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Effect of temperature on the association behavior in aqueous mixtures of an oppositely charged amphiphilic block copolymer and bile salt

Du, Guanqun LU ; Del Giudice, Alessandra LU orcid ; Alfredsson, Viveka LU ; Carnerup, Anna M. LU ; Pavel, Nicolae V. ; Loh, Watson LU ; Masci, Giancarlo ; Nyström, Bo ; Galantini, Luciano and Schillén, Karin LU orcid (2020) In Polymer 206.
Abstract

The association in aqueous mixtures of a thermoresponsive cationic diblock copolymer composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(3-acrylamidopropyl)-trimethylammonium-chloride (PAMPTMA(+)) and the oppositely charged bile salt sodium deoxycholate (NaDC) is investigated at different compositions by light and X-ray scattering, calorimetry, and electrophoretic mobility measurements. Clouding reveals aggregation upon heating. The addition of NaDC to the copolymer solution lowers the temperature of the transition and increases its cooperativity. At high temperature and low NaDC fractions, mixed aggregates with a dehydrated PNIPAM-rich interior and a PAMPTMA(+)-rich shell partially neutralized by DC– anions are formed.... (More)

The association in aqueous mixtures of a thermoresponsive cationic diblock copolymer composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(3-acrylamidopropyl)-trimethylammonium-chloride (PAMPTMA(+)) and the oppositely charged bile salt sodium deoxycholate (NaDC) is investigated at different compositions by light and X-ray scattering, calorimetry, and electrophoretic mobility measurements. Clouding reveals aggregation upon heating. The addition of NaDC to the copolymer solution lowers the temperature of the transition and increases its cooperativity. At high temperature and low NaDC fractions, mixed aggregates with a dehydrated PNIPAM-rich interior and a PAMPTMA(+)-rich shell partially neutralized by DC– anions are formed. At high NaDC fractions, the aggregates present internal regularly spaced segregated nanoregions of dehydrated PNIPAM and PAMPTMA(+)/DC– (microphase separation). The results suggest that the mixed aggregates have appealing composition-controlled thermoresponse. The system phase separates at body temperature and the highest NaDC fractions investigated, meaning in conditions accomplished when the use of the polymer as a bile salt sequestrant is hypothesized.

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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bile salts, Cationic thermoresponsive block copolymers, Oppositely charged polymer-surfactant systems
in
Polymer
volume
206
article number
122871
publisher
Elsevier
external identifiers
  • scopus:85090129803
ISSN
0032-3861
DOI
10.1016/j.polymer.2020.122871
language
English
LU publication?
yes
id
695e48b7-8003-4738-8657-73c264e4d0f2
date added to LUP
2020-09-14 13:58:25
date last changed
2022-04-19 00:44:37
@article{695e48b7-8003-4738-8657-73c264e4d0f2,
  abstract     = {{<p>The association in aqueous mixtures of a thermoresponsive cationic diblock copolymer composed of poly(N-isopropylacrylamide) (PNIPAM) and poly(3-acrylamidopropyl)-trimethylammonium-chloride (PAMPTMA(+)) and the oppositely charged bile salt sodium deoxycholate (NaDC) is investigated at different compositions by light and X-ray scattering, calorimetry, and electrophoretic mobility measurements. Clouding reveals aggregation upon heating. The addition of NaDC to the copolymer solution lowers the temperature of the transition and increases its cooperativity. At high temperature and low NaDC fractions, mixed aggregates with a dehydrated PNIPAM-rich interior and a PAMPTMA(+)-rich shell partially neutralized by DC<sup>–</sup> anions are formed. At high NaDC fractions, the aggregates present internal regularly spaced segregated nanoregions of dehydrated PNIPAM and PAMPTMA(+)/DC<sup>–</sup> (microphase separation). The results suggest that the mixed aggregates have appealing composition-controlled thermoresponse. The system phase separates at body temperature and the highest NaDC fractions investigated, meaning in conditions accomplished when the use of the polymer as a bile salt sequestrant is hypothesized.</p>}},
  author       = {{Du, Guanqun and Del Giudice, Alessandra and Alfredsson, Viveka and Carnerup, Anna M. and Pavel, Nicolae V. and Loh, Watson and Masci, Giancarlo and Nyström, Bo and Galantini, Luciano and Schillén, Karin}},
  issn         = {{0032-3861}},
  keywords     = {{Bile salts; Cationic thermoresponsive block copolymers; Oppositely charged polymer-surfactant systems}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Polymer}},
  title        = {{Effect of temperature on the association behavior in aqueous mixtures of an oppositely charged amphiphilic block copolymer and bile salt}},
  url          = {{http://dx.doi.org/10.1016/j.polymer.2020.122871}},
  doi          = {{10.1016/j.polymer.2020.122871}},
  volume       = {{206}},
  year         = {{2020}},
}