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Sex differences in oncogenic mutational processes

Li, Constance H. ; Prokopec, Stephenie D. ; Sun, Ren X. ; Yousif, Fouad ; Schmitz, Nathaniel ; Al-Shahrour, Fatima ; Atwal, Gurnit ; Bailey, Peter J. ; Biankin, Andrew V. and Boutros, Paul C. , et al. (2020) In Nature Communications 11.
Abstract

Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational... (More)

Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nature Communications
volume
11
article number
4330
pages
24 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85079052881
  • pmid:32859912
ISSN
2041-1723
DOI
10.1038/s41467-020-17359-2
language
English
LU publication?
yes
id
6ddb9392-66a3-47fe-8507-d086dce1b12a
date added to LUP
2021-01-12 22:32:40
date last changed
2024-02-17 12:13:40
@article{6ddb9392-66a3-47fe-8507-d086dce1b12a,
  abstract     = {{<p>Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside the sex organs. Efforts to link these clinical differences to specific molecular features have focused on somatic mutations within the coding regions of the genome. Here we report a pan-cancer analysis of sex differences in whole genomes of 1983 tumours of 28 subtypes as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium. We both confirm the results of exome studies, and also uncover previously undescribed sex differences. These include sex-biases in coding and non-coding cancer drivers, mutation prevalence and strikingly, in mutational signatures related to underlying mutational processes. These results underline the pervasiveness of molecular sex differences and strengthen the call for increased consideration of sex in molecular cancer research.</p>}},
  author       = {{Li, Constance H. and Prokopec, Stephenie D. and Sun, Ren X. and Yousif, Fouad and Schmitz, Nathaniel and Al-Shahrour, Fatima and Atwal, Gurnit and Bailey, Peter J. and Biankin, Andrew V. and Boutros, Paul C. and Campbell, Peter J. and Chang, David K. and Cooke, Susanna L. and Deshpande, Vikram and Faltas, Bishoy M. and Faquin, William C. and Garraway, Levi and Getz, Gad and Grimmond, Sean M. and Haider, Syed and Hoadley, Katherine A. and Jiao, Wei and Kaiser, Vera B. and Karlić, Rosa and Kato, Mamoru and Kübler, Kirsten and Lazar, Alexander J. and Wright, Derek W. and Borg, Ake and Davis, Ian J. and Ehinger, Anna and Glodzik, Dominik and Grabau, Dorthe and Huang, Mi Ni and Johansson, Peter A. and Larsson, Erik and Li, Chang and Li, Haiyan Irene and Li, Jun and Möller, Peter and Ringnér, Markus and Song, Lei and Staaf, Johan and Wang, Jian and Wang, Qi and Yang, Yang and Zhang, Fan and Zhang, Jing and Zhang, Yan}},
  issn         = {{2041-1723}},
  language     = {{eng}},
  month        = {{08}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Nature Communications}},
  title        = {{Sex differences in oncogenic mutational processes}},
  url          = {{http://dx.doi.org/10.1038/s41467-020-17359-2}},
  doi          = {{10.1038/s41467-020-17359-2}},
  volume       = {{11}},
  year         = {{2020}},
}