First comprehensive tool for screening pain in Parkinson's disease : the King's Parkinson's Disease Pain Questionnaire
(2018) In European Journal of Neurology 25(10). p.1255-1261- Abstract
Background and purpose: Pain is highly prevalent in Parkinson's disease (PD), impacting patients’ ability, mood and quality of life. Detecting the presence of pain in its multiple modalities is necessary for adequate personalized management of PD. A 14-item, PD-specific, patient-based questionnaire (the King's Parkinson's Disease Pain Questionnaire, KPPQ) was designed corresponding to the rater-based KPP Scale (KPPS). The present multicentre study was aimed at testing the validity of this screening tool. Methods: First, a comparison between the KPPQ scores of patients and matched controls was performed. Next, convergent validity, reproducibility (test–retest) and diagnostic performance of the questionnaire were analysed. Results: Data... (More)
Background and purpose: Pain is highly prevalent in Parkinson's disease (PD), impacting patients’ ability, mood and quality of life. Detecting the presence of pain in its multiple modalities is necessary for adequate personalized management of PD. A 14-item, PD-specific, patient-based questionnaire (the King's Parkinson's Disease Pain Questionnaire, KPPQ) was designed corresponding to the rater-based KPP Scale (KPPS). The present multicentre study was aimed at testing the validity of this screening tool. Methods: First, a comparison between the KPPQ scores of patients and matched controls was performed. Next, convergent validity, reproducibility (test–retest) and diagnostic performance of the questionnaire were analysed. Results: Data from 300 patients and 150 controls are reported. PD patients declared significantly more pain symptoms than controls (3.96 ± 2.56 vs. 2.17 ± 1.39; P < 0.0001). The KPPQ convergent validity was high with KPPS total score (rS = 0.80) but weak or moderate with other pain assessments. Test–retest reliability was satisfactory with kappa values ≥0.65 except for item 5, Dyskinetic pains (κ = 0.44), and the intraclass correlation coefficient (ICC) for the KPPQ total score was 0.98. After the scores of the KPPS were adapted for screening (0, no symptom; ≥1, symptom present), a good agreement was found between the KPPQ and the KPPS (ICC = 0.88). A strong correlation (rS = 0.80) between the two instruments was found. The diagnostic parameters of the KPPQ were very satisfactory as a whole, with a global accuracy of 78.3%–98.3%. Conclusions: These results suggest that the KPPQ is a useful, reliable and valid screening instrument for pain in PD to advance patient-related outcomes.
(Less)
- author
- author collaboration
- organization
- publishing date
- 2018
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- assessment, King's Parkinson's Disease Pain Questionnaire, pain, Parkinson's disease, screening, validation
- in
- European Journal of Neurology
- volume
- 25
- issue
- 10
- pages
- 7 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:29806962
- scopus:85053007934
- ISSN
- 1351-5101
- DOI
- 10.1111/ene.13691
- language
- English
- LU publication?
- yes
- id
- 6c9d7d1d-1a12-4f03-ba26-7b4603cd6171
- date added to LUP
- 2018-10-10 10:52:50
- date last changed
- 2024-07-24 00:17:02
@article{6c9d7d1d-1a12-4f03-ba26-7b4603cd6171, abstract = {{<p>Background and purpose: Pain is highly prevalent in Parkinson's disease (PD), impacting patients’ ability, mood and quality of life. Detecting the presence of pain in its multiple modalities is necessary for adequate personalized management of PD. A 14-item, PD-specific, patient-based questionnaire (the King's Parkinson's Disease Pain Questionnaire, KPPQ) was designed corresponding to the rater-based KPP Scale (KPPS). The present multicentre study was aimed at testing the validity of this screening tool. Methods: First, a comparison between the KPPQ scores of patients and matched controls was performed. Next, convergent validity, reproducibility (test–retest) and diagnostic performance of the questionnaire were analysed. Results: Data from 300 patients and 150 controls are reported. PD patients declared significantly more pain symptoms than controls (3.96 ± 2.56 vs. 2.17 ± 1.39; P < 0.0001). The KPPQ convergent validity was high with KPPS total score (r<sub>S</sub> = 0.80) but weak or moderate with other pain assessments. Test–retest reliability was satisfactory with kappa values ≥0.65 except for item 5, Dyskinetic pains (κ = 0.44), and the intraclass correlation coefficient (ICC) for the KPPQ total score was 0.98. After the scores of the KPPS were adapted for screening (0, no symptom; ≥1, symptom present), a good agreement was found between the KPPQ and the KPPS (ICC = 0.88). A strong correlation (r<sub>S</sub> = 0.80) between the two instruments was found. The diagnostic parameters of the KPPQ were very satisfactory as a whole, with a global accuracy of 78.3%–98.3%. Conclusions: These results suggest that the KPPQ is a useful, reliable and valid screening instrument for pain in PD to advance patient-related outcomes.</p>}}, author = {{Martinez-Martin, P. and Rizos, A. M. and Wetmore, J. and Antonini, A. and Odin, P. and Pal, S. and Sophia, R. and Carroll, C. and Martino, D. and Falup-Pecurariu, C. and Kessel, B. and Andrews, T. and Paviour, D. and Trenkwalder, C. and Chaudhuri, K. R.}}, issn = {{1351-5101}}, keywords = {{assessment; King's Parkinson's Disease Pain Questionnaire; pain; Parkinson's disease; screening; validation}}, language = {{eng}}, number = {{10}}, pages = {{1255--1261}}, publisher = {{Wiley-Blackwell}}, series = {{European Journal of Neurology}}, title = {{First comprehensive tool for screening pain in Parkinson's disease : the King's Parkinson's Disease Pain Questionnaire}}, url = {{http://dx.doi.org/10.1111/ene.13691}}, doi = {{10.1111/ene.13691}}, volume = {{25}}, year = {{2018}}, }