First-year mortality in incident dialysis patients : results of the Peridialysis study
Heaf, James ; Heiro, Maija ; Petersons, Aivars ; Vernere, Baiba ; Povlsen, Johan V ; Sørensen, Anette Bagger ; Clyne, Naomi LU
; Bumblyte, Inga
; Zilinskiene, Alanta
and Randers, Else
, et al.
(2022)
In BMC Nephrology
23(1).
- Abstract
BACKGROUND: Controversy surrounds which factors are important for predicting early mortality after dialysis initiation (DI). We investigated associations of predialysis course and circumstances affecting planning and execution of DI with mortality following DI.
METHODS: Among 1580 patients participating in the Peridialysis study, a study of causes and timing of DI, we registered features of predialysis course, clinical and biochemical data at DI, incidence of unplanned suboptimal DI, contraindications to peritoneal dialysis (PD) or hemodialysis (HD), and modality preference, actual choice, and cause of modality choice. Patients were followed for 12 months or until transplantation. A flexible parametric model was used to identify... (More)
BACKGROUND: Controversy surrounds which factors are important for predicting early mortality after dialysis initiation (DI). We investigated associations of predialysis course and circumstances affecting planning and execution of DI with mortality following DI.
METHODS: Among 1580 patients participating in the Peridialysis study, a study of causes and timing of DI, we registered features of predialysis course, clinical and biochemical data at DI, incidence of unplanned suboptimal DI, contraindications to peritoneal dialysis (PD) or hemodialysis (HD), and modality preference, actual choice, and cause of modality choice. Patients were followed for 12 months or until transplantation. A flexible parametric model was used to identify independent factors associated with all-cause mortality.
RESULTS: First-year mortality was 19.33%. Independent factors predicting death were high age, comorbidity, clinical contraindications to PD or HD, suboptimal DI, high eGFR, low serum albumin, hyperphosphatemia, high C-reactive protein, signs of overhydration and cerebral symptoms at DI. Among 1061 (67.2%) patients who could select dialysis modality based on personal choice, 654 (61.6%) chose PD, 368 (34.7%) center HD and 39 (3.7%) home HD. The 12-months survival did not differ significantly between patients receiving PD and in-center HD.
CONCLUSIONS: First-year mortality in incident dialysis patients was in addition to high age and comorbidity, associated with clinical contraindications to PD or HD, clinical symptoms, hyperphosphatemia, inflammation, and suboptimal DI. In patients with a "free" choice of dialysis modality based on their personal preferences, PD and in-center HD led to broadly similar short-term outcomes.
(Less)
- author
- Heaf, James
; Heiro, Maija
; Petersons, Aivars
; Vernere, Baiba
; Povlsen, Johan V
; Sørensen, Anette Bagger
; Clyne, Naomi
LU
; Bumblyte, Inga
; Zilinskiene, Alanta
and Randers, Else
, et al. (More)
- Heaf, James
; Heiro, Maija
; Petersons, Aivars
; Vernere, Baiba
; Povlsen, Johan V
; Sørensen, Anette Bagger
; Clyne, Naomi
LU
; Bumblyte, Inga
; Zilinskiene, Alanta
; Randers, Else
; Løkkegaard, Niels
; Rosenberg, Mai
; Kjellevold, Stig
; Kampmann, Jan Dominik
; Rogland, Björn
; Lagreid, Inger
; Heimburger, Olof
; Qureshi, Abdul Rashid
and Lindholm, Bengt
(Less)
- organization
- publishing date
- 2022-06-27
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Humans, Hyperphosphatemia/etiology, Incidence, Kidney Failure, Chronic, Peritoneal Dialysis/adverse effects, Renal Dialysis/methods
- in
- BMC Nephrology
- volume
- 23
- issue
- 1
- article number
- 229
- publisher
- BioMed Central (BMC)
- external identifiers
-
- pmid:35761193
- scopus:85132950705
- ISSN
- 1471-2369
- DOI
- 10.1186/s12882-022-02852-1
- language
- English
- LU publication?
- yes
- id
- 693d12e9-d3d5-443f-9682-84ed054cfa54
- date added to LUP
- 2022-07-09 19:20:35
- date last changed
- 2024-04-18 12:52:18
@article{693d12e9-d3d5-443f-9682-84ed054cfa54,
abstract = {{<p>BACKGROUND: Controversy surrounds which factors are important for predicting early mortality after dialysis initiation (DI). We investigated associations of predialysis course and circumstances affecting planning and execution of DI with mortality following DI.</p><p>METHODS: Among 1580 patients participating in the Peridialysis study, a study of causes and timing of DI, we registered features of predialysis course, clinical and biochemical data at DI, incidence of unplanned suboptimal DI, contraindications to peritoneal dialysis (PD) or hemodialysis (HD), and modality preference, actual choice, and cause of modality choice. Patients were followed for 12 months or until transplantation. A flexible parametric model was used to identify independent factors associated with all-cause mortality.</p><p>RESULTS: First-year mortality was 19.33%. Independent factors predicting death were high age, comorbidity, clinical contraindications to PD or HD, suboptimal DI, high eGFR, low serum albumin, hyperphosphatemia, high C-reactive protein, signs of overhydration and cerebral symptoms at DI. Among 1061 (67.2%) patients who could select dialysis modality based on personal choice, 654 (61.6%) chose PD, 368 (34.7%) center HD and 39 (3.7%) home HD. The 12-months survival did not differ significantly between patients receiving PD and in-center HD.</p><p>CONCLUSIONS: First-year mortality in incident dialysis patients was in addition to high age and comorbidity, associated with clinical contraindications to PD or HD, clinical symptoms, hyperphosphatemia, inflammation, and suboptimal DI. In patients with a "free" choice of dialysis modality based on their personal preferences, PD and in-center HD led to broadly similar short-term outcomes.</p>}},
author = {{Heaf, James and Heiro, Maija and Petersons, Aivars and Vernere, Baiba and Povlsen, Johan V and Sørensen, Anette Bagger and Clyne, Naomi and Bumblyte, Inga and Zilinskiene, Alanta and Randers, Else and Løkkegaard, Niels and Rosenberg, Mai and Kjellevold, Stig and Kampmann, Jan Dominik and Rogland, Björn and Lagreid, Inger and Heimburger, Olof and Qureshi, Abdul Rashid and Lindholm, Bengt}},
issn = {{1471-2369}},
keywords = {{Humans; Hyperphosphatemia/etiology; Incidence; Kidney Failure, Chronic; Peritoneal Dialysis/adverse effects; Renal Dialysis/methods}},
language = {{eng}},
month = {{06}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Nephrology}},
title = {{First-year mortality in incident dialysis patients : results of the Peridialysis study}},
url = {{http://dx.doi.org/10.1186/s12882-022-02852-1}},
doi = {{10.1186/s12882-022-02852-1}},
volume = {{23}},
year = {{2022}},
}