publication?
yes
id
e59b3955-c5e6-46a7-b39b-ad1936329a6f (old id 692991)
date added to LUP
2007-12-10 16:13:18
date last changed
2017-01-01 07:25:37
@article{e59b3955-c5e6-46a7-b39b-ad1936329a6f,
  abstract     = {Background - Thirty patients with glioblastoma multiforme (GBM) were treated by boron neutron capture therapy (BNCT) at the Studsvik facility in Sweden, in a clinical trial exploring a procedure in which 900 mg p-boronophenylalanine (BPA) per kilo body weight was infused in 6 h. Objective - The present study was designed to assess tumor efficacy and radiation damage to the brain for the seven patients in the Studsvik trial that were available for postmortem neuropathological examination. Method - Whole brain slices containing the initial tumor site and other regions showing pathological changes were chosen for microscopy and selected areas were studied by immunological methods. Results - Local control of GBM was observed in all cases. Conclusive evidence for radiation induced brain damage was not found. Conclusion - Using a novel procedure for BPA infusion, BNCT achieves local control of GBM for minimum tumor doses as low as 15 wGy, allowing treatment with very low concomitant doses to surrounding healthy tissues.},
  author       = {H-Stenstam, B. and Pellettieri, L. and Skold, K. and Rezaei, A. and Brun, Arne},
  issn         = {1600-0404},
  keyword      = {boron neutron capture therapy,glioblastoma multiforme,postmortem,evaluation},
  language     = {eng},
  number       = {3},
  pages        = {169--176},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Neurologica Scandinavica},
  title        = {Neuropathological postmortem evaluation of BNCT for GBM},
  url          = {http://dx.doi.org/10.1111/j.1600-0404.2007.00837.x},
  volume       = {116},
  year         = {2007},
}