Heptemerones A-G, seven novel diterpenoids from Coprinus heptemerus: Producing organism, fermentation, isolation and biological activities
(2005) In Journal of Antibiotics 58(6). p.390-396- Abstract
- Seven novel diterpenoids, named heptemerones A-G, were isolated from the broth of submerged cultures of Coprinus heptemerus, a basidiomycete which previously had not been known to produce secondary metabolites. The compounds were purified by solid phase extraction and silica gel chromatography followed by preparative HPLC. Among the biological activities the inhibition of fungal germination was the most potent, and depended highly on the composition of the assay medium. In water, inhibition occurred at 5 similar to 10 fold lower concentrations as compared to complex media. Heptemerone G was the most active compound with MICs starting at 1 mu g/ml. Four of the antifungal compounds exhibited plant protective activity in a leaf segment assay... (More)
- Seven novel diterpenoids, named heptemerones A-G, were isolated from the broth of submerged cultures of Coprinus heptemerus, a basidiomycete which previously had not been known to produce secondary metabolites. The compounds were purified by solid phase extraction and silica gel chromatography followed by preparative HPLC. Among the biological activities the inhibition of fungal germination was the most potent, and depended highly on the composition of the assay medium. In water, inhibition occurred at 5 similar to 10 fold lower concentrations as compared to complex media. Heptemerone G was the most active compound with MICs starting at 1 mu g/ml. Four of the antifungal compounds exhibited plant protective activity in a leaf segment assay using Magnaporthe grisea as the pathogen. Growth of yeasts and bacteria was hardly affected. Cytotoxic activities were moderate and only heptemerone D was phytotoxic. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/152385
- author
- Kettering, M ; Valdivia, Carola LU ; Sterner, Olov LU ; Anke, H and Thines, E
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Antibiotics
- volume
- 58
- issue
- 6
- pages
- 390 - 396
- publisher
- Japan Antibiotics Research Association
- external identifiers
-
- wos:000230261300003
- pmid:16156515
- scopus:22444434591
- ISSN
- 0021-8820
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)
- id
- 6d3def7c-327a-41e4-9d90-125b1dd00239 (old id 152385)
- alternative location
- http://www.antibiotics.or.jp/journal/ja-top.htm
- date added to LUP
- 2016-04-01 16:51:36
- date last changed
- 2022-03-30 18:48:41
@article{6d3def7c-327a-41e4-9d90-125b1dd00239,
abstract = {{Seven novel diterpenoids, named heptemerones A-G, were isolated from the broth of submerged cultures of Coprinus heptemerus, a basidiomycete which previously had not been known to produce secondary metabolites. The compounds were purified by solid phase extraction and silica gel chromatography followed by preparative HPLC. Among the biological activities the inhibition of fungal germination was the most potent, and depended highly on the composition of the assay medium. In water, inhibition occurred at 5 similar to 10 fold lower concentrations as compared to complex media. Heptemerone G was the most active compound with MICs starting at 1 mu g/ml. Four of the antifungal compounds exhibited plant protective activity in a leaf segment assay using Magnaporthe grisea as the pathogen. Growth of yeasts and bacteria was hardly affected. Cytotoxic activities were moderate and only heptemerone D was phytotoxic.}},
author = {{Kettering, M and Valdivia, Carola and Sterner, Olov and Anke, H and Thines, E}},
issn = {{0021-8820}},
language = {{eng}},
number = {{6}},
pages = {{390--396}},
publisher = {{Japan Antibiotics Research Association}},
series = {{Journal of Antibiotics}},
title = {{Heptemerones A-G, seven novel diterpenoids from Coprinus heptemerus: Producing organism, fermentation, isolation and biological activities}},
url = {{http://www.antibiotics.or.jp/journal/ja-top.htm}},
volume = {{58}},
year = {{2005}},
}