Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Changes in breast density over serial mammograms : A case-control study

Sartor, Hanna LU ; Kontos, Despina ; Ullén, Susann LU ; Förnvik, Hannie LU and Förnvik, Daniel LU (2020) In European Journal of Radiology 127.
Abstract

Purpose: In addition to a breast density category, temporal changes in breast density have gained attention as a dynamic breast cancer risk marker. This case-control study aimed to investigate a potential change in breast density preceding tumor development and the relationship of this potential change to prognostic pathological tumor variables. Method: A total of 51 consecutive, eligible-for-analyses, biopsy-proven breast cancers were diagnosed between 1 st of August and 31 st of December 2014 at Skåne University Hospital, Sweden. Mammogram data and patient- and tumor characteristics were retrieved retrospectively from medical charts. Breast density was quantitatively estimated using LIBRA (a free open source software package). The... (More)

Purpose: In addition to a breast density category, temporal changes in breast density have gained attention as a dynamic breast cancer risk marker. This case-control study aimed to investigate a potential change in breast density preceding tumor development and the relationship of this potential change to prognostic pathological tumor variables. Method: A total of 51 consecutive, eligible-for-analyses, biopsy-proven breast cancers were diagnosed between 1 st of August and 31 st of December 2014 at Skåne University Hospital, Sweden. Mammogram data and patient- and tumor characteristics were retrieved retrospectively from medical charts. Breast density was quantitatively estimated using LIBRA (a free open source software package). The cases were matched for year of birth, number of screening rounds, and date for first and last mammograms with controls from the Malmö Breast Tomosynthesis Screening Trial in a 1:2 ratio, resulting in median time between mammograms of 4.5 (1.3–11.9) years for cases and 4.7 (1.4–11.1) years for controls, averaging approximately three screening rounds (1–6 rounds). Results: We detected a statistically significant difference in breast density change over time, with cases showing an increase in breast density (1.7 %) as compared to controls (-0.3 %) (p = 0.045). We found that in women with breast cancer, older women (≥ 55 years) experienced a higher breast density increase compared to younger women (5.1 % vs. 0.3 %, p = 0.002). Conclusions: There was a statistically significant difference in density change, where women with breast cancer showed an increased density over time, which was particularly evident in women > 55 years of age.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Breast cancer, Breast density, Mammography
in
European Journal of Radiology
volume
127
article number
108980
publisher
Elsevier
external identifiers
  • scopus:85083296931
  • pmid:32320912
ISSN
0720-048X
DOI
10.1016/j.ejrad.2020.108980
language
English
LU publication?
yes
id
6ae36b0a-530e-4387-8c52-6b54b8baef63
date added to LUP
2020-04-28 13:44:25
date last changed
2024-05-29 13:02:16
@article{6ae36b0a-530e-4387-8c52-6b54b8baef63,
  abstract     = {{<p>Purpose: In addition to a breast density category, temporal changes in breast density have gained attention as a dynamic breast cancer risk marker. This case-control study aimed to investigate a potential change in breast density preceding tumor development and the relationship of this potential change to prognostic pathological tumor variables. Method: A total of 51 consecutive, eligible-for-analyses, biopsy-proven breast cancers were diagnosed between 1 st of August and 31 st of December 2014 at Skåne University Hospital, Sweden. Mammogram data and patient- and tumor characteristics were retrieved retrospectively from medical charts. Breast density was quantitatively estimated using LIBRA (a free open source software package). The cases were matched for year of birth, number of screening rounds, and date for first and last mammograms with controls from the Malmö Breast Tomosynthesis Screening Trial in a 1:2 ratio, resulting in median time between mammograms of 4.5 (1.3–11.9) years for cases and 4.7 (1.4–11.1) years for controls, averaging approximately three screening rounds (1–6 rounds). Results: We detected a statistically significant difference in breast density change over time, with cases showing an increase in breast density (1.7 %) as compared to controls (-0.3 %) (p = 0.045). We found that in women with breast cancer, older women (≥ 55 years) experienced a higher breast density increase compared to younger women (5.1 % vs. 0.3 %, p = 0.002). Conclusions: There was a statistically significant difference in density change, where women with breast cancer showed an increased density over time, which was particularly evident in women &gt; 55 years of age.</p>}},
  author       = {{Sartor, Hanna and Kontos, Despina and Ullén, Susann and Förnvik, Hannie and Förnvik, Daniel}},
  issn         = {{0720-048X}},
  keywords     = {{Breast cancer; Breast density; Mammography}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Radiology}},
  title        = {{Changes in breast density over serial mammograms : A case-control study}},
  url          = {{http://dx.doi.org/10.1016/j.ejrad.2020.108980}},
  doi          = {{10.1016/j.ejrad.2020.108980}},
  volume       = {{127}},
  year         = {{2020}},
}