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Viruses, diabetes, and autoimmunity : Studies of subjects at genetic risk for type 1 diabetes

Lindehammer, Sabina Resic LU and Lernmark, Åke LU (2013) In Diabetes and Viruses 9781461440512. p.187-194
Abstract

The possible importance of virus infections before the development of islet autoimmunity and then for the appearance of clinical type 1 diabetes is reviewed. There is a lack of specific data on the role of virus to induce islet autoimmunity. There is also a paucity of data to demonstrate that virus infections may contribute to an accelerated disease process resulting in clinical onset of type 1 diabetes. In contrast, there is a plethora of studies on virus infections at the time of clinical onset. However, these studies have made the understanding of virus in type 1 diabetes less easy. Future studies need to address further gestational infections and the risk of the offspring for islet autoimmunity. Such studies should also investigate... (More)

The possible importance of virus infections before the development of islet autoimmunity and then for the appearance of clinical type 1 diabetes is reviewed. There is a lack of specific data on the role of virus to induce islet autoimmunity. There is also a paucity of data to demonstrate that virus infections may contribute to an accelerated disease process resulting in clinical onset of type 1 diabetes. In contrast, there is a plethora of studies on virus infections at the time of clinical onset. However, these studies have made the understanding of virus in type 1 diabetes less easy. Future studies need to address further gestational infections and the risk of the offspring for islet autoimmunity. Such studies should also investigate the mechanisms by which gestational infections may alter the ability of the offspring to respond to future virus infections related to the development of islet autoimmunity or accelerator of the clinical onset of diabetes.

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Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
Diabetes and Viruses
editor
Taylor, K. ; Hyöty, H.; Toniolo, A.; Zuckerman, A. J. ; ; ; and
volume
9781461440512
pages
8 pages
publisher
Springer New York LLC
external identifiers
  • scopus:84949180203
ISBN
9781461440512
9781461440505
DOI
10.1007/978-1-4614-4051-2_19
language
English
LU publication?
yes
id
6cdec998-f578-47b6-a744-03bdbd7300fb
date added to LUP
2017-09-07 11:42:35
date last changed
2018-05-29 11:12:42
@inbook{6cdec998-f578-47b6-a744-03bdbd7300fb,
  abstract     = {<p>The possible importance of virus infections before the development of islet autoimmunity and then for the appearance of clinical type 1 diabetes is reviewed. There is a lack of specific data on the role of virus to induce islet autoimmunity. There is also a paucity of data to demonstrate that virus infections may contribute to an accelerated disease process resulting in clinical onset of type 1 diabetes. In contrast, there is a plethora of studies on virus infections at the time of clinical onset. However, these studies have made the understanding of virus in type 1 diabetes less easy. Future studies need to address further gestational infections and the risk of the offspring for islet autoimmunity. Such studies should also investigate the mechanisms by which gestational infections may alter the ability of the offspring to respond to future virus infections related to the development of islet autoimmunity or accelerator of the clinical onset of diabetes.</p>},
  author       = {Lindehammer, Sabina Resic and Lernmark, Åke},
  editor       = {Taylor, K.  and Hyöty, H. and Toniolo, A. and Zuckerman, A. J. },
  isbn         = {9781461440512},
  language     = {eng},
  pages        = {187--194},
  publisher    = {Springer New York LLC},
  series       = {Diabetes and Viruses},
  title        = {Viruses, diabetes, and autoimmunity : Studies of subjects at genetic risk for type 1 diabetes},
  url          = {http://dx.doi.org/10.1007/978-1-4614-4051-2_19},
  volume       = {9781461440512},
  year         = {2013},
}