RIFM fragrance ingredient safety assessment dihydro-β-terpinyl acetate, CAS Registry Number 26252-11-9
(2018) In Food and Chemical Toxicology 115. p.206-213- Abstract
Summary: The use of this material under current conditions is supported by existing information. The material (dihydro-β-terpinyl acetate) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the read across analog menthyl acetate (1α,2β,5α) (CAS # 89-48-5) show that dihydro-β- terpinyl acetate is not genotoxic nor does it have skin sensitization potential. The repeated dose, reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The... (More)
Summary: The use of this material under current conditions is supported by existing information. The material (dihydro-β-terpinyl acetate) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the read across analog menthyl acetate (1α,2β,5α) (CAS # 89-48-5) show that dihydro-β- terpinyl acetate is not genotoxic nor does it have skin sensitization potential. The repeated dose, reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on UV spectra. The environmental endpoints were evaluated, dihydro-β-terpinyl acetate was found not to be PBT as per the IFRA Environmental Standards and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC) are <1.
(Less)
- author
- publishing date
- 2018-02-17
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Environmental safety, Local respiratory toxicity, Phototoxicity/photoallergencity, Repeated dose, developmental and reproductive toxicity, Skin sensitization
- in
- Food and Chemical Toxicology
- volume
- 115
- pages
- 206 - 213
- publisher
- Elsevier
- external identifiers
-
- pmid:29408617
- scopus:85042139485
- ISSN
- 0278-6915
- DOI
- 10.1016/j.fct.2018.01.037
- language
- English
- LU publication?
- no
- id
- 69d2093f-403c-435d-b107-42bf9e751b93
- date added to LUP
- 2018-03-07 12:17:45
- date last changed
- 2024-06-24 11:03:28
@article{69d2093f-403c-435d-b107-42bf9e751b93, abstract = {{<p>Summary: The use of this material under current conditions is supported by existing information. The material (dihydro-β-terpinyl acetate) was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity/photoallergenicity, skin sensitization, as well as environmental safety. Data from the read across analog menthyl acetate (1α,2β,5α) (CAS # 89-48-5) show that dihydro-β- terpinyl acetate is not genotoxic nor does it have skin sensitization potential. The repeated dose, reproductive and local respiratory toxicity endpoints were completed using the TTC (Threshold of Toxicological Concern) for a Cramer Class I material (0.03, 0.03 mg/kg/day and 1.4 mg/day, respectively). The phototoxicity/photoallergenicity endpoint was completed based on UV spectra. The environmental endpoints were evaluated, dihydro-β-terpinyl acetate was found not to be PBT as per the IFRA Environmental Standards and its risk quotients, based on its current volume of use in Europe and North America (i.e., PEC/PNEC) are <1.</p>}}, author = {{Api, A. M. and Belsito, D. and Botelho, D. and Browne, D. and Bruze, M. and Burton, G. A. and Buschmann, J. and Dagli, M. L. and Date, M. and Dekant, W. and Deodhar, C. and Francis, M. and Fryer, A. D. and Joshi, K. and La Cava, S. and Lapczynski, A. and Liebler, D. C. and O'Brien, D. and Parakhia, R. and Patel, A. and Penning, T. M. and Ritacco, G. and Romine, J. and Salvito, D. and Schultz, T. W. and Sipes, I. G. and Thakkar, Y. and Theophilus, E. H. and Tiethof, A. K. and Tokura, Y. and Tsang, S. and Wahler, J.}}, issn = {{0278-6915}}, keywords = {{Environmental safety; Local respiratory toxicity; Phototoxicity/photoallergencity; Repeated dose, developmental and reproductive toxicity; Skin sensitization}}, language = {{eng}}, month = {{02}}, pages = {{206--213}}, publisher = {{Elsevier}}, series = {{Food and Chemical Toxicology}}, title = {{RIFM fragrance ingredient safety assessment dihydro-β-terpinyl acetate, CAS Registry Number 26252-11-9}}, url = {{http://dx.doi.org/10.1016/j.fct.2018.01.037}}, doi = {{10.1016/j.fct.2018.01.037}}, volume = {{115}}, year = {{2018}}, }