The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury
(2022) In JACC: Basic to Translational Science 7(3P1). p.294-308- Abstract
The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be... (More)
The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.
(Less)
- author
- organization
- publishing date
- 2022-03
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- athlete, cardiovascular magnetic resonance imaging, COVID-19, inflammation, myocardial injury, myocarditis, sudden cardiac death, troponin
- in
- JACC: Basic to Translational Science
- volume
- 7
- issue
- 3P1
- pages
- 15 pages
- publisher
- Elsevier
- external identifiers
-
- scopus:85126450555
- pmid:35165665
- ISSN
- 2452-302X
- DOI
- 10.1016/j.jacbts.2021.10.011
- language
- English
- LU publication?
- yes
- id
- 6b7b0110-3ca4-46c5-a839-9a2ef80ff11a
- date added to LUP
- 2022-06-08 11:50:17
- date last changed
- 2024-09-20 22:19:16
@article{6b7b0110-3ca4-46c5-a839-9a2ef80ff11a, abstract = {{<p>The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.</p>}}, author = {{Siripanthong, Bhurint and Asatryan, Babken and Hanff, Thomas C. and Chatha, Salman R. and Khanji, Mohammed Y. and Ricci, Fabrizio and Muser, Daniele and Ferrari, Victor A. and Nazarian, Saman and Santangeli, Pasquale and Deo, Rajat and Cooper, Leslie T. and Mohiddin, Saidi A. and Chahal, C. Anwar A.}}, issn = {{2452-302X}}, keywords = {{athlete; cardiovascular magnetic resonance imaging; COVID-19; inflammation; myocardial injury; myocarditis; sudden cardiac death; troponin}}, language = {{eng}}, number = {{3P1}}, pages = {{294--308}}, publisher = {{Elsevier}}, series = {{JACC: Basic to Translational Science}}, title = {{The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury}}, url = {{http://dx.doi.org/10.1016/j.jacbts.2021.10.011}}, doi = {{10.1016/j.jacbts.2021.10.011}}, volume = {{7}}, year = {{2022}}, }