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The Genetics of Urinary Tract Infections and the Innate Defense of the Kidney and Urinary tract

Ambite, Ines LU orcid ; RYDSTRÖM, GUSTAV LU ; Schwaderer, Andrew L and Hains, David S (2016) In Journal of pediatric genetics 5(1). p.25-32
Abstract

The urinary tract is a sterile organ system. Urinary tract infections (UTIs) are common and often serious infections. Research has focused on uropathogen, environment, and host factors leading to UTI pathogenesis. A growing body of evidence exists implicating genetic factors that can contribute to UTI risks. In this review, we highlight genetic variations in aspects of the innate immune system critical to the host response to uropathogens. This overview includes genetic variations in pattern recognition receptor molecules, chemokines/cytokines, and neutrophil activation. We also comprehensively cover murine knockout models of UTI, genetic variations involved in renal scarring as a result of ascending UTIs, and asymptomatic bacteriuria.... (More)

The urinary tract is a sterile organ system. Urinary tract infections (UTIs) are common and often serious infections. Research has focused on uropathogen, environment, and host factors leading to UTI pathogenesis. A growing body of evidence exists implicating genetic factors that can contribute to UTI risks. In this review, we highlight genetic variations in aspects of the innate immune system critical to the host response to uropathogens. This overview includes genetic variations in pattern recognition receptor molecules, chemokines/cytokines, and neutrophil activation. We also comprehensively cover murine knockout models of UTI, genetic variations involved in renal scarring as a result of ascending UTIs, and asymptomatic bacteriuria.

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Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Journal Article, Review
in
Journal of pediatric genetics
volume
5
issue
1
pages
25 - 32
publisher
Georg Thieme Verlag
external identifiers
  • pmid:27617139
ISSN
2146-4596
DOI
10.1055/s-0035-1557110
language
English
LU publication?
yes
id
6aacfe2a-07dc-451c-a891-7706356d2723
date added to LUP
2018-05-17 17:00:28
date last changed
2018-11-21 21:39:53
@article{6aacfe2a-07dc-451c-a891-7706356d2723,
  abstract     = {{<p>The urinary tract is a sterile organ system. Urinary tract infections (UTIs) are common and often serious infections. Research has focused on uropathogen, environment, and host factors leading to UTI pathogenesis. A growing body of evidence exists implicating genetic factors that can contribute to UTI risks. In this review, we highlight genetic variations in aspects of the innate immune system critical to the host response to uropathogens. This overview includes genetic variations in pattern recognition receptor molecules, chemokines/cytokines, and neutrophil activation. We also comprehensively cover murine knockout models of UTI, genetic variations involved in renal scarring as a result of ascending UTIs, and asymptomatic bacteriuria. </p>}},
  author       = {{Ambite, Ines and RYDSTRÖM, GUSTAV and Schwaderer, Andrew L and Hains, David S}},
  issn         = {{2146-4596}},
  keywords     = {{Journal Article; Review}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{25--32}},
  publisher    = {{Georg Thieme Verlag}},
  series       = {{Journal of pediatric genetics}},
  title        = {{The Genetics of Urinary Tract Infections and the Innate Defense of the Kidney and Urinary tract}},
  url          = {{http://dx.doi.org/10.1055/s-0035-1557110}},
  doi          = {{10.1055/s-0035-1557110}},
  volume       = {{5}},
  year         = {{2016}},
}