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Morphology-based sorting-blood cells and parasites

Beech, Jason P. LU ; Holm, Stefan LU ; Barrett, Michael P. and Tegenfeldt, Jonas O. LU orcid (2010) 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 2. p.1343-1345
Abstract

Morphology represents a hitherto unexploited source of specificity in microfluidic particle separation and may serve as the basis for label-free particle fractionation. There is a wealth of morphological changes in blood cells due to a wide range of clinical conditions, diseases, medication and other factors. Also, blood-borne parasites differ in morphology from blood cells. We present the use of Deterministic Lateral Displacement to create a chip-based, label-free diagnostic tool, capable of harvesting some of the wealth of information locked away in red blood cell morphology. We also use the device to separate the parasites that cause sleeping sickness from blood.

Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
Deterministic lateral displacement, Erythrocytes, Morphology, Separation, Trypanosomiasis
host publication
14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
volume
2
pages
3 pages
conference name
14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010
conference location
Groningen, Netherlands
conference dates
2010-10-03 - 2010-10-07
external identifiers
  • scopus:84884365878
ISBN
9781618390622
language
English
LU publication?
yes
id
6a53e261-b5bb-46b3-a092-3cc94a8d260d
date added to LUP
2018-10-20 10:13:18
date last changed
2023-09-08 09:27:53
@inproceedings{6a53e261-b5bb-46b3-a092-3cc94a8d260d,
  abstract     = {{<p>Morphology represents a hitherto unexploited source of specificity in microfluidic particle separation and may serve as the basis for label-free particle fractionation. There is a wealth of morphological changes in blood cells due to a wide range of clinical conditions, diseases, medication and other factors. Also, blood-borne parasites differ in morphology from blood cells. We present the use of Deterministic Lateral Displacement to create a chip-based, label-free diagnostic tool, capable of harvesting some of the wealth of information locked away in red blood cell morphology. We also use the device to separate the parasites that cause sleeping sickness from blood.</p>}},
  author       = {{Beech, Jason P. and Holm, Stefan and Barrett, Michael P. and Tegenfeldt, Jonas O.}},
  booktitle    = {{14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010}},
  isbn         = {{9781618390622}},
  keywords     = {{Deterministic lateral displacement; Erythrocytes; Morphology; Separation; Trypanosomiasis}},
  language     = {{eng}},
  month        = {{12}},
  pages        = {{1343--1345}},
  title        = {{Morphology-based sorting-blood cells and parasites}},
  volume       = {{2}},
  year         = {{2010}},
}