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Putaminal T1/T2-weighted ratio is increased in PSP compared to PD and healthy controls, a multi-cohort study

Sjöström, Henrik ; van Westen, Danielle LU orcid ; Hall, Sara LU ; Tjerkaski, Jonathan ; Westman, Eric ; Muehlboeck, Sebastian ; Hansson, Oskar LU orcid ; Svenningsson, Per and Granberg, Tobias (2024) In Parkinsonism and Related Disorders 121.
Abstract

Introduction: Differentiating Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is a common clinical problem. We aimed to apply the T1-/T2-weighted ratio imaging technique, based on standard clinical MRI, to reveal differences in neurodegeneration in three large cohorts. Methods: Three cohorts, with a total of 405 participants (269 PD, 44 PSP, 38 MSA, 54 controls), were combined and T1/T2-weighted ratio image analyses were carried out. A combination of automatic segmentation and atlas-based ROI were used in this study. The cohorts were combined using the ComBat batch correction procedure. Results: Group differences were found in the putamen (p... (More)

Introduction: Differentiating Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is a common clinical problem. We aimed to apply the T1-/T2-weighted ratio imaging technique, based on standard clinical MRI, to reveal differences in neurodegeneration in three large cohorts. Methods: Three cohorts, with a total of 405 participants (269 PD, 44 PSP, 38 MSA, 54 controls), were combined and T1/T2-weighted ratio image analyses were carried out. A combination of automatic segmentation and atlas-based ROI were used in this study. The cohorts were combined using the ComBat batch correction procedure. Results: Group differences were found in the putamen (p = 0.040), with higher T1/T2-weighted ratio in this region in PSP compared to PD and healthy controls (p-values 0.010 and 0.007 respectively). Using putaminal T1/T2-weighted ratio for diagnostic separation, a fair performance was found in separating PSP from healthy controls, with an area under the receiver operating characteristic curve of 0.701. Conclusion: Different patterns of T1/T2-weighted ratio, reflecting differences in underlying pathophysiology, were found between the groups. Since T1/T2-weighted ratio can be applied to standard clinical MRI sequences to allow more quantitative analyses, this seems to be a promising biomarker for diagnostics and treatment evaluation of parkinsonian disorders for clinical trials.

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author
; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Parkinsonism and Related Disorders
volume
121
article number
106047
publisher
Elsevier
external identifiers
  • pmid:38368753
  • scopus:85185529185
ISSN
1353-8020
DOI
10.1016/j.parkreldis.2024.106047
language
English
LU publication?
yes
id
6d9cffa1-77fe-428f-9200-c5a4a01154a5
date added to LUP
2024-03-14 12:36:42
date last changed
2024-04-25 09:15:51
@article{6d9cffa1-77fe-428f-9200-c5a4a01154a5,
  abstract     = {{<p>Introduction: Differentiating Parkinson's disease (PD) from progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) is a common clinical problem. We aimed to apply the T<sub>1</sub>-/T<sub>2</sub>-weighted ratio imaging technique, based on standard clinical MRI, to reveal differences in neurodegeneration in three large cohorts. Methods: Three cohorts, with a total of 405 participants (269 PD, 44 PSP, 38 MSA, 54 controls), were combined and T<sub>1</sub>/T<sub>2</sub>-weighted ratio image analyses were carried out. A combination of automatic segmentation and atlas-based ROI were used in this study. The cohorts were combined using the ComBat batch correction procedure. Results: Group differences were found in the putamen (p = 0.040), with higher T<sub>1</sub>/T<sub>2</sub>-weighted ratio in this region in PSP compared to PD and healthy controls (p-values 0.010 and 0.007 respectively). Using putaminal T<sub>1</sub>/T<sub>2</sub>-weighted ratio for diagnostic separation, a fair performance was found in separating PSP from healthy controls, with an area under the receiver operating characteristic curve of 0.701. Conclusion: Different patterns of T<sub>1</sub>/T<sub>2</sub>-weighted ratio, reflecting differences in underlying pathophysiology, were found between the groups. Since T<sub>1</sub>/T<sub>2</sub>-weighted ratio can be applied to standard clinical MRI sequences to allow more quantitative analyses, this seems to be a promising biomarker for diagnostics and treatment evaluation of parkinsonian disorders for clinical trials.</p>}},
  author       = {{Sjöström, Henrik and van Westen, Danielle and Hall, Sara and Tjerkaski, Jonathan and Westman, Eric and Muehlboeck, Sebastian and Hansson, Oskar and Svenningsson, Per and Granberg, Tobias}},
  issn         = {{1353-8020}},
  language     = {{eng}},
  publisher    = {{Elsevier}},
  series       = {{Parkinsonism and Related Disorders}},
  title        = {{Putaminal T1/T2-weighted ratio is increased in PSP compared to PD and healthy controls, a multi-cohort study}},
  url          = {{http://dx.doi.org/10.1016/j.parkreldis.2024.106047}},
  doi          = {{10.1016/j.parkreldis.2024.106047}},
  volume       = {{121}},
  year         = {{2024}},
}