Development of a novel combined fluorescence and reflectance spectroscopy system for guiding high-grade glioma resections _ Confirmation of capability in lab experiments
(2013) 1st International Conference on Biophotonics-Riga 9032. p.90320-90320- Abstract
- Total resection of glioblastoma multiform (GBM), the most common and aggressive malignant brain tumor, is challenging among other things due to difficulty in intraoperative discrimination between normal and residual tumor cells. This project demonstrates the potential of a system based on a combination of autofluorescence and diffuse reflectance spectroscopy to be useful as an intraoperative guiding tool. In this context, a system based on 5 LEDs coupled to optical fibers was employed to deliver UV/visible light to the sample sequentially. Remitted light from the tissue; including diffuse reflected and fluorescence of endogenous and exogenous fluorophores, as well as its photobleaching product, is transmitted to one photodiode and four... (More)
- Total resection of glioblastoma multiform (GBM), the most common and aggressive malignant brain tumor, is challenging among other things due to difficulty in intraoperative discrimination between normal and residual tumor cells. This project demonstrates the potential of a system based on a combination of autofluorescence and diffuse reflectance spectroscopy to be useful as an intraoperative guiding tool. In this context, a system based on 5 LEDs coupled to optical fibers was employed to deliver UV/visible light to the sample sequentially. Remitted light from the tissue; including diffuse reflected and fluorescence of endogenous and exogenous fluorophores, as well as its photobleaching product, is transmitted to one photodiode and four avalanche photodiodes. This instrument has been evaluated with very promising results by performing various tissue-equivalent phantom laboratory and clinical studies on skin lesions. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4272176
- author
- Mousavi, Monirehalsadat LU ; Xie, Haiyan LU ; Xie, Zhiyuan ; Brydegaard, Mikkel LU ; Axelsson, Johan LU and Andersson-Engels, Stefan LU
- organization
- publishing date
- 2013
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Biophotonics—Riga 2013 (Proceedings of SPIE)
- volume
- 9032
- pages
- 90320 - 90320
- publisher
- SPIE
- conference name
- 1st International Conference on Biophotonics-Riga
- conference location
- Riga, Latvia
- conference dates
- 2013-08-26 - 2013-08-31
- external identifiers
-
- wos:000328606800022
- scopus:84891309690
- ISSN
- 1996-756X
- 0277-786X
- DOI
- 10.1117/12.2044480
- language
- English
- LU publication?
- yes
- id
- 6b52371f-e11e-4b98-a805-a55526fb3fbb (old id 4272176)
- date added to LUP
- 2016-04-01 10:13:04
- date last changed
- 2024-01-06 10:49:49
@inproceedings{6b52371f-e11e-4b98-a805-a55526fb3fbb,
abstract = {{Total resection of glioblastoma multiform (GBM), the most common and aggressive malignant brain tumor, is challenging among other things due to difficulty in intraoperative discrimination between normal and residual tumor cells. This project demonstrates the potential of a system based on a combination of autofluorescence and diffuse reflectance spectroscopy to be useful as an intraoperative guiding tool. In this context, a system based on 5 LEDs coupled to optical fibers was employed to deliver UV/visible light to the sample sequentially. Remitted light from the tissue; including diffuse reflected and fluorescence of endogenous and exogenous fluorophores, as well as its photobleaching product, is transmitted to one photodiode and four avalanche photodiodes. This instrument has been evaluated with very promising results by performing various tissue-equivalent phantom laboratory and clinical studies on skin lesions.}},
author = {{Mousavi, Monirehalsadat and Xie, Haiyan and Xie, Zhiyuan and Brydegaard, Mikkel and Axelsson, Johan and Andersson-Engels, Stefan}},
booktitle = {{Biophotonics—Riga 2013 (Proceedings of SPIE)}},
issn = {{1996-756X}},
language = {{eng}},
pages = {{90320--90320}},
publisher = {{SPIE}},
title = {{Development of a novel combined fluorescence and reflectance spectroscopy system for guiding high-grade glioma resections _ Confirmation of capability in lab experiments}},
url = {{http://dx.doi.org/10.1117/12.2044480}},
doi = {{10.1117/12.2044480}},
volume = {{9032}},
year = {{2013}},
}