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Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population : ABIS study

Milletich, Patricia L. ; Ahrens, Angelica P. ; Russell, Jordan T. ; Petrone, Joseph R. ; Berryman, Meghan A. ; Agardh, Daniel LU ; Ludvigsson, Jonas F. ; Triplett, Eric W. and Ludvigsson, Johnny (2022) In Frontiers in cellular and infection microbiology 12.
Abstract

Although gut microbiome dysbiosis has been illustrated in celiac disease (CD), there are disagreements about what constitutes these microbial signatures and the timeline by which they precede diagnosis is largely unknown. The study of high-genetic-risk patients or those already with CD limits our knowledge of dysbiosis that may occur early in life in a generalized population. To explore early gut microbial imbalances correlated with future celiac disease (fCD), we analyzed the stool of 1478 infants aged one year, 26 of whom later acquired CD, with a mean age of diagnosis of 10.96 ± 5.6 years. With a novel iterative control-matching algorithm using the prospective general population cohort, All Babies In Southeast Sweden, we found nine... (More)

Although gut microbiome dysbiosis has been illustrated in celiac disease (CD), there are disagreements about what constitutes these microbial signatures and the timeline by which they precede diagnosis is largely unknown. The study of high-genetic-risk patients or those already with CD limits our knowledge of dysbiosis that may occur early in life in a generalized population. To explore early gut microbial imbalances correlated with future celiac disease (fCD), we analyzed the stool of 1478 infants aged one year, 26 of whom later acquired CD, with a mean age of diagnosis of 10.96 ± 5.6 years. With a novel iterative control-matching algorithm using the prospective general population cohort, All Babies In Southeast Sweden, we found nine core microbes with prevalence differences and seven differentially abundant bacteria between fCD infants and controls. The differences were validated using 100 separate, iterative permutations of matched controls, which suggests the bacterial signatures are significant in fCD even when accounting for the inherent variability in a general population. This work is the first to our knowledge to demonstrate that gut microbial differences in prevalence and abundance exist in infants aged one year up to 19 years before a diagnosis of CD in a general population.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
autoimmunity, celiac disease, gut microbiome, human leucocyte antigen, infant
in
Frontiers in cellular and infection microbiology
volume
12
article number
920735
publisher
Frontiers Media S. A.
external identifiers
  • scopus:85136340295
  • pmid:35959362
ISSN
2235-2988
DOI
10.3389/fcimb.2022.920735
language
English
LU publication?
yes
additional info
Publisher Copyright: Copyright © 2022 Milletich, Ahrens, Russell, Petrone, Berryman, Agardh, Ludvigsson, Triplett and Ludvigsson.
id
6b4afdbd-0689-4c64-b459-c9699f4402b5
date added to LUP
2022-10-07 13:45:29
date last changed
2024-06-13 20:01:28
@article{6b4afdbd-0689-4c64-b459-c9699f4402b5,
  abstract     = {{<p>Although gut microbiome dysbiosis has been illustrated in celiac disease (CD), there are disagreements about what constitutes these microbial signatures and the timeline by which they precede diagnosis is largely unknown. The study of high-genetic-risk patients or those already with CD limits our knowledge of dysbiosis that may occur early in life in a generalized population. To explore early gut microbial imbalances correlated with future celiac disease (fCD), we analyzed the stool of 1478 infants aged one year, 26 of whom later acquired CD, with a mean age of diagnosis of 10.96 ± 5.6 years. With a novel iterative control-matching algorithm using the prospective general population cohort, All Babies In Southeast Sweden, we found nine core microbes with prevalence differences and seven differentially abundant bacteria between fCD infants and controls. The differences were validated using 100 separate, iterative permutations of matched controls, which suggests the bacterial signatures are significant in fCD even when accounting for the inherent variability in a general population. This work is the first to our knowledge to demonstrate that gut microbial differences in prevalence and abundance exist in infants aged one year up to 19 years before a diagnosis of CD in a general population.</p>}},
  author       = {{Milletich, Patricia L. and Ahrens, Angelica P. and Russell, Jordan T. and Petrone, Joseph R. and Berryman, Meghan A. and Agardh, Daniel and Ludvigsson, Jonas F. and Triplett, Eric W. and Ludvigsson, Johnny}},
  issn         = {{2235-2988}},
  keywords     = {{autoimmunity; celiac disease; gut microbiome; human leucocyte antigen; infant}},
  language     = {{eng}},
  publisher    = {{Frontiers Media S. A.}},
  series       = {{Frontiers in cellular and infection microbiology}},
  title        = {{Gut microbiome markers in subgroups of HLA class II genotyped infants signal future celiac disease in the general population : ABIS study}},
  url          = {{http://dx.doi.org/10.3389/fcimb.2022.920735}},
  doi          = {{10.3389/fcimb.2022.920735}},
  volume       = {{12}},
  year         = {{2022}},
}