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Development of a novel combined fluorescence and reflectance spectroscopy system for guiding high-grade glioma resections _ Confirmation of capability in lab experiments

Mousavi, Monirehalsadat LU ; Xie, Haiyan LU ; Xie, Zhiyuan; Brydegaard, Mikkel LU ; Axelsson, Johan LU and Andersson-Engels, Stefan LU (2013) 1st International Conference on Biophotonics-Riga 9032. p.90320-90320
Abstract
Total resection of glioblastoma multiform (GBM), the most common and aggressive malignant brain tumor, is challenging among other things due to difficulty in intraoperative discrimination between normal and residual tumor cells. This project demonstrates the potential of a system based on a combination of autofluorescence and diffuse reflectance spectroscopy to be useful as an intraoperative guiding tool. In this context, a system based on 5 LEDs coupled to optical fibers was employed to deliver UV/visible light to the sample sequentially. Remitted light from the tissue; including diffuse reflected and fluorescence of endogenous and exogenous fluorophores, as well as its photobleaching product, is transmitted to one photodiode and four... (More)
Total resection of glioblastoma multiform (GBM), the most common and aggressive malignant brain tumor, is challenging among other things due to difficulty in intraoperative discrimination between normal and residual tumor cells. This project demonstrates the potential of a system based on a combination of autofluorescence and diffuse reflectance spectroscopy to be useful as an intraoperative guiding tool. In this context, a system based on 5 LEDs coupled to optical fibers was employed to deliver UV/visible light to the sample sequentially. Remitted light from the tissue; including diffuse reflected and fluorescence of endogenous and exogenous fluorophores, as well as its photobleaching product, is transmitted to one photodiode and four avalanche photodiodes. This instrument has been evaluated with very promising results by performing various tissue-equivalent phantom laboratory and clinical studies on skin lesions. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Biophotonics—Riga 2013 (Proceedings of SPIE)
volume
9032
pages
90320 - 90320
publisher
SPIE
conference name
1st International Conference on Biophotonics-Riga
conference location
Riga, Latvia
conference dates
2013-08-26 - 2013-08-31
external identifiers
  • wos:000328606800022
  • scopus:84891309690
ISSN
1996-756X
0277-786X
DOI
10.1117/12.2044480
language
English
LU publication?
yes
id
6b52371f-e11e-4b98-a805-a55526fb3fbb (old id 4272176)
date added to LUP
2014-02-11 14:26:15
date last changed
2019-02-20 01:44:32
@inproceedings{6b52371f-e11e-4b98-a805-a55526fb3fbb,
  abstract     = {Total resection of glioblastoma multiform (GBM), the most common and aggressive malignant brain tumor, is challenging among other things due to difficulty in intraoperative discrimination between normal and residual tumor cells. This project demonstrates the potential of a system based on a combination of autofluorescence and diffuse reflectance spectroscopy to be useful as an intraoperative guiding tool. In this context, a system based on 5 LEDs coupled to optical fibers was employed to deliver UV/visible light to the sample sequentially. Remitted light from the tissue; including diffuse reflected and fluorescence of endogenous and exogenous fluorophores, as well as its photobleaching product, is transmitted to one photodiode and four avalanche photodiodes. This instrument has been evaluated with very promising results by performing various tissue-equivalent phantom laboratory and clinical studies on skin lesions.},
  author       = {Mousavi, Monirehalsadat and Xie, Haiyan and Xie, Zhiyuan and Brydegaard, Mikkel and Axelsson, Johan and Andersson-Engels, Stefan},
  issn         = {1996-756X},
  language     = {eng},
  location     = {Riga, Latvia},
  pages        = {90320--90320},
  publisher    = {SPIE},
  title        = {Development of a novel combined fluorescence and reflectance spectroscopy system for guiding high-grade glioma resections _ Confirmation of capability in lab experiments},
  url          = {http://dx.doi.org/10.1117/12.2044480},
  volume       = {9032},
  year         = {2013},
}