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Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome

Holm Nielsen, S. ; Jonasson, L. ; Kalogeropoulos, K. ; Karsdal, M. A. ; Reese-Petersen, A. L. ; auf dem Keller, U. ; Genovese, F. ; Nilsson, J. LU and Goncalves, I. LU (2020) In Journal of Internal Medicine
Abstract

Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins in the arterial wall. The biologic composition of an atherosclerotic plaque determines whether the plaque is more or less vulnerable, that is prone to rupture or erosion. Here, the ECM and tissue repair play an important role in plaque stability, vulnerability and progression. This review will focus on ECM remodelling in atherosclerotic plaques, with focus on how ECM biomarkers might predict plaque vulnerability and outcome.

Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
atherosclerosis, biomarkers, extracellular matrix, outcome, vulnerable plaque
in
Journal of Internal Medicine
publisher
Wiley-Blackwell Publishing Ltd
external identifiers
  • scopus:85081033500
  • pmid:32012358
ISSN
0954-6820
DOI
10.1111/joim.13034
language
English
LU publication?
yes
id
6db5a736-17a8-418c-af35-f20847d9da4a
date added to LUP
2020-03-19 15:48:52
date last changed
2020-05-26 05:40:57
@article{6db5a736-17a8-418c-af35-f20847d9da4a,
  abstract     = {<p>Cardiovascular disease (CVD) is the most common cause of death in industrialized countries. One underlying cause is atherosclerosis, which is a systemic disease characterized by plaques of retained lipids, inflammatory cells, apoptotic cells, calcium and extracellular matrix (ECM) proteins in the arterial wall. The biologic composition of an atherosclerotic plaque determines whether the plaque is more or less vulnerable, that is prone to rupture or erosion. Here, the ECM and tissue repair play an important role in plaque stability, vulnerability and progression. This review will focus on ECM remodelling in atherosclerotic plaques, with focus on how ECM biomarkers might predict plaque vulnerability and outcome.</p>},
  author       = {Holm Nielsen, S. and Jonasson, L. and Kalogeropoulos, K. and Karsdal, M. A. and Reese-Petersen, A. L. and auf dem Keller, U. and Genovese, F. and Nilsson, J. and Goncalves, I.},
  issn         = {0954-6820},
  language     = {eng},
  month        = {02},
  publisher    = {Wiley-Blackwell Publishing Ltd},
  series       = {Journal of Internal Medicine},
  title        = {Exploring the role of extracellular matrix proteins to develop biomarkers of plaque vulnerability and outcome},
  url          = {http://dx.doi.org/10.1111/joim.13034},
  doi          = {10.1111/joim.13034},
  year         = {2020},
}