Load and lock: the molecular mechanisms of B-lymphocyte commitment.
(2010) In Immunological Reviews 238(1). p.47-62- Abstract
- Summary: The maturation of B-lymphoid cells from hematopoietic stem cells in the bone marrow is a complex process under control of interplay between extrinsic and intrinsic factors. In addition to serving as a model for normal cell differentiation, disturbances in this process results in immunodeficiencies and malignancies, such as leukemia and lymphoma, making the subject of high relevance for modern medicine. Although the process of B lymphopoiesis has been under intense investigation, recent methodological developments within the area of cell sorting, genome-wide expression, and DNA-binding analysis has allowed for a rapid development of the understanding of B-lymphocyte differentiation. This has suggested that the path to B-lymphoid... (More)
- Summary: The maturation of B-lymphoid cells from hematopoietic stem cells in the bone marrow is a complex process under control of interplay between extrinsic and intrinsic factors. In addition to serving as a model for normal cell differentiation, disturbances in this process results in immunodeficiencies and malignancies, such as leukemia and lymphoma, making the subject of high relevance for modern medicine. Although the process of B lymphopoiesis has been under intense investigation, recent methodological developments within the area of cell sorting, genome-wide expression, and DNA-binding analysis has allowed for a rapid development of the understanding of B-lymphocyte differentiation. This has suggested that the path to B-lymphoid cell fate may be initiated by lineage priming reflected in the expression of lymphoid associated genes already in multipotent hematopoietic progenitors. Upon differentiation, the gene expression profile is changed to involve an increasing number of B-lineage-restricted genes linked to loss of alternative developmental potentials and B-lineage commitment. This review focuses on the molecular regulation of early B-lymphoid development and aims to provide an up to date summary of the current status of the research area. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1710857
- author
- Zandi, Sasan ; Bryder, David LU and Sigvardsson, Mikael LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Immunological Reviews
- volume
- 238
- issue
- 1
- pages
- 47 - 62
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000283509100005
- pmid:20969584
- scopus:77958542905
- ISSN
- 1600-065X
- DOI
- 10.1111/j.1600-065X.2010.00950.x
- language
- English
- LU publication?
- yes
- id
- 6ad726b3-5e59-43cf-87a7-4f11c5c8ec89 (old id 1710857)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/20969584?dopt=Abstract
- date added to LUP
- 2016-04-04 09:06:48
- date last changed
- 2022-02-28 06:26:53
@article{6ad726b3-5e59-43cf-87a7-4f11c5c8ec89,
abstract = {{Summary: The maturation of B-lymphoid cells from hematopoietic stem cells in the bone marrow is a complex process under control of interplay between extrinsic and intrinsic factors. In addition to serving as a model for normal cell differentiation, disturbances in this process results in immunodeficiencies and malignancies, such as leukemia and lymphoma, making the subject of high relevance for modern medicine. Although the process of B lymphopoiesis has been under intense investigation, recent methodological developments within the area of cell sorting, genome-wide expression, and DNA-binding analysis has allowed for a rapid development of the understanding of B-lymphocyte differentiation. This has suggested that the path to B-lymphoid cell fate may be initiated by lineage priming reflected in the expression of lymphoid associated genes already in multipotent hematopoietic progenitors. Upon differentiation, the gene expression profile is changed to involve an increasing number of B-lineage-restricted genes linked to loss of alternative developmental potentials and B-lineage commitment. This review focuses on the molecular regulation of early B-lymphoid development and aims to provide an up to date summary of the current status of the research area.}},
author = {{Zandi, Sasan and Bryder, David and Sigvardsson, Mikael}},
issn = {{1600-065X}},
language = {{eng}},
number = {{1}},
pages = {{47--62}},
publisher = {{Wiley-Blackwell}},
series = {{Immunological Reviews}},
title = {{Load and lock: the molecular mechanisms of B-lymphocyte commitment.}},
url = {{http://dx.doi.org/10.1111/j.1600-065X.2010.00950.x}},
doi = {{10.1111/j.1600-065X.2010.00950.x}},
volume = {{238}},
year = {{2010}},
}