Advanced

Reproducibility of measurements with a semi-automatic software package for the evaluation of rectal cancer

Hörberg, Lisa LU ; Roth, Daniel LU ; Leander, Peter LU ; Månsson, Sven LU ; Fält, Tobias LU ; Ekberg, Olle LU and Zackrisson, Sophia LU (2019) In Acta Radiologica
Abstract

Background: Staging of rectal cancer with MRI has major impact on treatment choice and may be of importance in new cancer management strategies such as “wait-and-see” policy. Purpose: To assess the reproducibility of a software package recently developed at our department to measure volumes, apparent diffusion coefficient, and the skewness of apparent diffusion coefficient in lymph nodes and tumors in rectal cancer patients before and after chemoradiation treatment. Material and Methods: This study included 20 consecutive patients with biopsy-verified rectal cancer, in whom MRI staging had been performed both before and after chemoradiation treatment. The diffusion-weighted images were transferred to the software. The volume, apparent... (More)

Background: Staging of rectal cancer with MRI has major impact on treatment choice and may be of importance in new cancer management strategies such as “wait-and-see” policy. Purpose: To assess the reproducibility of a software package recently developed at our department to measure volumes, apparent diffusion coefficient, and the skewness of apparent diffusion coefficient in lymph nodes and tumors in rectal cancer patients before and after chemoradiation treatment. Material and Methods: This study included 20 consecutive patients with biopsy-verified rectal cancer, in whom MRI staging had been performed both before and after chemoradiation treatment. The diffusion-weighted images were transferred to the software. The volume, apparent diffusion coefficient, and skewness were determined for 93 lymph nodes and 40 tumors. The volumes were compared with manual measurements of the volume of the same lymph nodes and tumors. Results: The agreement in semi-automatic measurements of lymph nodes was very good (ICC = 0.99), and in tumors good (ICC = 0.88). The agreement in manual measurements of lymph nodes was very good (ICC = 0.95) when all lymph nodes were included, but low (ICC = 0.52) if three outliers were excluded. Bland–Altman plots showed clear agreement between manual and semi-automatic measurements in the lymph nodes, but not in measurements of tumors. The values of apparent diffusion coefficient and skewness in tumors differed before and after treatment but did not differ in lymph nodes as a group. Conclusion: The software package showed a high degree of reproducibility in measurements on lymph nodes but requires further development to improve the reproducibility of tumor measurements.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
computer systems evaluation, lymph nodes, magnetic resonance imaging, Rectal cancer
in
Acta Radiologica
publisher
John Wiley & Sons
external identifiers
  • scopus:85073917837
  • pmid:31510762
ISSN
0284-1851
DOI
10.1177/0284185119873118
language
English
LU publication?
yes
id
6c62cb3b-b3ab-4d24-9334-c3bbf9f03be0
date added to LUP
2019-11-06 12:05:13
date last changed
2019-11-25 09:35:33
@article{6c62cb3b-b3ab-4d24-9334-c3bbf9f03be0,
  abstract     = {<p>Background: Staging of rectal cancer with MRI has major impact on treatment choice and may be of importance in new cancer management strategies such as “wait-and-see” policy. Purpose: To assess the reproducibility of a software package recently developed at our department to measure volumes, apparent diffusion coefficient, and the skewness of apparent diffusion coefficient in lymph nodes and tumors in rectal cancer patients before and after chemoradiation treatment. Material and Methods: This study included 20 consecutive patients with biopsy-verified rectal cancer, in whom MRI staging had been performed both before and after chemoradiation treatment. The diffusion-weighted images were transferred to the software. The volume, apparent diffusion coefficient, and skewness were determined for 93 lymph nodes and 40 tumors. The volumes were compared with manual measurements of the volume of the same lymph nodes and tumors. Results: The agreement in semi-automatic measurements of lymph nodes was very good (ICC = 0.99), and in tumors good (ICC = 0.88). The agreement in manual measurements of lymph nodes was very good (ICC = 0.95) when all lymph nodes were included, but low (ICC = 0.52) if three outliers were excluded. Bland–Altman plots showed clear agreement between manual and semi-automatic measurements in the lymph nodes, but not in measurements of tumors. The values of apparent diffusion coefficient and skewness in tumors differed before and after treatment but did not differ in lymph nodes as a group. Conclusion: The software package showed a high degree of reproducibility in measurements on lymph nodes but requires further development to improve the reproducibility of tumor measurements.</p>},
  author       = {Hörberg, Lisa and Roth, Daniel and Leander, Peter and Månsson, Sven and Fält, Tobias and Ekberg, Olle and Zackrisson, Sophia},
  issn         = {0284-1851},
  language     = {eng},
  month        = {09},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Reproducibility of measurements with a semi-automatic software package for the evaluation of rectal cancer},
  url          = {http://dx.doi.org/10.1177/0284185119873118},
  doi          = {10.1177/0284185119873118},
  year         = {2019},
}