Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury

Siripanthong, Bhurint ; Asatryan, Babken ; Hanff, Thomas C. ; Chatha, Salman R. ; Khanji, Mohammed Y. ; Ricci, Fabrizio LU ; Muser, Daniele ; Ferrari, Victor A. ; Nazarian, Saman and Santangeli, Pasquale , et al. (2022) In JACC: Basic to Translational Science 7(3P1). p.294-308
Abstract

The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be... (More)

The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
athlete, cardiovascular magnetic resonance imaging, COVID-19, inflammation, myocardial injury, myocarditis, sudden cardiac death, troponin
in
JACC: Basic to Translational Science
volume
7
issue
3P1
pages
15 pages
publisher
Elsevier
external identifiers
  • scopus:85126450555
  • pmid:35165665
ISSN
2452-302X
DOI
10.1016/j.jacbts.2021.10.011
language
English
LU publication?
yes
id
6b7b0110-3ca4-46c5-a839-9a2ef80ff11a
date added to LUP
2022-06-08 11:50:17
date last changed
2024-06-13 13:44:24
@article{6b7b0110-3ca4-46c5-a839-9a2ef80ff11a,
  abstract     = {{<p>The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity.</p>}},
  author       = {{Siripanthong, Bhurint and Asatryan, Babken and Hanff, Thomas C. and Chatha, Salman R. and Khanji, Mohammed Y. and Ricci, Fabrizio and Muser, Daniele and Ferrari, Victor A. and Nazarian, Saman and Santangeli, Pasquale and Deo, Rajat and Cooper, Leslie T. and Mohiddin, Saidi A. and Chahal, C. Anwar A.}},
  issn         = {{2452-302X}},
  keywords     = {{athlete; cardiovascular magnetic resonance imaging; COVID-19; inflammation; myocardial injury; myocarditis; sudden cardiac death; troponin}},
  language     = {{eng}},
  number       = {{3P1}},
  pages        = {{294--308}},
  publisher    = {{Elsevier}},
  series       = {{JACC: Basic to Translational Science}},
  title        = {{The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury}},
  url          = {{http://dx.doi.org/10.1016/j.jacbts.2021.10.011}},
  doi          = {{10.1016/j.jacbts.2021.10.011}},
  volume       = {{7}},
  year         = {{2022}},
}