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SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis

Appendino, G ; Prosperini, S ; Valdivia, Carola LU ; Ballero, M ; Colombano, G ; Billington, R A ; Genazzani, A A and Sterner, Olov LU (2005) In Journal of Natural Products 68(8). p.1213-1217
Abstract
An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.
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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Natural Products
volume
68
issue
8
pages
1213 - 1217
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:16124763
  • wos:000231578000014
  • scopus:24744471405
ISSN
0163-3864
DOI
10.1021/np050115m
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
id
6ae10736-4a0d-44fa-926b-2eac5489e690 (old id 152347)
date added to LUP
2016-04-01 16:40:56
date last changed
2022-03-22 20:25:22
@article{6ae10736-4a0d-44fa-926b-2eac5489e690,
  abstract     = {{An investigation of Thapsia garganica afforded a series of tetracyclic C-19 dilactones, whose production was dependent on the time and location of the collection. These unusual tetrahomosesquiterpenoids are presumably biosynthesized via a carbon dioxide-triggered electrophilic polyolefin cyclization. Despite the structural differences with thapsigargin, these compounds showed SERCA-inhibiting properties.}},
  author       = {{Appendino, G and Prosperini, S and Valdivia, Carola and Ballero, M and Colombano, G and Billington, R A and Genazzani, A A and Sterner, Olov}},
  issn         = {{0163-3864}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{1213--1217}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Journal of Natural Products}},
  title        = {{SERCA-inhibiting activity of C-19 terpenolides from Thapsia garganica and their possible biogenesis}},
  url          = {{http://dx.doi.org/10.1021/np050115m}},
  doi          = {{10.1021/np050115m}},
  volume       = {{68}},
  year         = {{2005}},
}