Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome
(2020) In Journal of Internal Medicine 287(5). p.493-513- Abstract
Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins in the arterial wall. The biologic composition of an atherosclerotic plaque determines whether the plaque is more or less vulnerable, that is prone to rupture or erosion. Here, the ECM and tissue repair play an important role in plaque stability, vulnerability and progression. This review will focus on ECM remodelling in atherosclerotic plaques, with focus on how ECM biomarkers might predict plaque vulnerability and outcome.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/6db5a736-17a8-418c-af35-f20847d9da4a
- author
- Holm Nielsen, S. ; Jonasson, L. ; Kalogeropoulos, K. ; Karsdal, M. A. ; Reese-Petersen, A. L. ; auf dem Keller, U. ; Genovese, F. ; Nilsson, J. LU and Goncalves, I. LU
- organization
- publishing date
- 2020-05
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- atherosclerosis, biomarkers, extracellular matrix, outcome, vulnerable plaque
- in
- Journal of Internal Medicine
- volume
- 287
- issue
- 5
- pages
- 21 pages
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:32012358
- scopus:85081033500
- ISSN
- 0954-6820
- DOI
- 10.1111/joim.13034
- language
- English
- LU publication?
- yes
- id
- 6db5a736-17a8-418c-af35-f20847d9da4a
- date added to LUP
- 2020-03-19 15:48:52
- date last changed
- 2024-09-19 19:06:06
@article{6db5a736-17a8-418c-af35-f20847d9da4a, abstract = {{<p>Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins in the arterial wall. The biologic composition of an atherosclerotic plaque determines whether the plaque is more or less vulnerable, that is prone to rupture or erosion. Here, the ECM and tissue repair play an important role in plaque stability, vulnerability and progression. This review will focus on ECM remodelling in atherosclerotic plaques, with focus on how ECM biomarkers might predict plaque vulnerability and outcome.</p>}}, author = {{Holm Nielsen, S. and Jonasson, L. and Kalogeropoulos, K. and Karsdal, M. A. and Reese-Petersen, A. L. and auf dem Keller, U. and Genovese, F. and Nilsson, J. and Goncalves, I.}}, issn = {{0954-6820}}, keywords = {{atherosclerosis; biomarkers; extracellular matrix; outcome; vulnerable plaque}}, language = {{eng}}, number = {{5}}, pages = {{493--513}}, publisher = {{Wiley-Blackwell}}, series = {{Journal of Internal Medicine}}, title = {{Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome}}, url = {{http://dx.doi.org/10.1111/joim.13034}}, doi = {{10.1111/joim.13034}}, volume = {{287}}, year = {{2020}}, }