Depression was associated with younger age, female sex, obesity, smoking, and physical inactivity, in 1027 patients with newly diagnosed type 2 diabetes : a Swedish multicentre cross-sectional study
(2022) In BMC Endocrine Disorders 22(1).- Abstract
Background: Depression is a risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). The aims were to explore the prevalence of depression, anxiety, antidepressant use, obesity, Hemoglobin A1c > 64 mmol/mol, life-style factors, pre-existing CVD, in patients with newly diagnosed T2D; to explore associations with depression; and to compare with Swedish general population data. Methods: Multicentre, cross-sectional study. Inclusion criteria: adults with serologically verified newly diagnosed T2D. Included variables: age, sex, current depression and anxiety (Hospital Anxiety and Depression Scale), previous depression, antidepressant use, obesity (BMI ≥ 30 and ≥ 40 kg/m2), Hemoglobin A1c, pre-existing CVD.... (More)
Background: Depression is a risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). The aims were to explore the prevalence of depression, anxiety, antidepressant use, obesity, Hemoglobin A1c > 64 mmol/mol, life-style factors, pre-existing CVD, in patients with newly diagnosed T2D; to explore associations with depression; and to compare with Swedish general population data. Methods: Multicentre, cross-sectional study. Inclusion criteria: adults with serologically verified newly diagnosed T2D. Included variables: age, sex, current depression and anxiety (Hospital Anxiety and Depression Scale), previous depression, antidepressant use, obesity (BMI ≥ 30 and ≥ 40 kg/m2), Hemoglobin A1c, pre-existing CVD. Logistic regression analyses were performed. Results: In 1027 T2D patients, aged 18–94 years, depression was associated with age (per year) (inversely) (odds ratio (OR) 0.97), anxiety (OR 12.2), previous depression (OR 7.1), antidepressant use (OR 4.2), BMI ≥ 30 kg/m2 (OR 1.7), BMI ≥ 40 kg/m2 (OR 2.3), smoking (OR 1.9), physical inactivity (OR 1.8), and women (OR 1.6) (all p ≤ 0.013). Younger women (n = 113), ≤ 59 years, compared to younger men (n = 217) had higher prevalence of current depression (31% vs 12%), previous depression (43 vs 19%), anxiety (42% vs 25%), antidepressant use (37% vs 12%), BMI ≥ 30 kg/m2 (73% vs 60%) and BMI ≥ 40 kg/m2) (18% vs 9%), and smoking (26% vs 16%) (all p ≤ 0.029). Older women (n = 297), ≥ 60 years, compared to older men (n = 400) had higher prevalence of previous depression (45% vs 12%), anxiety (18% vs 10%), antidepressant use (20% vs 8%), BMI ≥ 30 kg/m2 (55% vs 47%), BMI ≥ 40 kg/m2 (7% vs 3%) (all p ≤ 0.048), but not of current depression (both 9%). Compared to the Swedish general population (depression (women 11.2%, men 12.3%) and antidepressant use (women 9.8%, men 5.3%)), the younger women had higher prevalence of current depression, and all patients had higher prevalence of antidepressant use. Conclusions: In patients with newly diagnosed T2D, the younger women had the highest prevalence of depression, anxiety, and obesity. The prevalence of depression in young women and antidepressant use in all patients were higher than in the Swedish general population. Three risk factors for CVD, obesity, smoking, and physical inactivity, were associated with depression.
(Less)
- author
- Melin, Eva O. LU ; Wanby, Pär ; Neumark, Thomas ; Holmberg, Sara LU ; Neumark, Ann Sofi Nilsson ; Johansson, Karin ; Landin-Olsson, Mona LU ; Thulesius, Hans LU ; Hillman, Magnus LU and Thunander, Maria LU
- organization
-
- Diabetes lab (research group)
- Environmental Epidemiology (research group)
- Division of Occupational and Environmental Medicine, Lund University
- EpiHealth: Epidemiology for Health
- Family Medicine and Community Medicine (research group)
- EXODIAB: Excellence of Diabetes Research in Sweden
- Translational Muscle Research (research group)
- publishing date
- 2022
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Age, Antidepressants, Anxiety, Depression, Epidemiology, Obesity, Physical inactivity, Sex differences, Smoking, Type 2 diabetes
- in
- BMC Endocrine Disorders
- volume
- 22
- issue
- 1
- article number
- 273
- publisher
- BioMed Central (BMC)
- external identifiers
-
- scopus:85141612427
- pmid:36348470
- ISSN
- 1472-6823
- DOI
- 10.1186/s12902-022-01184-3
- language
- English
- LU publication?
- yes
- id
- 6e2bf361-47a9-44d1-a866-5e7988daa8fb
- date added to LUP
- 2022-12-05 12:03:20
- date last changed
- 2024-06-13 20:58:08
@article{6e2bf361-47a9-44d1-a866-5e7988daa8fb,
abstract = {{<p>Background: Depression is a risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). The aims were to explore the prevalence of depression, anxiety, antidepressant use, obesity, Hemoglobin A1c > 64 mmol/mol, life-style factors, pre-existing CVD, in patients with newly diagnosed T2D; to explore associations with depression; and to compare with Swedish general population data. Methods: Multicentre, cross-sectional study. Inclusion criteria: adults with serologically verified newly diagnosed T2D. Included variables: age, sex, current depression and anxiety (Hospital Anxiety and Depression Scale), previous depression, antidepressant use, obesity (BMI ≥ 30 and ≥ 40 kg/m<sup>2</sup>), Hemoglobin A1c, pre-existing CVD. Logistic regression analyses were performed. Results: In 1027 T2D patients, aged 18–94 years, depression was associated with age (per year) (inversely) (odds ratio (OR) 0.97), anxiety (OR 12.2), previous depression (OR 7.1), antidepressant use (OR 4.2), BMI ≥ 30 kg/m<sup>2</sup> (OR 1.7), BMI ≥ 40 kg/m<sup>2</sup> (OR 2.3), smoking (OR 1.9), physical inactivity (OR 1.8), and women (OR 1.6) (all p ≤ 0.013). Younger women (n = 113), ≤ 59 years, compared to younger men (n = 217) had higher prevalence of current depression (31% vs 12%), previous depression (43 vs 19%), anxiety (42% vs 25%), antidepressant use (37% vs 12%), BMI ≥ 30 kg/m<sup>2</sup> (73% vs 60%) and BMI ≥ 40 kg/m<sup>2</sup>) (18% vs 9%), and smoking (26% vs 16%) (all p ≤ 0.029). Older women (n = 297), ≥ 60 years, compared to older men (n = 400) had higher prevalence of previous depression (45% vs 12%), anxiety (18% vs 10%), antidepressant use (20% vs 8%), BMI ≥ 30 kg/m<sup>2</sup> (55% vs 47%), BMI ≥ 40 kg/m<sup>2</sup> (7% vs 3%) (all p ≤ 0.048), but not of current depression (both 9%). Compared to the Swedish general population (depression (women 11.2%, men 12.3%) and antidepressant use (women 9.8%, men 5.3%)), the younger women had higher prevalence of current depression, and all patients had higher prevalence of antidepressant use. Conclusions: In patients with newly diagnosed T2D, the younger women had the highest prevalence of depression, anxiety, and obesity. The prevalence of depression in young women and antidepressant use in all patients were higher than in the Swedish general population. Three risk factors for CVD, obesity, smoking, and physical inactivity, were associated with depression.</p>}},
author = {{Melin, Eva O. and Wanby, Pär and Neumark, Thomas and Holmberg, Sara and Neumark, Ann Sofi Nilsson and Johansson, Karin and Landin-Olsson, Mona and Thulesius, Hans and Hillman, Magnus and Thunander, Maria}},
issn = {{1472-6823}},
keywords = {{Age; Antidepressants; Anxiety; Depression; Epidemiology; Obesity; Physical inactivity; Sex differences; Smoking; Type 2 diabetes}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{BMC Endocrine Disorders}},
title = {{Depression was associated with younger age, female sex, obesity, smoking, and physical inactivity, in 1027 patients with newly diagnosed type 2 diabetes : a Swedish multicentre cross-sectional study}},
url = {{http://dx.doi.org/10.1186/s12902-022-01184-3}},
doi = {{10.1186/s12902-022-01184-3}},
volume = {{22}},
year = {{2022}},
}