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Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil : A fundamental complement to therapeutics

Verissimo, Luis M.P. ; Cabral, Inês ; Cabral, Ana M.T.D.P.V. ; Utzeri, Gianluca LU orcid ; Veiga, Francisco J.B. ; Valente, Artur J.M. and Ribeiro, Ana C.F. (2021) In Journal of Chemical Thermodynamics 161.
Abstract

Cancer pharmacology is often markedly toxic and must be precisely dosed in order to reach the therapeutic bioavailability under strict control. Transport properties are important tools in the process of interpretation and fine-tuning pharmaceutical applications, notably for drugs that have a long record of use and have met their limits of bioavailability. 5–Fluorouracil (5-FU) is one of the most used antineoplastic agents since its discovery in 1957. In this paper, binary mutual diffusion coefficients of 5-fluorouracil, obtained from a Taylor dispersion method setup are reported for aqueous solutions up to 75 mmol.kg−1. These data were complemented by viscosity measurements. The overall information allows to compute... (More)

Cancer pharmacology is often markedly toxic and must be precisely dosed in order to reach the therapeutic bioavailability under strict control. Transport properties are important tools in the process of interpretation and fine-tuning pharmaceutical applications, notably for drugs that have a long record of use and have met their limits of bioavailability. 5–Fluorouracil (5-FU) is one of the most used antineoplastic agents since its discovery in 1957. In this paper, binary mutual diffusion coefficients of 5-fluorouracil, obtained from a Taylor dispersion method setup are reported for aqueous solutions up to 75 mmol.kg−1. These data were complemented by viscosity measurements. The overall information allows to compute descriptive parameters and further interpretation on the basis of well-established models.

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author
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publishing date
type
Contribution to journal
publication status
published
keywords
5-Fluorouracil, Aqueous solutions, Binary mutual diffusion, Oncologic drugs transport properties
in
Journal of Chemical Thermodynamics
volume
161
article number
106533
publisher
Academic Press
external identifiers
  • scopus:85106583028
ISSN
0021-9614
DOI
10.1016/j.jct.2021.106533
language
English
LU publication?
no
additional info
Publisher Copyright: © 2021 Elsevier Ltd
id
6e8145b8-8388-47c6-9cac-e47ce1cdf308
date added to LUP
2024-07-22 10:54:22
date last changed
2024-08-15 10:11:49
@article{6e8145b8-8388-47c6-9cac-e47ce1cdf308,
  abstract     = {{<p>Cancer pharmacology is often markedly toxic and must be precisely dosed in order to reach the therapeutic bioavailability under strict control. Transport properties are important tools in the process of interpretation and fine-tuning pharmaceutical applications, notably for drugs that have a long record of use and have met their limits of bioavailability. 5–Fluorouracil (5-FU) is one of the most used antineoplastic agents since its discovery in 1957. In this paper, binary mutual diffusion coefficients of 5-fluorouracil, obtained from a Taylor dispersion method setup are reported for aqueous solutions up to 75 mmol.kg<sup>−1</sup>. These data were complemented by viscosity measurements. The overall information allows to compute descriptive parameters and further interpretation on the basis of well-established models.</p>}},
  author       = {{Verissimo, Luis M.P. and Cabral, Inês and Cabral, Ana M.T.D.P.V. and Utzeri, Gianluca and Veiga, Francisco J.B. and Valente, Artur J.M. and Ribeiro, Ana C.F.}},
  issn         = {{0021-9614}},
  keywords     = {{5-Fluorouracil; Aqueous solutions; Binary mutual diffusion; Oncologic drugs transport properties}},
  language     = {{eng}},
  publisher    = {{Academic Press}},
  series       = {{Journal of Chemical Thermodynamics}},
  title        = {{Transport properties of aqueous solutions of the oncologic drug 5-fluorouracil : A fundamental complement to therapeutics}},
  url          = {{http://dx.doi.org/10.1016/j.jct.2021.106533}},
  doi          = {{10.1016/j.jct.2021.106533}},
  volume       = {{161}},
  year         = {{2021}},
}