Clinical effects of initial 6 months monotherapy with bisoprolol versus enalapril in the treatment of patients with mild to moderate chronic heart failure. Data from the CIBIS III trial
(2008) In Cardiovascular Drugs and Therapy 22(5). p.399-405- Abstract
- Purpose To assess the clinical effects and safety profile of initial monotherapy with either bisoprolol or enalapril in elderly patients with heart failure (HF). Methods In CIBIS III, 1010 patients with mild to moderate HF and age >= 65 years were randomized to monotherapy with either bisoprolol or enalapril for 6 months. Results Bisoprolol had a similar effect as enalapril on the combined end-point of all-cause mortality or hospitalization (HR 1.02; p=0.90), as well as on each of the individual end-points. A trend towards fewer sudden deaths was observed with bisoprolol (NS). On the other hand, more cases of worsening HF requiring hospitalization or occurring while in hospital were observed in the bisoprolol group (HR 1.67; p=0.03).... (More)
- Purpose To assess the clinical effects and safety profile of initial monotherapy with either bisoprolol or enalapril in elderly patients with heart failure (HF). Methods In CIBIS III, 1010 patients with mild to moderate HF and age >= 65 years were randomized to monotherapy with either bisoprolol or enalapril for 6 months. Results Bisoprolol had a similar effect as enalapril on the combined end-point of all-cause mortality or hospitalization (HR 1.02; p=0.90), as well as on each of the individual end-points. A trend towards fewer sudden deaths was observed with bisoprolol (NS). On the other hand, more cases of worsening HF requiring hospitalization or occurring while in hospital were observed in the bisoprolol group (HR 1.67; p=0.03). The two groups were similar with regard to treatment cessations and early introduction of the second drug. Conclusions Bisoprolol and enalapril had a similar effect on the combined end-point of mortality or hospitalization during 6 months monotherapy. However, more worsening HF events were observed in the bisoprolol group. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1247303
- author
- Dobre, Daniela ; van Veldhuisen, Dirk J. ; Goulder, Michael A. ; Krum, Henry and Willenheimer, Ronnie LU
- organization
- publishing date
- 2008
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- CIBISIII, enalapril, heart failure, bisoprolol
- in
- Cardiovascular Drugs and Therapy
- volume
- 22
- issue
- 5
- pages
- 399 - 405
- publisher
- Springer
- external identifiers
-
- wos:000258958300009
- scopus:51349155508
- pmid:18528751
- ISSN
- 0920-3206
- DOI
- 10.1007/s10557-008-6116-9
- language
- English
- LU publication?
- yes
- id
- 69b7e4ab-dd25-4609-a3ff-18792ed8d62e (old id 1247303)
- date added to LUP
- 2016-04-01 13:20:23
- date last changed
- 2025-04-04 15:31:02
@article{69b7e4ab-dd25-4609-a3ff-18792ed8d62e,
abstract = {{Purpose To assess the clinical effects and safety profile of initial monotherapy with either bisoprolol or enalapril in elderly patients with heart failure (HF). Methods In CIBIS III, 1010 patients with mild to moderate HF and age >= 65 years were randomized to monotherapy with either bisoprolol or enalapril for 6 months. Results Bisoprolol had a similar effect as enalapril on the combined end-point of all-cause mortality or hospitalization (HR 1.02; p=0.90), as well as on each of the individual end-points. A trend towards fewer sudden deaths was observed with bisoprolol (NS). On the other hand, more cases of worsening HF requiring hospitalization or occurring while in hospital were observed in the bisoprolol group (HR 1.67; p=0.03). The two groups were similar with regard to treatment cessations and early introduction of the second drug. Conclusions Bisoprolol and enalapril had a similar effect on the combined end-point of mortality or hospitalization during 6 months monotherapy. However, more worsening HF events were observed in the bisoprolol group.}},
author = {{Dobre, Daniela and van Veldhuisen, Dirk J. and Goulder, Michael A. and Krum, Henry and Willenheimer, Ronnie}},
issn = {{0920-3206}},
keywords = {{CIBISIII; enalapril; heart failure; bisoprolol}},
language = {{eng}},
number = {{5}},
pages = {{399--405}},
publisher = {{Springer}},
series = {{Cardiovascular Drugs and Therapy}},
title = {{Clinical effects of initial 6 months monotherapy with bisoprolol versus enalapril in the treatment of patients with mild to moderate chronic heart failure. Data from the CIBIS III trial}},
url = {{http://dx.doi.org/10.1007/s10557-008-6116-9}},
doi = {{10.1007/s10557-008-6116-9}},
volume = {{22}},
year = {{2008}},
}