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Seasonal influenza vaccine effectiveness against influenza in 2012-2013 : A hospital-based case-control study in Lithuania

Gefenaite, Giedre LU ; Rahamat-Langendoen, Janette ; Ambrozaitis, Arvydas ; Mickiene, Aukse ; Jancoriene, Ligita ; Kuliese, Monika ; Velyvyte, Daiva ; Niesters, Hubert ; Stolk, Ronald P. and Zagminas, Kestutis , et al. (2014) In Vaccine 32(7). p.857-863
Abstract

Background: Due to scarce information on seasonal influenza vaccine effectiveness (SIVE) against severe clinical influenza outcomes in risk populations, we conducted a case-control study to assess its effects against laboratory-confirmed influenza in hospitalized patients during the 2012-2013 influenza season. Methods: We conducted a test-negative case-control study among ≥18 years old patients with influenza-like illness (ILI) hospitalized in two Lithuanian hospitals. Cases were influenza A(H1N1), A(H3) or influenza B positive by RT-PCR, and controls were influenza negative. Additional demographic and clinical data to assess the role of confounding were collected. SIVE and its confidence intervals (95% CI) were estimated by using... (More)

Background: Due to scarce information on seasonal influenza vaccine effectiveness (SIVE) against severe clinical influenza outcomes in risk populations, we conducted a case-control study to assess its effects against laboratory-confirmed influenza in hospitalized patients during the 2012-2013 influenza season. Methods: We conducted a test-negative case-control study among ≥18 years old patients with influenza-like illness (ILI) hospitalized in two Lithuanian hospitals. Cases were influenza A(H1N1), A(H3) or influenza B positive by RT-PCR, and controls were influenza negative. Additional demographic and clinical data to assess the role of confounding were collected. SIVE and its confidence intervals (95% CI) were estimated by using multivariate logistic regression as (1. OR). ×. 100%. Results: The sample consisted of 185 subjects. Seasonal influenza vaccine uptake was 5%. Among 111 (60%) influenza positive cases, 24.3% were A(H1N1), 10.8% were A(H3) and 24.3% were influenza B cases. Unadjusted SIVE was 79% (95% CI -6% to 96%) and after the adjustment it increased to 86% (95% CI 19% to 97%). Conclusions: Seasonal influenza vaccination in 2012-2013 was associated with reduced occurrence of laboratory-confirmed influenza, but due to low sample size the estimate of SIVE is imprecise. Given high prevalence of influenza in hospitalized ILI cases and low influenza vaccination coverage, there is a need to increase influenza vaccination rates.

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publishing date
type
Contribution to journal
publication status
published
subject
keywords
Case-control studies, Effectiveness, Influenza, Influenza vaccine, Lithuania
in
Vaccine
volume
32
issue
7
pages
857 - 863
publisher
Elsevier
external identifiers
  • scopus:84892857429
  • pmid:24370711
ISSN
0264-410X
DOI
10.1016/j.vaccine.2013.12.021
language
English
LU publication?
no
id
6b6de864-82bf-42da-bb00-c8c020486744
date added to LUP
2020-05-14 14:30:53
date last changed
2020-09-30 06:39:20
@article{6b6de864-82bf-42da-bb00-c8c020486744,
  abstract     = {<p>Background: Due to scarce information on seasonal influenza vaccine effectiveness (SIVE) against severe clinical influenza outcomes in risk populations, we conducted a case-control study to assess its effects against laboratory-confirmed influenza in hospitalized patients during the 2012-2013 influenza season. Methods: We conducted a test-negative case-control study among ≥18 years old patients with influenza-like illness (ILI) hospitalized in two Lithuanian hospitals. Cases were influenza A(H1N1), A(H3) or influenza B positive by RT-PCR, and controls were influenza negative. Additional demographic and clinical data to assess the role of confounding were collected. SIVE and its confidence intervals (95% CI) were estimated by using multivariate logistic regression as (1. OR). ×. 100%. Results: The sample consisted of 185 subjects. Seasonal influenza vaccine uptake was 5%. Among 111 (60%) influenza positive cases, 24.3% were A(H1N1), 10.8% were A(H3) and 24.3% were influenza B cases. Unadjusted SIVE was 79% (95% CI -6% to 96%) and after the adjustment it increased to 86% (95% CI 19% to 97%). Conclusions: Seasonal influenza vaccination in 2012-2013 was associated with reduced occurrence of laboratory-confirmed influenza, but due to low sample size the estimate of SIVE is imprecise. Given high prevalence of influenza in hospitalized ILI cases and low influenza vaccination coverage, there is a need to increase influenza vaccination rates.</p>},
  author       = {Gefenaite, Giedre and Rahamat-Langendoen, Janette and Ambrozaitis, Arvydas and Mickiene, Aukse and Jancoriene, Ligita and Kuliese, Monika and Velyvyte, Daiva and Niesters, Hubert and Stolk, Ronald P. and Zagminas, Kestutis and Hak, Eelko},
  issn         = {0264-410X},
  language     = {eng},
  month        = {02},
  number       = {7},
  pages        = {857--863},
  publisher    = {Elsevier},
  series       = {Vaccine},
  title        = {Seasonal influenza vaccine effectiveness against influenza in 2012-2013 : A hospital-based case-control study in Lithuania},
  url          = {http://dx.doi.org/10.1016/j.vaccine.2013.12.021},
  doi          = {10.1016/j.vaccine.2013.12.021},
  volume       = {32},
  year         = {2014},
}