Does microbiological contamination of homografts prior to decontamination affect the outcome after right ventricular outflow tract reconstruction?
Axelsson, Ida LU ; Malm, Torsten LU and Nilsson, Johan LU
(2021)
In Interactive Cardiovascular and Thoracic Surgery
33(4).
p.605-613
- Abstract
OBJECTIVES: Homografts are often in short supply. Today, European guidelines recommend that all tissues contaminated by any of 18 different bacteria and fungi be discarded before antibiotic decontamination has been conducted. The tissue bank in Lund uses more liberal protocols: It accepts all microbes prior to decontamination except multiresistant microbes and Pseudomonas species. The aim of this study was to analyse the effect of contamination on the long-term outcome and occurrence of endocarditis in recipients. METHODS: Data were collected on homografts and on recipients of homografts in the right ventricular (RV) outflow tract who were operated on between 1995 and 2018 in Lund. The long-term outcome of recipients was analysed in... (More)
OBJECTIVES: Homografts are often in short supply. Today, European guidelines recommend that all tissues contaminated by any of 18 different bacteria and fungi be discarded before antibiotic decontamination has been conducted. The tissue bank in Lund uses more liberal protocols: It accepts all microbes prior to decontamination except multiresistant microbes and Pseudomonas species. The aim of this study was to analyse the effect of contamination on the long-term outcome and occurrence of endocarditis in recipients. METHODS: Data were collected on homografts and on recipients of homografts in the right ventricular (RV) outflow tract who were operated on between 1995 and 2018 in Lund. The long-term outcome of recipients was analysed in relation to different types of contamination using Cox proportional hazard regression. The proportion of patients with endocarditis was analysed with the χ2 test. RESULTS: The study included 509 implanted homografts. Follow-up was a maximum of 24 years and 99% complete. A total of 156 (31%) homografts were contaminated prior to antibiotic decontamination. Homografts contaminated with low-risk microbes had the lowest reintervention rate, but there was no significant difference compared to no contamination [hazard ratio (HR) 1.1, 95% confidence interval (CI) 0.73-1.7] or contamination with high-risk microbes (HR 1.6, 95% CI 0.87-2.8) in the multivariable analysis. There was no significant difference in the proportion of cases of endocarditis during the follow-up period between recipients of homografts contaminated prior to decontamination and recipients of homografts with no contamination (P = 0.83). CONCLUSIONS: Contamination of homograft tissue prior to decontamination did not show any significant effect on the long-term outcome or the occurrence of endocarditis after implantation in the RV outflow tract. Most contaminated homografts can be used safely after approved decontamination.
(Less)
- author
- Axelsson, Ida
LU
; Malm, Torsten
LU
and Nilsson, Johan
LU
- organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Contamination, Homograft, Long-term outcome, Right ventricular outflow tract, Tissue bank
- in
- Interactive Cardiovascular and Thoracic Surgery
- volume
- 33
- issue
- 4
- pages
- 9 pages
- publisher
- European Association of Cardio-Thoracic Surgery
- external identifiers
-
- pmid:34000042
- scopus:85117451142
- ISSN
- 1569-9293
- DOI
- 10.1093/icvts/ivab126
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © 2021 The Author(s). Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.
- id
- 6c962ece-3340-4d15-bffa-1d1dc7650383
- date added to LUP
- 2021-11-22 10:47:50
- date last changed
- 2024-10-20 10:30:34
@article{6c962ece-3340-4d15-bffa-1d1dc7650383,
abstract = {{<p>OBJECTIVES: Homografts are often in short supply. Today, European guidelines recommend that all tissues contaminated by any of 18 different bacteria and fungi be discarded before antibiotic decontamination has been conducted. The tissue bank in Lund uses more liberal protocols: It accepts all microbes prior to decontamination except multiresistant microbes and Pseudomonas species. The aim of this study was to analyse the effect of contamination on the long-term outcome and occurrence of endocarditis in recipients. METHODS: Data were collected on homografts and on recipients of homografts in the right ventricular (RV) outflow tract who were operated on between 1995 and 2018 in Lund. The long-term outcome of recipients was analysed in relation to different types of contamination using Cox proportional hazard regression. The proportion of patients with endocarditis was analysed with the χ2 test. RESULTS: The study included 509 implanted homografts. Follow-up was a maximum of 24 years and 99% complete. A total of 156 (31%) homografts were contaminated prior to antibiotic decontamination. Homografts contaminated with low-risk microbes had the lowest reintervention rate, but there was no significant difference compared to no contamination [hazard ratio (HR) 1.1, 95% confidence interval (CI) 0.73-1.7] or contamination with high-risk microbes (HR 1.6, 95% CI 0.87-2.8) in the multivariable analysis. There was no significant difference in the proportion of cases of endocarditis during the follow-up period between recipients of homografts contaminated prior to decontamination and recipients of homografts with no contamination (P = 0.83). CONCLUSIONS: Contamination of homograft tissue prior to decontamination did not show any significant effect on the long-term outcome or the occurrence of endocarditis after implantation in the RV outflow tract. Most contaminated homografts can be used safely after approved decontamination.</p>}},
author = {{Axelsson, Ida and Malm, Torsten and Nilsson, Johan}},
issn = {{1569-9293}},
keywords = {{Contamination; Homograft; Long-term outcome; Right ventricular outflow tract; Tissue bank}},
language = {{eng}},
number = {{4}},
pages = {{605--613}},
publisher = {{European Association of Cardio-Thoracic Surgery}},
series = {{Interactive Cardiovascular and Thoracic Surgery}},
title = {{Does microbiological contamination of homografts prior to decontamination affect the outcome after right ventricular outflow tract reconstruction?}},
url = {{http://dx.doi.org/10.1093/icvts/ivab126}},
doi = {{10.1093/icvts/ivab126}},
volume = {{33}},
year = {{2021}},
}