The rat gastric phospholipids : Increased in ulcerated mucosa and decreased after healing
Dunjić, B. S. ; Svensson, I. LU ; Axelson, J. LU ; Adlercreutz, P. LU
; Ar’ Rajab, A.
and Bengmark, S.
LU
(1993)
In European Surgical Research
25(6).
p.376-382
- Abstract
The composition and content of the gastric phospholipids were followed during development and healing of indometha-cin-induced chronic, antral ulcers in rats. The individual phospholipids were identified by thin-layer chromatography and quantitatively estimated by spectrophotometric analysis of phosphate. No changes were found in phospholipid composition and content after a 24-hour fast or during the first 24 h after indomethacin was given. The total phospholipid content and the content of lysophosphatidylcholine and phosphatidylcholine were increased on the 5th day, when chronic ulcers were established. After 4 weeks, when the ulcers were healed, the total phospholipid content, and content of phosphatidylcholine,... (More)
The composition and content of the gastric phospholipids were followed during development and healing of indometha-cin-induced chronic, antral ulcers in rats. The individual phospholipids were identified by thin-layer chromatography and quantitatively estimated by spectrophotometric analysis of phosphate. No changes were found in phospholipid composition and content after a 24-hour fast or during the first 24 h after indomethacin was given. The total phospholipid content and the content of lysophosphatidylcholine and phosphatidylcholine were increased on the 5th day, when chronic ulcers were established. After 4 weeks, when the ulcers were healed, the total phospholipid content, and content of phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol, respectively, were decreased, while the content of lysophosphatidylcholine was increased. In conclusion, the composition and content of gastric phospholipids were altered in rats with ulcers as well as in rats with healed ulcers.
(Less)
- author
- Dunjić, B. S.
; Svensson, I.
LU
; Axelson, J.
LU
; Adlercreutz, P.
LU
; Ar’ Rajab, A.
and Bengmark, S.
LU
- organization
- publishing date
- 1993-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Chronic ulcer, Fatty acids, Gastric mucosa, Indomethacin, Lysophosphatidylcholine, Phosphatidylcholine, Phosphatidylethanolamine, Phosphatidylinositol, Rat, Sphingomyelin
- in
- European Surgical Research
- volume
- 25
- issue
- 6
- pages
- 7 pages
- publisher
- Karger
- external identifiers
-
- scopus:0027525433
- pmid:8276037
- ISSN
- 0014-312X
- DOI
- 10.1159/000129304
- language
- English
- LU publication?
- yes
- id
- 6dba4dbe-0291-4a49-a834-1dbe91925581
- date added to LUP
- 2019-06-22 09:18:01
- date last changed
- 2024-01-01 12:18:19
@article{6dba4dbe-0291-4a49-a834-1dbe91925581,
abstract = {{<p>The composition and content of the gastric phospholipids were followed during development and healing of indometha-cin-induced chronic, antral ulcers in rats. The individual phospholipids were identified by thin-layer chromatography and quantitatively estimated by spectrophotometric analysis of phosphate. No changes were found in phospholipid composition and content after a 24-hour fast or during the first 24 h after indomethacin was given. The total phospholipid content and the content of lysophosphatidylcholine and phosphatidylcholine were increased on the 5th day, when chronic ulcers were established. After 4 weeks, when the ulcers were healed, the total phospholipid content, and content of phosphatidylcholine, phosphatidylethanolamine and phosphatidylinositol, respectively, were decreased, while the content of lysophosphatidylcholine was increased. In conclusion, the composition and content of gastric phospholipids were altered in rats with ulcers as well as in rats with healed ulcers.</p>}},
author = {{Dunjić, B. S. and Svensson, I. and Axelson, J. and Adlercreutz, P. and Ar’ Rajab, A. and Bengmark, S.}},
issn = {{0014-312X}},
keywords = {{Chronic ulcer; Fatty acids; Gastric mucosa; Indomethacin; Lysophosphatidylcholine; Phosphatidylcholine; Phosphatidylethanolamine; Phosphatidylinositol; Rat; Sphingomyelin}},
language = {{eng}},
month = {{01}},
number = {{6}},
pages = {{376--382}},
publisher = {{Karger}},
series = {{European Surgical Research}},
title = {{The rat gastric phospholipids : Increased in ulcerated mucosa and decreased after healing}},
url = {{http://dx.doi.org/10.1159/000129304}},
doi = {{10.1159/000129304}},
volume = {{25}},
year = {{1993}},
}