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Circumferential resection margin and local recurrence after rectal cancer surgery: a population-based study cohort

Agger, Erik LU orcid ; Jörgren, Fredrik LU ; Lydrup, Marie-Louise LU and Buchwald, Pamela LU (2019) European Society of Coloproctology In Colorectal Disease 21(S3). p.22-22
Abstract
Aim: Studies have suggested that there is a difference in risk of local recurrence(LR) with circumferential resection margins (CRM) less than 1.0 mm. We aimed toexamine how exact resection margins affect LR risk.
Method: Data from the Swedish Colorectal Cancer Registry (SCRCR) were usedfor retrospective analysis of resected rectal cancers between 2005 and 2013. Primaryendpoint was LR.
Results: 12146 cases were identified of which 8666 cases were analysed after exclusion. 388 cases had CRM < 1.0 mm and 8278 cases CRM ≥ 1.0 mm. There were 42LR (11.4%) when CRM < 1.0 mm and 280 LR (3.5%) when CRM ≥ 1.0 mm. LRrate was 17% (n = 27/159), 7.1% (n = 15/210), 5.5% (n = 26/473) and 3.4%(n = 254/7550) when CRM was 0.0 mm, 0.1–0.9 mm,... (More)
Aim: Studies have suggested that there is a difference in risk of local recurrence(LR) with circumferential resection margins (CRM) less than 1.0 mm. We aimed toexamine how exact resection margins affect LR risk.
Method: Data from the Swedish Colorectal Cancer Registry (SCRCR) were usedfor retrospective analysis of resected rectal cancers between 2005 and 2013. Primaryendpoint was LR.
Results: 12146 cases were identified of which 8666 cases were analysed after exclusion. 388 cases had CRM < 1.0 mm and 8278 cases CRM ≥ 1.0 mm. There were 42LR (11.4%) when CRM < 1.0 mm and 280 LR (3.5%) when CRM ≥ 1.0 mm. LRrate was 17% (n = 27/159), 7.1% (n = 15/210), 5.5% (n = 26/473) and 3.4%(n = 254/7550) when CRM was 0.0 mm, 0.1–0.9 mm, 1.0–1.9 mm andCRM ≥ 2 mm respectively. LR risk at CRM 0.0 mm was significantly increased compared to all other groups. No significant difference in LR between CRM 1.0–1.9 mm and ≥ 2 mm was observed. LR was diagnosed earlier when CRM < 1.0 mm.
Conclusion: LR risk is related with accuracy to the surgical circumferential resec-tion margin distance. There was no difference in LR risk above CRM 1.0 mm.Most LRs occurred within two years after surgery when CRM was below 1.0 mm (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Colorectal Disease
volume
21
issue
S3
article number
WP19
pages
22 - 22
publisher
Wiley-Blackwell
conference name
European Society of Coloproctology
conference location
Wien, Austria
conference dates
2019-09-25 - 2019-09-27
ISSN
1462-8910
DOI
10.1111/codi.14774
language
English
LU publication?
yes
id
6aeb6fc1-83d8-456b-920a-76a9fb6f02f8
date added to LUP
2021-11-06 09:08:22
date last changed
2021-11-08 09:23:32
@misc{6aeb6fc1-83d8-456b-920a-76a9fb6f02f8,
  abstract     = {{Aim: Studies have suggested that there is a difference in risk of local recurrence(LR) with circumferential resection margins (CRM) less than 1.0 mm. We aimed toexamine how exact resection margins affect LR risk.<br/>Method: Data from the Swedish Colorectal Cancer Registry (SCRCR) were usedfor retrospective analysis of resected rectal cancers between 2005 and 2013. Primaryendpoint was LR.<br/>Results: 12146 cases were identified of which 8666 cases were analysed after exclusion. 388 cases had CRM &lt; 1.0 mm and 8278 cases CRM ≥ 1.0 mm. There were 42LR (11.4%) when CRM &lt; 1.0 mm and 280 LR (3.5%) when CRM ≥ 1.0 mm. LRrate was 17% (n = 27/159), 7.1% (n = 15/210), 5.5% (n = 26/473) and 3.4%(n = 254/7550) when CRM was 0.0 mm, 0.1–0.9 mm, 1.0–1.9 mm andCRM ≥ 2 mm respectively. LR risk at CRM 0.0 mm was significantly increased compared to all other groups. No significant difference in LR between CRM 1.0–1.9 mm and ≥ 2 mm was observed. LR was diagnosed earlier when CRM &lt; 1.0 mm.<br/>Conclusion: LR risk is related with accuracy to the surgical circumferential resec-tion margin distance. There was no difference in LR risk above CRM 1.0 mm.Most LRs occurred within two years after surgery when CRM was below 1.0 mm}},
  author       = {{Agger, Erik and Jörgren, Fredrik and Lydrup, Marie-Louise and Buchwald, Pamela}},
  issn         = {{1462-8910}},
  language     = {{eng}},
  note         = {{Conference Abstract}},
  number       = {{S3}},
  pages        = {{22--22}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Colorectal Disease}},
  title        = {{Circumferential resection margin and local recurrence after rectal cancer surgery: a population-based study cohort}},
  url          = {{http://dx.doi.org/10.1111/codi.14774}},
  doi          = {{10.1111/codi.14774}},
  volume       = {{21}},
  year         = {{2019}},
}