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Stardardization Developments for Large Scale Biobanks in Smoking Related Diseases - A Model System for Blood Sample Processing and Storage

Malm, Johan LU ; Fehniger, Thomas LU ; Danmyr, Pia LU ; Végvári, Ákos LU ; Welinder, Charlotte LU ; Lindberg, Henrik LU ; Upton, Paul ; Carter, Stephanie ; Appelqvist, Roger LU and Sjödin, Karin LU , et al. (2013) In Translational Respiratory Medicine 1.
Abstract
Biobank samples stored in biobanks give researchers and respiratory healthcare institutions access to datasets of analytes valuable for both diagnostic and research practices. The usefulness of these samples in clinical decision-making is highly dependent on their quality and integrity. New procedures that better preserve sample integrity and reduce degradation are being developed to meet the needs of both present and future biobanking. Hereby we present an automatic sample workflow scheme that is designed to handle high numbers of blood samples. Blood fractions are aliquoted, heat sealed using novel technology, and stored in 384 tube high-density sample arrays. The newly developed 384 biobank rack system is especially suited for... (More)
Biobank samples stored in biobanks give researchers and respiratory healthcare institutions access to datasets of analytes valuable for both diagnostic and research practices. The usefulness of these samples in clinical decision-making is highly dependent on their quality and integrity. New procedures that better preserve sample integrity and reduce degradation are being developed to meet the needs of both present and future biobanking. Hereby we present an automatic sample workflow scheme that is designed to handle high numbers of blood samples. Blood fractions are aliquoted, heat sealed using novel technology, and stored in 384 tube high-density sample arrays. The newly developed 384 biobank rack system is especially suited for preserving identical small aliquots. This technology development allows rapid access to a given sample in the frozen archive while maintaining individual sample integrity with sample tube confinement and quality management. We provide data on robotic processing of clinical samples at -80°C, following initial processing, analysis and shipping between laboratories throughout Europe. Subsequent to unpacking, re-sorting, and storage at these sites, the samples have been returned for analysis. Biomarker analysis of 13 common tests in the clinical chemistry unit of the hospital provides evidence of qualitative and stable logistics using the 384-sample tube system. (Less)
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subject
keywords
Biobank, Biomarkers, Standardization, Robotics, Respiratory diseases
in
Translational Respiratory Medicine
volume
1
article number
14
publisher
Springer Open
external identifiers
  • pmid:27234395
ISSN
2213-0802
DOI
10.1186/2213-0802-1-14
language
English
LU publication?
yes
id
6e78347a-1f1f-450a-b282-4cebff2413cd (old id 3970502)
date added to LUP
2016-04-01 14:27:14
date last changed
2019-03-13 13:29:15
@article{6e78347a-1f1f-450a-b282-4cebff2413cd,
  abstract     = {Biobank samples stored in biobanks give researchers and respiratory healthcare institutions access to datasets of analytes valuable for both diagnostic and research practices. The usefulness of these samples in clinical decision-making is highly dependent on their quality and integrity. New procedures that better preserve sample integrity and reduce degradation are being developed to meet the needs of both present and future biobanking. Hereby we present an automatic sample workflow scheme that is designed to handle high numbers of blood samples. Blood fractions are aliquoted, heat sealed using novel technology, and stored in 384 tube high-density sample arrays. The newly developed 384 biobank rack system is especially suited for preserving identical small aliquots. This technology development allows rapid access to a given sample in the frozen archive while maintaining individual sample integrity with sample tube confinement and quality management. We provide data on robotic processing of clinical samples at -80°C, following initial processing, analysis and shipping between laboratories throughout Europe. Subsequent to unpacking, re-sorting, and storage at these sites, the samples have been returned for analysis. Biomarker analysis of 13 common tests in the clinical chemistry unit of the hospital provides evidence of qualitative and stable logistics using the 384-sample tube system.},
  author       = {Malm, Johan and Fehniger, Thomas and Danmyr, Pia and Végvári, Ákos and Welinder, Charlotte and Lindberg, Henrik and Upton, Paul and Carter, Stephanie and Appelqvist, Roger and Sjödin, Karin and Wieslander, Elisabet and Dahlbäck, Magnus and Rezeli, Melinda and Erlinge, David and Marko-Varga, György},
  issn         = {2213-0802},
  language     = {eng},
  publisher    = {Springer Open},
  series       = {Translational Respiratory Medicine},
  title        = {Stardardization Developments for Large Scale Biobanks in Smoking Related Diseases - A Model System for Blood Sample Processing and Storage},
  url          = {http://dx.doi.org/10.1186/2213-0802-1-14},
  doi          = {10.1186/2213-0802-1-14},
  volume       = {1},
  year         = {2013},
}