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Plasma concentrations of persistent organochlorines in relation to thyrotropin and thyroid hormone levels in women

Hagmar, L LU ; Rylander, L LU orcid ; Dyremark, E ; Klasson-Wehler, E and Erfurth, E M LU (2001) In International Archives of Occupational and Environmental Health 74(3). p.8-184
Abstract

OBJECTIVES: There is a concern that persistent organohalogen toxicants, such as polychlorinated biphenyls (PCBs), might display endocrine-disrupting effects in exposed populations. In this study the correlations between PCBs and thyrotropin (TSH) and thyroid hormone concentrations in plasma were assessed in adult women.

METHODS: The study group consisted of 182 fishermen's wives from the Swedish east coast, with a median age of 42 years (range 23-62) and a median current consumption of contaminated fatty fish from the Baltic Sea of two meals per month (range 0-12). TSH, free (FT3) and total (TT3) triiodothyronine and free (FT4) and total (TT4) thyroxin in plasma were analyzed by immunofluorometric assays, and... (More)

OBJECTIVES: There is a concern that persistent organohalogen toxicants, such as polychlorinated biphenyls (PCBs), might display endocrine-disrupting effects in exposed populations. In this study the correlations between PCBs and thyrotropin (TSH) and thyroid hormone concentrations in plasma were assessed in adult women.

METHODS: The study group consisted of 182 fishermen's wives from the Swedish east coast, with a median age of 42 years (range 23-62) and a median current consumption of contaminated fatty fish from the Baltic Sea of two meals per month (range 0-12). TSH, free (FT3) and total (TT3) triiodothyronine and free (FT4) and total (TT4) thyroxin in plasma were analyzed by immunofluorometric assays, and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) in plasma was analyzed by gas chromatography with electron capture detection. Twenty other PCB and two hydroxy-PCB congeners were analyzed in subgroups of the women. Plasma lipid analyses were performed with enzymatic techniques.

RESULTS: The CB-153 concentration in plasma (range 16-776 ng/g lipid) was negatively correlated with the TT3 concentrations (range 1.0-3.0 nmol/l, rs = -0.29, P < 0.001). This association remained after age adjustment.

CONCLUSIONS: The present study gives some support for the notion that dietary exposure to persistent organochlorine compounds (POCs) might weakly affect peripheral thyroid hormone concentrations in adult women.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Animals, Feeding Behavior, Female, Fishes, Fluoroimmunoassay, Food Contamination, Humans, Linear Models, Lipids/blood, Middle Aged, Polychlorinated Biphenyls/blood, Sweden/epidemiology, Thyroid Hormones/blood, Thyrotropin/blood
in
International Archives of Occupational and Environmental Health
volume
74
issue
3
pages
8 - 184
publisher
Springer
external identifiers
  • scopus:0035039570
  • pmid:11355292
ISSN
0340-0131
DOI
10.1007/s004200000213
language
English
LU publication?
yes
id
6baa405f-534c-4eee-8e47-2af7ef6f7ff4
date added to LUP
2023-11-20 08:55:33
date last changed
2024-03-21 06:43:12
@article{6baa405f-534c-4eee-8e47-2af7ef6f7ff4,
  abstract     = {{<p>OBJECTIVES: There is a concern that persistent organohalogen toxicants, such as polychlorinated biphenyls (PCBs), might display endocrine-disrupting effects in exposed populations. In this study the correlations between PCBs and thyrotropin (TSH) and thyroid hormone concentrations in plasma were assessed in adult women.</p><p>METHODS: The study group consisted of 182 fishermen's wives from the Swedish east coast, with a median age of 42 years (range 23-62) and a median current consumption of contaminated fatty fish from the Baltic Sea of two meals per month (range 0-12). TSH, free (FT3) and total (TT3) triiodothyronine and free (FT4) and total (TT4) thyroxin in plasma were analyzed by immunofluorometric assays, and 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) in plasma was analyzed by gas chromatography with electron capture detection. Twenty other PCB and two hydroxy-PCB congeners were analyzed in subgroups of the women. Plasma lipid analyses were performed with enzymatic techniques.</p><p>RESULTS: The CB-153 concentration in plasma (range 16-776 ng/g lipid) was negatively correlated with the TT3 concentrations (range 1.0-3.0 nmol/l, rs = -0.29, P &lt; 0.001). This association remained after age adjustment.</p><p>CONCLUSIONS: The present study gives some support for the notion that dietary exposure to persistent organochlorine compounds (POCs) might weakly affect peripheral thyroid hormone concentrations in adult women.</p>}},
  author       = {{Hagmar, L and Rylander, L and Dyremark, E and Klasson-Wehler, E and Erfurth, E M}},
  issn         = {{0340-0131}},
  keywords     = {{Adult; Animals; Feeding Behavior; Female; Fishes; Fluoroimmunoassay; Food Contamination; Humans; Linear Models; Lipids/blood; Middle Aged; Polychlorinated Biphenyls/blood; Sweden/epidemiology; Thyroid Hormones/blood; Thyrotropin/blood}},
  language     = {{eng}},
  number       = {{3}},
  pages        = {{8--184}},
  publisher    = {{Springer}},
  series       = {{International Archives of Occupational and Environmental Health}},
  title        = {{Plasma concentrations of persistent organochlorines in relation to thyrotropin and thyroid hormone levels in women}},
  url          = {{http://dx.doi.org/10.1007/s004200000213}},
  doi          = {{10.1007/s004200000213}},
  volume       = {{74}},
  year         = {{2001}},
}