Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer

Huang, Wuqing LU orcid ; Sundquist, Jan LU ; Sundquist, Kristina LU and Ji, Jianguang LU orcid (2020) In Nature Communications 11(1). p.3191-3191
Abstract

Phosphodiesterase-5 (PDE5) inhibitors are suggested to have anti-tumor effects and to inhibit surgery-induced immunosuppression. We aimed to explore whether post-diagnostic use of PDE5 inhibitors was associated with a better prognosis among male patients with colorectal cancer (CRC) and the role of open surgery in the association. Here we show that post-diagnostic use of PDE5 inhibitors is associated with a decreased risk of CRC-specific mortality (adjusted HR = 0.82, 95% CI 0.67-0.99) as well as a decreased risk of metastasis (adjusted HR = 0.85, 95% CI 0.74-0.98). Specifically, post-operative use of PDE5 inhibitors has a strong anti-cancer effect. The reduced risk of metastasis is mainly due to distant metastasis but not regional... (More)

Phosphodiesterase-5 (PDE5) inhibitors are suggested to have anti-tumor effects and to inhibit surgery-induced immunosuppression. We aimed to explore whether post-diagnostic use of PDE5 inhibitors was associated with a better prognosis among male patients with colorectal cancer (CRC) and the role of open surgery in the association. Here we show that post-diagnostic use of PDE5 inhibitors is associated with a decreased risk of CRC-specific mortality (adjusted HR = 0.82, 95% CI 0.67-0.99) as well as a decreased risk of metastasis (adjusted HR = 0.85, 95% CI 0.74-0.98). Specifically, post-operative use of PDE5 inhibitors has a strong anti-cancer effect. The reduced risk of metastasis is mainly due to distant metastasis but not regional lymphatic metastasis. PDE5 inhibitors have the potential to be an adjuvant drug for patients with CRC to improve prognosis, especially those who have undergone open surgery.

(Less)
Please use this url to cite or link to this publication:
author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
11
issue
1
pages
3191 - 3191
publisher
Nature Publishing Group
external identifiers
  • scopus:85086889409
  • pmid:32581298
ISSN
2041-1723
DOI
10.1038/s41467-020-17028-4
language
English
LU publication?
yes
id
6ca3a0e7-fc0e-4eab-9de0-0bc62d5e3bf8
date added to LUP
2020-06-28 08:50:50
date last changed
2024-04-17 11:02:38
@article{6ca3a0e7-fc0e-4eab-9de0-0bc62d5e3bf8,
  abstract     = {{<p>Phosphodiesterase-5 (PDE5) inhibitors are suggested to have anti-tumor effects and to inhibit surgery-induced immunosuppression. We aimed to explore whether post-diagnostic use of PDE5 inhibitors was associated with a better prognosis among male patients with colorectal cancer (CRC) and the role of open surgery in the association. Here we show that post-diagnostic use of PDE5 inhibitors is associated with a decreased risk of CRC-specific mortality (adjusted HR = 0.82, 95% CI 0.67-0.99) as well as a decreased risk of metastasis (adjusted HR = 0.85, 95% CI 0.74-0.98). Specifically, post-operative use of PDE5 inhibitors has a strong anti-cancer effect. The reduced risk of metastasis is mainly due to distant metastasis but not regional lymphatic metastasis. PDE5 inhibitors have the potential to be an adjuvant drug for patients with CRC to improve prognosis, especially those who have undergone open surgery.</p>}},
  author       = {{Huang, Wuqing and Sundquist, Jan and Sundquist, Kristina and Ji, Jianguang}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  month        = {{06}},
  number       = {{1}},
  pages        = {{3191--3191}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer}},
  url          = {{http://dx.doi.org/10.1038/s41467-020-17028-4}},
  doi          = {{10.1038/s41467-020-17028-4}},
  volume       = {{11}},
  year         = {{2020}},
}