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Assessment of lifestyle factors helps to identify liver fibrosis due to non-alcoholic fatty liver disease in obesity

Lahelma, Mari ; Luukkonen, Panu K. ; Qadri, Sami ; Ahlholm, Noora ; Lallukka-Brück, Susanna ; Porthan, Kimmo ; Juuti, Anne ; Sammalkorpi, Henna ; Penttilä, Anne K. and Arola, Johanna , et al. (2021) In Nutrients 13(1).
Abstract

Only some individuals with obesity develop liver fibrosis due to non-alcoholic fatty liver disease (NAFLD-fibrosis). We determined whether detailed assessment of lifestyle factors in addition to physical, biochemical and genetic factors helps in identification of these patients. A total of 100 patients with obesity (mean BMI 40.0 ± 0.6 kg/m2 ) referred for bariatric surgery at the Helsinki University Hospital underwent a liver biopsy to evaluate liver histology. Physical activity was determined by accelerometer recordings and by the Modifiable Activity Questionnaire, diet by the FINRISK Food Frequency Questionnaire, and other lifestyle factors, such as sleep patterns and smoking, by face-to-face interviews. Physical and... (More)

Only some individuals with obesity develop liver fibrosis due to non-alcoholic fatty liver disease (NAFLD-fibrosis). We determined whether detailed assessment of lifestyle factors in addition to physical, biochemical and genetic factors helps in identification of these patients. A total of 100 patients with obesity (mean BMI 40.0 ± 0.6 kg/m2 ) referred for bariatric surgery at the Helsinki University Hospital underwent a liver biopsy to evaluate liver histology. Physical activity was determined by accelerometer recordings and by the Modifiable Activity Questionnaire, diet by the FINRISK Food Frequency Questionnaire, and other lifestyle factors, such as sleep patterns and smoking, by face-to-face interviews. Physical and biochemical parameters and genetic risk score (GRS based on variants in PNPLA3, TM6SF2, MBOAT7 and HSD17B13) were measured. Of all participants 49% had NAFLD-fibrosis. Independent predictors of NAFLD-fibrosis were low moderate-to-vigorous physical activity, high red meat intake, low carbohydrate intake, smoking, HbA1c, triglycerides and GRS. A model including these factors (areas under the receiver operating characteristics curve (AUROC) 0.90 (95% CI 0.84–0.96)) identified NAFLD-fibrosis significantly more accurately than a model including all but lifestyle factors (AUROC 0.82 (95% CI 0.73–0.91)) or models including lifestyle, physical and biochemical, or genetic factors alone. Assessment of lifestyle parameters in addition to physical, biochemical and genetic factors helps to identify obese patients with NAFLD-fibrosis.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diet, Glucose, Insulin, Physical activity, Stress
in
Nutrients
volume
13
issue
1
article number
169
pages
13 pages
publisher
MDPI AG
external identifiers
  • scopus:85099054940
  • pmid:33429859
ISSN
2072-6643
DOI
10.3390/nu13010169
language
English
LU publication?
yes
id
6ea09214-dd4b-44d9-8016-b61b2321ec06
date added to LUP
2021-01-20 08:15:11
date last changed
2024-04-18 00:38:16
@article{6ea09214-dd4b-44d9-8016-b61b2321ec06,
  abstract     = {{<p>Only some individuals with obesity develop liver fibrosis due to non-alcoholic fatty liver disease (NAFLD-fibrosis). We determined whether detailed assessment of lifestyle factors in addition to physical, biochemical and genetic factors helps in identification of these patients. A total of 100 patients with obesity (mean BMI 40.0 ± 0.6 kg/m<sup>2</sup> ) referred for bariatric surgery at the Helsinki University Hospital underwent a liver biopsy to evaluate liver histology. Physical activity was determined by accelerometer recordings and by the Modifiable Activity Questionnaire, diet by the FINRISK Food Frequency Questionnaire, and other lifestyle factors, such as sleep patterns and smoking, by face-to-face interviews. Physical and biochemical parameters and genetic risk score (GRS based on variants in PNPLA3, TM6SF2, MBOAT7 and HSD17B13) were measured. Of all participants 49% had NAFLD-fibrosis. Independent predictors of NAFLD-fibrosis were low moderate-to-vigorous physical activity, high red meat intake, low carbohydrate intake, smoking, HbA<sub>1c</sub>, triglycerides and GRS. A model including these factors (areas under the receiver operating characteristics curve (AUROC) 0.90 (95% CI 0.84–0.96)) identified NAFLD-fibrosis significantly more accurately than a model including all but lifestyle factors (AUROC 0.82 (95% CI 0.73–0.91)) or models including lifestyle, physical and biochemical, or genetic factors alone. Assessment of lifestyle parameters in addition to physical, biochemical and genetic factors helps to identify obese patients with NAFLD-fibrosis.</p>}},
  author       = {{Lahelma, Mari and Luukkonen, Panu K. and Qadri, Sami and Ahlholm, Noora and Lallukka-Brück, Susanna and Porthan, Kimmo and Juuti, Anne and Sammalkorpi, Henna and Penttilä, Anne K. and Arola, Johanna and Orho-Melander, Marju and Yki-Järvinen, Hannele}},
  issn         = {{2072-6643}},
  keywords     = {{Diet; Glucose; Insulin; Physical activity; Stress}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{Assessment of lifestyle factors helps to identify liver fibrosis due to non-alcoholic fatty liver disease in obesity}},
  url          = {{http://dx.doi.org/10.3390/nu13010169}},
  doi          = {{10.3390/nu13010169}},
  volume       = {{13}},
  year         = {{2021}},
}