Plasma concentrations of persistent organochlorines in relation to thyrotropin and thyroid hormone levels in women
(2001) In International Archives of Occupational and Environmental Health 74(3). p.8-184- Abstract
OBJECTIVES: There is a concern that persistent organohalogen toxicants, such as polychlorinated biphenyls (PCBs), might display endocrine-disrupting effects in exposed populations. In this study the correlations between PCBs and thyrotropin (TSH) and thyroid hormone concentrations in plasma were assessed in adult women.
METHODS: The study group consisted of 182 fishermen's wives from the Swedish east coast, with a median age of 42 years (range 23-62) and a median current consumption of contaminated fatty fish from the Baltic Sea of two meals per month (range 0-12). TSH, free (FT3) and total (TT3) triiodothyronine and free (FT4) and total (TT4) thyroxin in plasma were analyzed by immunofluorometric assays, and... (More)
OBJECTIVES: There is a concern that persistent organohalogen toxicants, such as polychlorinated biphenyls (PCBs), might display endocrine-disrupting effects in exposed populations. In this study the correlations between PCBs and thyrotropin (TSH) and thyroid hormone concentrations in plasma were assessed in adult women.
METHODS: The study group consisted of 182 fishermen's wives from the Swedish east coast, with a median age of 42 years (range 23-62) and a median current consumption of contaminated fatty fish from the Baltic Sea of two meals per month (range 0-12). TSH, free (FT3) and total (TT3) triiodothyronine and free (FT4) and total (TT4) thyroxin in plasma were analyzed by immunofluorometric assays, and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) in plasma was analyzed by gas chromatography with electron capture detection. Twenty other PCB and two hydroxy-PCB congeners were analyzed in subgroups of the women. Plasma lipid analyses were performed with enzymatic techniques.
RESULTS: The CB-153 concentration in plasma (range 16-776 ng/g lipid) was negatively correlated with the TT3 concentrations (range 1.0-3.0 nmol/l, rs = -0.29, P < 0.001). This association remained after age adjustment.
CONCLUSIONS: The present study gives some support for the notion that dietary exposure to persistent organochlorine compounds (POCs) might weakly affect peripheral thyroid hormone concentrations in adult women.
(Less)
- author
- Hagmar, L
LU
; Rylander, L
LU
; Dyremark, E ; Klasson-Wehler, E and Erfurth, E M LU
- organization
- publishing date
- 2001-04
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Adult, Animals, Feeding Behavior, Female, Fishes, Fluoroimmunoassay, Food Contamination, Humans, Linear Models, Lipids/blood, Middle Aged, Polychlorinated Biphenyls/blood, Sweden/epidemiology, Thyroid Hormones/blood, Thyrotropin/blood
- in
- International Archives of Occupational and Environmental Health
- volume
- 74
- issue
- 3
- pages
- 8 - 184
- publisher
- Springer
- external identifiers
-
- scopus:0035039570
- pmid:11355292
- ISSN
- 0340-0131
- DOI
- 10.1007/s004200000213
- language
- English
- LU publication?
- yes
- id
- 6baa405f-534c-4eee-8e47-2af7ef6f7ff4
- date added to LUP
- 2023-11-20 08:55:33
- date last changed
- 2025-01-11 10:17:27
@article{6baa405f-534c-4eee-8e47-2af7ef6f7ff4, abstract = {{<p>OBJECTIVES: There is a concern that persistent organohalogen toxicants, such as polychlorinated biphenyls (PCBs), might display endocrine-disrupting effects in exposed populations. In this study the correlations between PCBs and thyrotropin (TSH) and thyroid hormone concentrations in plasma were assessed in adult women.</p><p>METHODS: The study group consisted of 182 fishermen's wives from the Swedish east coast, with a median age of 42 years (range 23-62) and a median current consumption of contaminated fatty fish from the Baltic Sea of two meals per month (range 0-12). TSH, free (FT3) and total (TT3) triiodothyronine and free (FT4) and total (TT4) thyroxin in plasma were analyzed by immunofluorometric assays, and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) in plasma was analyzed by gas chromatography with electron capture detection. Twenty other PCB and two hydroxy-PCB congeners were analyzed in subgroups of the women. Plasma lipid analyses were performed with enzymatic techniques.</p><p>RESULTS: The CB-153 concentration in plasma (range 16-776 ng/g lipid) was negatively correlated with the TT3 concentrations (range 1.0-3.0 nmol/l, rs = -0.29, P < 0.001). This association remained after age adjustment.</p><p>CONCLUSIONS: The present study gives some support for the notion that dietary exposure to persistent organochlorine compounds (POCs) might weakly affect peripheral thyroid hormone concentrations in adult women.</p>}}, author = {{Hagmar, L and Rylander, L and Dyremark, E and Klasson-Wehler, E and Erfurth, E M}}, issn = {{0340-0131}}, keywords = {{Adult; Animals; Feeding Behavior; Female; Fishes; Fluoroimmunoassay; Food Contamination; Humans; Linear Models; Lipids/blood; Middle Aged; Polychlorinated Biphenyls/blood; Sweden/epidemiology; Thyroid Hormones/blood; Thyrotropin/blood}}, language = {{eng}}, number = {{3}}, pages = {{8--184}}, publisher = {{Springer}}, series = {{International Archives of Occupational and Environmental Health}}, title = {{Plasma concentrations of persistent organochlorines in relation to thyrotropin and thyroid hormone levels in women}}, url = {{http://dx.doi.org/10.1007/s004200000213}}, doi = {{10.1007/s004200000213}}, volume = {{74}}, year = {{2001}}, }